KCNIP1

Last updated
KCNIP1
Protein KCNIP1 PDB 1s1e.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KCNIP1 , KCHIP1, VABP, potassium voltage-gated channel interacting protein 1
External IDs OMIM: 604660; MGI: 1917607; HomoloGene: 22824; GeneCards: KCNIP1; OMA:KCNIP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

30820

70357

Ensembl

ENSG00000182132

ENSMUSG00000053519

UniProt

Q9NZI2

Q9JJ57

RefSeq (mRNA)

NM_001034837
NM_001034838
NM_001278339
NM_001278340
NM_014592

Contents

NM_001190885
NM_001190886
NM_001290690
NM_027398
NM_001363115

RefSeq (protein)

NP_001030009
NP_001030010
NP_001265268
NP_001265269
NP_055407

NP_001177814
NP_001177815
NP_001277619
NP_081674
NP_001350044

Location (UCSC) Chr 5: 170.35 – 170.74 Mb Chr 11: 33.58 – 33.94 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene. [5] [6]

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily. [7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms. [6]

See also

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182132 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053519 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–556. Bibcode:2000Natur.403..553A. doi:10.1038/35000592. PMID   10676964. S2CID   4419472.
  6. 1 2 "Entrez Gene: KCNIP1 Kv channel interacting protein 1".
  7. ↑ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC   1887812 . PMID   17311005.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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