CLIC6

Last updated
CLIC6
Identifiers
Aliases CLIC6 , CLIC1L, chloride intracellular channel 6
External IDs OMIM: 615321; MGI: 2146607; HomoloGene: 43154; GeneCards: CLIC6; OMA:CLIC6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_053277
NM_001317009

NM_172469

RefSeq (protein)

NP_001303938
NP_444507

NP_766057

Location (UCSC) Chr 21: 34.67 – 34.72 Mb Chr 16: 92.28 – 92.34 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene. [5] [6]

Contents

The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [6]

Interactions

CLIC6 has been shown to interact with Dopamine receptor D3. [7]

Function

CLIC6 has been shown to form chloride selective redox and pH regulated ion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells. [8]

See also

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000159212 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022949 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, et al. (May 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–319. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
  6. 1 2 "Entrez Gene: CLIC6 chloride intracellular channel 6".
  7. Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID   14499480.
  8. Loyo-Celis V, Patel D, Sanghvi S, Kaur K, Ponnalagu D, Zheng Y, et al. (November 2023). "Biophysical characterization of chloride intracellular channel 6 (CLIC6)". The Journal of Biological Chemistry. 299 (11): 105349. doi: 10.1016/j.jbc.2023.105349 . PMC   10641671 . PMID   37838179.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.