AZD-5423

Last updated
AZD-5423
AZD5423 structure.svg
Identifiers
  • 2,2,2-Trifluoro-N-[(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(3-methoxyphenyl)-2-propanyl]acetamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard 100.205.965 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C25H21F4N3O3
Molar mass 487.455 g·mol−1
3D model (JSmol)
  • C[C@@H]([C@@H](c1cccc(c1)OC)Oc2ccc3c(c2)cnn3c4ccc(cc4)F)NC(=O)C(F)(F)F
  • InChI=1S/C25H21F4N3O3/c1-15(31-24(33)25(27,28)29)23(16-4-3-5-20(12-16)34-2)35-21-10-11-22-17(13-21)14-30-32(22)19-8-6-18(26)7-9-19/h3-15,23H,1-2H3,(H,31,33)/t15-,23-/m0/s1
  • Key:FCNQMDSJHADDFT-WNSKOXEYSA-N

AZD-5423 is a nonsteroidal glucocorticoid and phase II experimental drug being developed by AstraZeneca [1] and disclosed at the spring 2013 American Chemical Society meeting in New Orleans to treat respiratory diseases and in particular chronic obstructive pulmonary disease. [2] [3] [4] [5] [6]

Contents

It has completed a phase II clinical trial. [7]

See also

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References

  1. Hemmerling M, Nilsson S, Edman K, Eirefelt S, Russell W, Hendrickx R, et al. (October 2017). "Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases". Journal of Medicinal Chemistry. 60 (20): 8591–8605. doi:10.1021/acs.jmedchem.7b01215. PMID   28937774.
  2. "AZD 5423 - AdisInsight".
  3. Drahl C (2013). "Liveblogging First-Time Disclosures of Drug Structures from #ACSNOLA".
  4. GB2010051905 Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
  5. SE2009050900 A combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist
  6. SE2009000264 Combination of (a) glucocorticoid receptor modulator and (b) a β2-agonist
  7. Clinical trial number NCT01555099 for "Multi-centre Study to Assess the Efficacy and Safety of AZD5423 in COPD Patients on a Background Therapy of Formoterol" at ClinicalTrials.gov