Fludroxycortide

Last updated
Fludroxycortide
Fludroxycortide.svg
Clinical data
Trade names Cordran, Haelan
Other names6α-Fluoro-16α-hydroxyhydrocortisone 16,17-acetonide; 6α-Fluoro-11β,16α,17α,21-tetrahydroxypregn-4-ene-3,20-dione 16,17-acetonide
AHFS/Drugs.com Micromedex Detailed Consumer Information
Routes of
administration
Topical
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
Identifiers
  • 6-Fluoro-11,21-dihydroxy-16,17-[(l-methylethylidene)bis(oxy)]-(6α,11β,16α)-pregn-4-ene-3,20-dione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.014.724 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C24H33FO6
Molar mass 436.520 g·mol−1
3D model (JSmol)
  • O=C1\C=C5/[C@](C)(CC1)[C@@H]2[C@H]([C@H]3[C@](C[C@@H]2O)([C@@]4(OC(O[C@@H]4C3)(C)C)C(=O)CO)C)C[C@@H]5F
  • InChI=1S/C24H33FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h7,13-14,16-17,19-20,26,28H,5-6,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1 Yes check.svgY
  • Key:POPFMWWJOGLOIF-XWCQMRHXSA-N Yes check.svgY
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Fludroxycortide (INN, BAN, JAN), also known as flurandrenolide (USAN) and flurandrenolone, [1] is a synthetic topical corticosteroid and is used as an anti-inflammatory treatment for use on skin irritations. Trade names include Haelan (Typharm, UK) and Cordran (by Watson Pharmaceuticals, US). [2] [3]

Fludroxycortide is available in ointment, cream and as an impregnated tape (Haelan tape, Cordran tape). Licensed indications in the United Kingdom include recalcitrant dermatoses. [4] [5]

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References

  1. CID 15209 from PubChem
  2. "Fludroxycortide". Drugs.com. Archived from the original on 2019-08-29. Retrieved 2018-01-23.
  3. "Fludroxycortide". Patient.info. 30 August 2022.
  4. Haelan Tape Summary of Product Characteristics [ permanent dead link ]
  5. Nakamura H, Motoyoshi S, Ishii K, Seto Y, Shimizu M (October 1980). "[Anti-inflammatory activity of a topical glucocorticoid, fludroxycortide tape in experimental animals (author's transl)]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 76 (7): 595–607. doi: 10.1254/fpj.76.595 . PMID   7215997.