테닐록사진

Teniloxazine
테닐록사진
Teniloxazine.svg
임상 데이터
기타 이름Y-8894
루트
행정부.		오랄
ATC 코드
  • 없음.
법적 상태
법적 상태
  • 일반 : ( (처방만)
식별자
  • 2-{[2-(티오펜-2-일메틸)아크록시]메틸}아크롬린
CAS 번호
PubChem CID
켐스파이더
유니
화학 및 물리 데이터
공식C16H19NO2S
몰 질량289.39 g/g−1/g/g
3D 모델(JSmol)
  • O1CCNCC1COC2cc2Cc3
  • InChI=1S/C16H19NO2S/c1-2-6-16(19-12-14-17-7-8-14)13(4-1)10-15-5-3-9-20-15/h1-6,9,14,17H,7-8,10-12H2 checkY
  • 키 : OILWWIVKIDXCIB-UHFFFAOYSA-N checkY
☒NcheckY (이게 뭐죠?) (표준)

텐옥사진(루셀란, 메타톤)은 수폭사진, 술폭사진으로도 알려져 [1]있다.1980년대 [2][3][4][5][6][7][8][9]뇌혈관 부전증 치료를 위한 신경보호 및 이방성 물질로 연구되었으나,[10] 결국 항우울제로 개발되어 승인되었다.이는 세로토닌 및 도파민 전달체보다 공정한 선택성과 함께 강력한 노르에피네프린 재흡수 억제제 역할을 하며, 5-HT2A [7][10][11]수용체의 길항제 역할도 한다.

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레퍼런스

  1. ^ Ganellin CR, Triggle DJ, Macdonald F (1997). Dictionary of pharmacological agents. CRC Press. p. 1905. ISBN 978-0-412-46630-4. Retrieved 27 October 2011.
  2. ^ Anami K, Yamamoto Y, Setoguchi M (February 1985). "[Pharmacological studies on sufoxazine (Y-8894). (I) Effects on experimental amnesia in mice]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 85 (2): 71–7. doi:10.1254/fpj.85.71. PMID 2859238.
  3. ^ Izumi N, Yasuda H (October 1985). "[Pharmacological studies on sufoxazine (Y-8894). (II). Anti-anoxic effect]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 86 (4): 323–8. doi:10.1254/fpj.86.323. PMID 4085932.
  4. ^ Usa T, Morimoto Y, Fukuda T, Anami K, Setoguchi M, Maruyama Y (October 1986). "[Pharmacological studies on Y-8894. (III). Its effect on the abnormal electrocorticogram induced by destruction of the internal capsule]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 88 (4): 289–97. doi:10.1254/fpj.88.289. PMID 3491778.
  5. ^ Yasuda H, Izumi N, Nakanishi M, Anami K, Maruyama Y (November 1986). "[Pharmacological studies on Y-8894. (IV). Ameliorative effect on a cerebral energy metabolism disorder induced by KCN]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 88 (5): 363–7. doi:10.1254/fpj.88.363. PMID 3817653.
  6. ^ Anami K, Yamamoto Y, Setoguchi M, Maruyama Y (March 1987). "[Pharmacological studies on Y-8894. (V) Effect on learning and memory in intact and experimentally amnesic rats]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 89 (3): 145–53. doi:10.1254/fpj.89.145. PMID 2884174.
  7. ^ a b Setoguchi M, Takehara S, Sakamori M, Anami K, Maruyama Y (July 1987). "[Pharmacological studies on Y-8894 (VI). The effect on monoamine uptake and turnover in mouse brain]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 90 (1): 41–9. doi:10.1254/fpj.90.41. PMID 2443434.
  8. ^ Yasumatsu H, Yamamoto Y, Takamuku H, et al. (December 1987). "[Pharmacological studies on Y-8894. (VII). Effects on transient cerebral ischemia-induced amnesia in rats]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 90 (6): 321–30. doi:10.1254/fpj.90.321. PMID 3443414.
  9. ^ Anami K, Setoguchi M, Senoh H (August 1988). "[Pharmacological studies on Y-8894. (VIII). Effects on learning and memory in the radial maze task in mice]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 92 (2): 113–8. doi:10.1254/fpj.92.113. PMID 3224898.
  10. ^ a b Ogura C, Kishimoto A, Kunimoto N, et al. (May 1987). "Clinical pharmacology of a new antidepressant, Y-8894 in healthy young and elderly volunteers". British Journal of Clinical Pharmacology. 23 (5): 537–43. doi:10.1111/j.1365-2125.1987.tb03089.x. PMC 1386189. PMID 3593624.
  11. ^ "Therapeutic Agent for Attention-Deficit Hyperactivity Disorder - Google Patents". Retrieved October 27, 2011.