데스메틸시부트라민

Desmethylsibutramine
데스메틸시부트라민
Desmethylsibutramine structure.png
식별자
  • 1-[1-(4-클로로페닐)시클로부틸]-N, 3-디메틸부탄-1-아민
CAS 번호
PubChem CID
화학 및 물리 데이터
공식C16H24클론N
몰 질량265.83 g/g−1/g/g
3D 모델(JSmol)
  • CC(C)CC(C1(CC1)C2=CC=C(C=C2)Cl)엔씨
  • InChI=1S/C16H24ClN/c1-12(2)11-15(18-3)16(9-4-10-16)13-5-7-14(17)8-6-13/h5-8,12,15,18H,4,9-11H2,1-3H3
  • 키: PLXKZLXYHLWHR-UHFFFAOYSA-N

데스메틸시부트라민(BTS-54354)은 식욕 억제제 시부트라민의 활성 대사물이다.시부트라민보다 더 강력한 모노아민 재흡수 억제제이며, N-에틸 및 3,4-디클로로 [1][2][3][4][5]유도체와 같은 관련 화합물과 함께 식이 보조 식품으로 판매되는 체중 감량 제품의 성분으로 판매되고 있다.

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레퍼런스

  1. ^ Glick SD, Haskew RE, Maisonneuve IM, Carlson JN, Jerussi TP (May 2000). "Enantioselective behavioral effects of sibutramine metabolites". European Journal of Pharmacology. 397 (1): 93–102. doi:10.1016/s0014-2999(00)00216-8. PMID 10844103.
  2. ^ Park SR, Lee JG, Roh SH, Kim G, Kwon CH, Park HR, et al. "Determination of PDE-5 inhibitors and appetite suppressants in adulterated dietary supplements using LC/PDA and LC/MS". Food Additives & Contaminants. Part B, Surveillance. 5 (1): 29–32. doi:10.1080/19393210.2012.656706. PMID 24779692.
  3. ^ Reeuwijk NM, Venhuis BJ, de Kaste D, Hoogenboom RL, Rietjens IM, Martena MJ. "Active pharmaceutical ingredients detected in herbal food supplements for weight loss sampled on the Dutch market". Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment. 31 (11): 1783–1793. doi:10.1080/19440049.2014.958574. PMID 25247833.
  4. ^ Zeng Y, Xu Y, Kee CL, Low MY, Ge X (2016). "Analysis of 40 weight loss compounds adulterated in health supplements by liquid chromatography quadrupole linear ion trap mass spectrometry". Drug Testing and Analysis. 8 (3–4): 351–6. doi:10.1002/dta.1846. PMID 26305055.
  5. ^ Jeong D, Choe S, Lee S, Kim KM, Pyo J (January 2021). "Metabolic analysis of the illegal analogues of anti-obesity drugs using LC-Q-TOF-MS/MS". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1163: 122502. doi:10.1016/j.jchromb.2020.122502. PMID 33412503.
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