5-요도와일라르디아인

5-Iodowillardiine
5-요도와일라르디아인
5-Iodowillardiine.png
이름
IUPAC 이름
(2S)-2-아미노-3-(5-iodo-2,4-dioxopyrimidin-1-yl)프로파노산
식별자
3D 모델(JSmol)
켐벨
켐스파이더
드러그뱅크
펍켐 CID
  • InChi=1S/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/H1,4H,2,9H2,(H,13,14)/t4-/m0s1 checkY
    키: AXXYLTBQQBTES-BYPYZUCNSA-N checkY
  • InChi=1/C7H8IN3O4/c8-3-1-11(2-4(13)6(13)14)7(15)10-5(15)12/H1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
    키: AXXYLTBQQBT-BYPYZUCNBL
  • C1=C(=O)NC(=O)N1C[C@@H](C(=O)O)N)i
  • O=C(O)[C@@H](N)CN1/C=C(/I)C(=O)NC1=O
특성.
C7H8IN3O4
어금질량 325.061 g/197
달리 명시된 경우를 제외하고, 표준 상태(25°C [77°F], 100 kPa)의 재료에 대한 데이터가 제공된다.
☒ NVERIFI (?란checkY☒N?
Infobox 참조 자료

5-오디오윌라르디인은 카이네이트 수용체에 대한 선택적 작용제로, AMPA 수용체에는 제한적인 효과만 있을 뿐이다.[1] GluR5 서브유닛으로 구성된 카이네이트 수용체에 선택적이다.[2][3] 체내 흥분성 신경독소체지만 뇌와 척수에 있는 다양한 카이네이트 수용체의 아형과 기능을 특징짓는 데 매우 유용하다는 것이 입증되었다.[4][5][6][7][8]

참조

  1. ^ Patneau, DK; Mayer, ML; Jane, DE; Watkins, JC (1992). "Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine". Journal of Neuroscience. 12 (2): 595–606. doi:10.1523/jneurosci.12-02-00595.1992. PMC 6575614. PMID 1371315.
  2. ^ Swanson, GT; Green, T; Heinemann, SF (1998). "Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine". Molecular Pharmacology. 53 (5): 942–9. PMID 9584222.
  3. ^ Cui, C; Mayer, ML (1999). "Heteromeric kainate receptors formed by the coassembly of GluR5, GluR6, and GluR7". Journal of Neuroscience. 19 (19): 8281–91. doi:10.1523/JNEUROSCI.19-19-08281.1999. PMC 6782997. PMID 10493729.
  4. ^ Moldrich, RX; Cheung, NS; Pascoe, CJ; Beart, PM (1999). "Excitotoxic injury profiles of low-affinity kainate receptor agonists in cortical neuronal cultures". European Journal of Pharmacology. 378 (2): R1–3. doi:10.1016/S0014-2999(99)00456-2. PMID 10478637.
  5. ^ Moldrich, RX; Beart, PM; Pascoe, CJ; Cheung, NS (2000). "Low-affinity kainate receptor agonists induce insult-dependent apoptosis and necrosis in cultured murine cortical neurons". Journal of Neuroscience Research. 59 (6): 788–96. doi:10.1002/(SICI)1097-4547(20000315)59:6<788::AID-JNR11>3.0.CO;2-K. PMID 10700016.
  6. ^ Mascias, P; Scheede, M; Bloms-Funke, P; Chizh, B (2002). "Modulation of spinal nociception by GluR5 kainate receptor ligands in acute and hyperalgesic states and the role of gabaergic mechanisms". Neuropharmacology. 43 (3): 327–39. doi:10.1016/S0028-3908(02)00112-0. PMID 12243762. S2CID 29126134.
  7. ^ Alt, A; Weiss, B; Ogden, AM; Knauss, JL; Oler, J; Ho, K; Large, TH; Bleakman, D (2004). "Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro". Neuropharmacology. 46 (6): 793–806. doi:10.1016/j.neuropharm.2003.11.026. PMID 15033339. S2CID 23514969.
  8. ^ Jane, DE; Lodge, D; Collingridge, GL (2009). "Kainate receptors: pharmacology, function and therapeutic potential". Neuropharmacology. 56 (1): 90–113. doi:10.1016/j.neuropharm.2008.08.023. PMID 18793656. S2CID 25291377.