UGT2B17

UGT2B17
Identifiers
Aliases	UGT2B17 , BMND12, UDPGT2B17, UDP glucuronosyltransferase family 2 member B17
External IDs	OMIM: 601903 MGI: 1919023 HomoloGene: 68144 GeneCards: UGT2B17
Gene location (Human)
Chr.	Chromosome 4 (human)
End	68,576,413 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	86,926,530 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity, transferring glycosyl groups ; • transferase activity ; • glucuronosyltransferase activity ; • retinoic acid binding ; • transferase activity, transferring hexosyl groups ; • UDP-glycosyltransferase activity ;
Cellular component	• integral component of membrane ; • organelle membrane ; • endoplasmic reticulum membrane ; • membrane ; • intracellular membrane-bounded organelle ; • endoplasmic reticulum ;
Biological process	• steroid metabolic process ; • metabolism ; • cellular glucuronidation ;
	Sources:Amigo / QuickGO
Orthologs
	7367
	71773
	ENSG00000197888
	ENSMUSG00000035836
	O75795
	Q8R084
	NM_001077
	NM_152811
	NP_001068
	NP_690024
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 02, 2021

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.^[5]^[6]

UGT2B17 belongs to the family of UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17), enzymes that catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones.[supplied by OMIM]^[6] It also metabolizes 3-hydroxycotinine, which is minor nicotine metabolite^[7]

Related Research Articles

Gilbert's syndrome (GS) is a mild liver disorder in which the liver does not properly process bilirubin. Many people never have symptoms. Occasionally a slight yellowish color of the skin or whites of the eyes may occur. Other possible symptoms include feeling tired, weakness, and abdominal pain.

Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. These linkages involve glycosidic bonds.

Uridine 5'-diphospho-glucuronosyltransferase is a microsomal glycosyltransferase that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule. This is a glucuronidation reaction.

UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene.

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain. In humans, UDP-Glucuronosyltransferase-2B7 is encoded by the UGT2B7 gene.

UDP-glucuronosyltransferase 1-6 is an enzyme that in humans is encoded by the UGT1A6 gene.

UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene.

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene.

UDP-glucuronosyltransferase 1-3 is an enzyme that in humans is encoded by the UGT1A3 gene.

UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.

UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an enzyme that in humans is encoded by the UGT2B4 gene.

UDP glucuronosyltransferase 1 family, polypeptide A cluster (UGT1A) is a human gene locus which includes several UDP glucuronosyltransferases.

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene. It is responsible for glucuronidation of nicotine and cotinine.

Hyodeoxycholic acid, also known as 3α,6α-Dihydroxy-5β-cholan-24-oic acid or HDCA, is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria. It differs from deoxycholic acid in that the 6α-hydroxyl is in the 12 position in the former. The 6α-hydroxyl group makes HDCA a hydrophilic acid, a property it shares with hyocholic acid. HDCA is present in mammalian species in different proportions. It is the main acid constituent of hog bile, and for this reason it was used industrially as precursor for steroid synthesis before total synthesis became practical.

UDP-glucuronosyltransferase 1-5 is an enzyme that in humans is encoded by the UGT1A5 gene.

UDP-glucuronosyltransferase 1-9 is an enzyme that in humans is encoded by the UGT1A9 gene.

UDP-glucuronosyltransferase 1-8 is an enzyme that in humans is encoded by the UGT1A8 gene.

UDP glucuronosyltransferase 2 family, polypeptide B1, also known as UGT2B1, is an enzyme that in humans is encoded by the UGT2B1 gene.

'UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene.

UDP glucuronosyltransferase 1 family, polypeptide A7 is a protein that in humans is encoded by the UGT1A7 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197888 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035836 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Beaulieu M, Levesque E, Hum DW, Belanger A (Nov 1996). "Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids". J Biol Chem. 271 (37): 22855–62. doi: 10.1074/jbc.271.37.22855 . PMID 8798464.
1 2 "Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17".
↑ Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research . 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997 . PMID 20876810.

Chung LW, Coffey DS (1978). "Androgen glucuronide. II. Differences in its formation by human normal and benign hyperplastic prostates". Investigative Urology. 15 (5): 385–8. PMID 76619.
Moghissi E, Ablan F, Horton R (1984). "Origin of plasma androstanediol glucuronide in men". J. Clin. Endocrinol. Metab. 59 (3): 417–21. doi:10.1210/jcem-59-3-417. PMID 6746859.
Beaulieu M, Lévesque E, Tchernof A, et al. (1997). "Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme". DNA Cell Biol. 16 (10): 1143–54. doi:10.1089/dna.1997.16.1143. PMID 9364925.
Collier AC, Ganley NA, Tingle MD, et al. (2002). "UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term". Biochem. Pharmacol. 63 (3): 409–19. doi:10.1016/S0006-2952(01)00890-5. PMID 11853692.
Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium". Endocr. Res. 30 (4): 717–25. doi:10.1081/ERC-200044014. PMID 15666817. S2CID 10971899.
Lazarus P, Zheng Y, Aaron Runkle E, et al. (2006). "Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes". Pharmacogenet. Genomics. 15 (11): 769–78. doi:10.1097/01.fpc.0000175596.52443.ef. PMID 16220109. S2CID 10171438.
Jakobsson J, Ekström L, Inotsume N, et al. (2006). "Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism". J. Clin. Endocrinol. Metab. 91 (2): 687–93. doi: 10.1210/jc.2005-1643 . PMID 16332934.
Park J, Chen L, Ratnashinge L, et al. (2006). "Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men". Cancer Epidemiol. Biomarkers Prev. 15 (8): 1473–8. doi: 10.1158/1055-9965.EPI-06-0141 . PMID 16896035.
Gallagher CJ, Muscat JE, Hicks AN, et al. (2007). "The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer". Cancer Epidemiol. Biomarkers Prev. 16 (4): 823–8. doi: 10.1158/1055-9965.EPI-06-0823 . PMID 17416778.
Park JY, Tanner JP, Sellers TA, et al. (2007). "Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk". Urology. 70 (2): 374–9. doi:10.1016/j.urology.2007.03.001. PMID 17826523.
Chouinard S, Barbier O, Bélanger A (2008). "UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells". J. Biol. Chem. 282 (46): 33466–74. doi: 10.1074/jbc.M703370200 . PMID 17848572.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197888 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035836 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8798464-5] Beaulieu M, Levesque E, Hum DW, Belanger A (Nov 1996). "Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids". J Biol Chem. 271 (37): 22855–62. doi: 10.1074/jbc.271.37.22855 . PMID 8798464.

[entrez-6] 1 2 "Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17".

[pmid20876810-7] Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research . 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997 . PMID 20876810.

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UGT2B17

Related Research Articles

References

Further reading