UGT1A10

UGT1A10
Identifiers
Aliases	UGT1A10 , UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J, UDP glucuronosyltransferase family 1 member A10, UGT1-01, UGT-1A, hUG-BR1, UGT1, UGT1A, UGT1.1, GNT1, UGT1A1
External IDs	OMIM: 606435 MGI: 3576092 HomoloGene: 133281 GeneCards: UGT1A10
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,773,300 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,146,719 bp
RNA expression pattern
	Top expressed in
	duodenum; ; rectum; ; gallbladder; ; appendix; ; gastric mucosa; ; body of stomach; ; islet of Langerhans; ; urinary bladder; ; fundus; ; smooth muscle tissue;
	Top expressed in
	hepatobiliary system; ; liver; ; duodenum; ; colon; ; renal cortex; ; proximal tubule; ; stomach; ; kidney; ; ileum; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; retinoic acid binding ; hexosyltransferase activity ; protein homodimerization activity ; glycosyltransferase activity ; protein heterodimerization activity ; enzyme binding ; protein kinase C binding ; glucuronosyltransferase activity ; UDP-glycosyltransferase activity ;
Cellular component	integral component of membrane ; membrane ; intracellular membrane-bounded organelle ; endoplasmic reticulum ; endoplasmic reticulum membrane ;
Biological process	negative regulation of cellular glucuronidation ; xenobiotic glucuronidation ; flavone metabolic process ; metabolism ; negative regulation of glucuronosyltransferase activity ; negative regulation of fatty acid metabolic process ; cellular glucuronidation ; flavonoid glucuronidation ;
	Sources:Amigo / QuickGO
Orthologs
	54575
	394434
	ENSG00000242515
	ENSMUSG00000090175
	Q9HAW8
	Q62452
	NM_019075
	NM_201644
	NP_061948
	NP_964006
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene.^[5]^[6]^[7]

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Irinotecan Pathway edit]]

Irinotecan Pathway edit

↑ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359".

Related Research Articles

Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. These linkages involve glycosidic bonds.

<span class="mw-page-title-main">Glucuronosyltransferase</span> Class of enzymes

Uridine 5'-diphospho-glucuronosyltransferase is a microsomal glycosyltransferase that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule. This is a glucuronidation reaction.

UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene.

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain. In humans, UDP-Glucuronosyltransferase-2B7 is encoded by the UGT2B7 gene.

UDP-glucuronosyltransferase 1-6 is an enzyme that in humans is encoded by the UGT1A6 gene.

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene.

UDP-glucuronosyltransferase 1-3 is an enzyme that in humans is encoded by the UGT1A3 gene.

Dimethylaniline monooxygenase [N-oxide-forming] 1 is an enzyme that in humans is encoded by the FMO1 gene.

UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.

UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an enzyme that in humans is encoded by the UGT2B4 gene.

Dimethylaniline monooxygenase [N-oxide-forming] 5 is an enzyme that in humans is encoded by the FMO5 gene.

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.

UDP glucuronosyltransferase 1 family, polypeptide A cluster (UGT1A) is a human gene locus which includes several UDP glucuronosyltransferases.

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene. It is responsible for glucuronidation of nicotine and cotinine.

UDP-glucuronosyltransferase 1-5 is an enzyme that in humans is encoded by the UGT1A5 gene.

UDP-glucuronosyltransferase 1-9 is an enzyme that in humans is encoded by the UGT1A9 gene.

UDP-glucuronosyltransferase 1-8 is an enzyme that in humans is encoded by the UGT1A8 gene.

UDP glucuronosyltransferase 2 family, polypeptide B1, also known as UGT2B1, is an enzyme that in humans is encoded by the UGT2B1 gene.

UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene.

UDP glucuronosyltransferase 1 family, polypeptide A7 is a protein that in humans is encoded by the UGT1A7 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000242515 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (Oct 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.
↑ Mojarrabi B, Mackenzie PI (Oct 1997). "The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid". Biochem Biophys Res Commun. 238 (3): 775–8. doi:10.1006/bbrc.1997.7388. PMID 9325166.
1 2 "Entrez Gene: UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10".

Tukey RH, Strassburg CP (2000). "Human UDP-glucuronosyltransferases: metabolism, expression, and disease". Annu. Rev. Pharmacol. Toxicol. 40: 581–616. doi:10.1146/annurev.pharmtox.40.1.581. PMID 10836148.
Tukey RH, Strassburg CP (2001). "Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract". Mol. Pharmacol. 59 (3): 405–14. doi:10.1124/mol.59.3.405. PMID 11179432. S2CID 21500183.
King CD, Rios GR, Green MD, Tephly TR (2001). "UDP-glucuronosyltransferases". Curr. Drug Metab. 1 (2): 143–61. doi:10.2174/1389200003339171. PMID 11465080.
Harding D, Jeremiah SJ, Povey S, Burchell B (1990). "Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1". Ann. Hum. Genet. 54 (Pt 1): 17–21. doi:10.1111/j.1469-1809.1990.tb00356.x. PMID 2108603. S2CID 35661967.
van Es HH, Bout A, Liu J, et al. (1993). "Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37". Cytogenet. Cell Genet. 63 (2): 114–6. doi:10.1159/000133513. PMID 8467709.
Strassburg CP, Oldhafer K, Manns MP, Tukey RH (1997). "Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue". Mol. Pharmacol. 52 (2): 212–20. doi:10.1124/mol.52.2.212. PMID 9271343. S2CID 37098463.
Mojarrabi B, Mackenzie PI (1998). "Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon". Biochem. Biophys. Res. Commun. 247 (3): 704–9. doi:10.1006/bbrc.1998.8843. PMID 9647757.
Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus". Biochem. J. 338 (2): 489–98. doi:10.1042/0264-6021:3380489. PMC 1220077 . PMID 10024527.
Cheng Z, Radominska-Pandya A, Tephly TR (1999). "Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10". Drug Metab. Dispos. 27 (10): 1165–70. PMID 10497143.
Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". J. Biol. Chem. 275 (46): 36164–71. doi: 10.1074/jbc.M002180200 . PMID 10748067.
Gong QH, Cho JW, Huang T, et al. (2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics. 11 (4): 357–68. doi:10.1097/00008571-200106000-00011. PMID 11434514.
Zheng Z, Fang JL, Lazarus P (2002). "Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues". Drug Metab. Dispos. 30 (4): 397–403. doi:10.1124/dmd.30.4.397. PMID 11901093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Jinno H, Saeki M, Tanaka-Kagawa T, et al. (2003). "Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10". Drug Metab. Dispos. 31 (5): 528–32. doi:10.1124/dmd.31.5.528. PMID 12695339.

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[WikiPathways-8] The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359".

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000242515 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9295054-5] Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (Oct 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.

[pmid9325166-6] Mojarrabi B, Mackenzie PI (Oct 1997). "The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid". Biochem Biophys Res Commun. 238 (3): 775–8. doi:10.1006/bbrc.1997.7388. PMID 9325166.

[entrez-7] 1 2 "Entrez Gene: UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10".

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UGT1A10

Contents

Interactive pathway map

Related Research Articles

References

Further reading