UGT1A3

Last updated
UGT1A3
Identifiers
Aliases UGT1A3 , UDPGT, UDPGT 1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C, UGT1A3S, UDP glucuronosyltransferase family 1 member A3
External IDs OMIM: 606428 MGI: 3576049 HomoloGene: 86211 GeneCards: UGT1A3
Orthologs
SpeciesHumanMouse
Entrez

54659

22236

Ensembl

ENSG00000288702

ENSMUSG00000090171

UniProt

P35503

P70691

RefSeq (mRNA)

NM_019093

NM_013701

RefSeq (protein)

NP_061966

NP_038729

Location (UCSC) Chr 2: 233.73 – 233.77 Mb Chr 1: 88.13 – 88.15 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

UDP-glucuronosyltransferase 1-3 is an enzyme that in humans is encoded by the UGT1A3 gene. [5] [6] [7]

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo(a)pyrene. [8] [9] [10]

Related Research Articles

<span class="mw-page-title-main">Gilbert's syndrome</span> Medical condition

Gilbert syndrome (GS) is a syndrome in which the liver of affected individuals processes bilirubin more slowly than the majority. Many people never have symptoms. Occasionally jaundice may occur.

Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. These linkages involve glycosidic bonds.

<span class="mw-page-title-main">Glucuronic acid</span> Chemical compound

Glucuronic acid is a uronic acid that was first isolated from urine. It is found in many gums such as gum arabic, xanthan, and kombucha tea and is important for the metabolism of microorganisms, plants and animals.

<span class="mw-page-title-main">Glucuronosyltransferase</span> Class of enzymes

Uridine 5'-diphospho-glucuronosyltransferase is a microsomal glycosyltransferase that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule. This is a glucuronidation reaction.

<span class="mw-page-title-main">UDP glucuronosyltransferase 1 family, polypeptide A1</span> Protein-coding gene in the species Homo sapiens

UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene.

<span class="mw-page-title-main">UGT2B7</span> Protein-coding gene in the species Homo sapiens

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain. In humans, UDP-Glucuronosyltransferase-2B7 is encoded by the UGT2B7 gene.

<span class="mw-page-title-main">UGT1A6</span> Protein-coding gene in the species Homo sapiens

UDP-glucuronosyltransferase 1-6 is an enzyme that in humans is encoded by the UGT1A6 gene.

<span class="mw-page-title-main">UGT1A10</span> Protein-coding gene in the species Homo sapiens

UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene.

<span class="mw-page-title-main">UGT2B15</span> Protein-coding gene in the species Homo sapiens

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene.

<span class="mw-page-title-main">UGT1A4</span> Enzyme and protein-coding gene in humans

UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.

<span class="mw-page-title-main">UGT2B4</span> Protein-coding gene in the species Homo sapiens

UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an enzyme that in humans is encoded by the UGT2B4 gene.

<span class="mw-page-title-main">UGT2B17</span> Protein-coding gene in the species Homo sapiens

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.

UDP glucuronosyltransferase 1 family, polypeptide A cluster (UGT1A) is a human gene locus which includes several UDP glucuronosyltransferases.

<span class="mw-page-title-main">UGT2B10</span> Protein-coding gene in the species Homo sapiens

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene. It is responsible for glucuronidation of nicotine and cotinine.

<span class="mw-page-title-main">UGT1A5</span> Protein-coding gene in the species Homo sapiens

UDP-glucuronosyltransferase 1-5 is an enzyme that in humans is encoded by the UGT1A5 gene.

<span class="mw-page-title-main">UGT1A9</span> Protein-coding gene in the species Homo sapiens

UDP-glucuronosyltransferase 1-9 is an enzyme that in humans is encoded by the UGT1A9 gene.

<span class="mw-page-title-main">UGT1A8</span> Protein-coding gene in the species Homo sapiens

UDP-glucuronosyltransferase 1-8 is an enzyme that in humans is encoded by the UGT1A8 gene.

<span class="mw-page-title-main">UGT2A1</span> Protein-coding gene in the species Homo sapiens

UDP glucuronosyltransferase 2 family, polypeptide B1, also known as UGT2B1, is an enzyme that in humans is encoded by the UGT2B1 gene.

<span class="mw-page-title-main">UGT2A2</span> Protein-coding gene in the species Homo sapiens

UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene.

<i>UGT1A7</i> (gene) Protein-coding gene in the species Homo sapiens

UDP glucuronosyltransferase 1 family, polypeptide A7 is a protein that in humans is encoded by the UGT1A7 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000288702 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090171 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Gene: UGT1A3 (ENSG00000243135) - Summary - Homo sapiens - Ensembl genome browser 89". may2017.archive.ensembl.org. Retrieved 2019-05-18.
  6. ↑ "Gene: Ugt1a2 (ENSMUSG00000090171) - Summary - Mus musculus - Ensembl genome browser 89". may2017.archive.ensembl.org. Retrieved 2019-05-18.
  7. ↑ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, et al. (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID   9295054.
  8. ↑ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (February 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". The Journal of Biological Chemistry. 267 (5): 3257–61. doi: 10.1016/S0021-9258(19)50724-4 . PMID   1339448.
  9. ↑ Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, Kubota S, Carvalho S, Pennington MW, Owens IS, Popescu NC (June 2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics. 11 (4): 357–68. doi:10.1097/00008571-200106000-00011. PMID   11434514.
  10. ↑ "UGT1A3 UDP glucuronosyltransferase family 1 member A3 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-05-18.

Further reading

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