FUT9

FUT9
Identifiers
Aliases	FUT9 , Fuc-TIX, fucosyltransferase 9
External IDs	OMIM: 606865 MGI: 1330859 HomoloGene: 4800 GeneCards: FUT9
Gene location (Human)
Chr.	Chromosome 6 (human)
End	96,215,612 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	25,800,244 bp
RNA expression pattern
	Top expressed in
	pylorus; ; cerebellar vermis; ; Brodmann area 46; ; endothelial cell; ; orbitofrontal cortex; ; postcentral gyrus; ; Brodmann area 23; ; middle temporal gyrus; ; entorhinal cortex; ; Region I of hippocampus proper;
	Top expressed in
	cerebellar vermis; ; lateral geniculate nucleus; ; medial geniculate nucleus; ; dorsal tegmental nucleus; ; medial dorsal nucleus; ; lateral hypothalamus; ; medial vestibular nucleus; ; globus pallidus; ; ventral tegmental area; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity ; alpha-(1->3)-fucosyltransferase activity ; fucosyltransferase activity ; transferase activity ;
Cellular component	integral component of membrane ; Golgi apparatus ; Golgi cisterna membrane ; membrane ; Golgi membrane ;
Biological process	L-fucose catabolic process ; fucosylation ; nervous system development ; protein glycosylation ; carbohydrate metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	10690
	14348
	ENSG00000172461
	ENSMUSG00000055373
	Q9Y231
	O88819
	NM_006581
	NM_010243
	NP_006572
	NP_034373
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 16, 2023

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT9 gene.^[5]^[6]^[7]

FUT9 is one of several alpha-3-fucosyltransferases that can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides. FUT9 synthesizes the LeX oligosaccharide (CD15), which is expressed in organ buds progressing in mesenchyma during human embryogenesis.[supplied by OMIM]^[7]

Related Research Articles

A fucosyltransferase is an enzyme that transfers an L-fucose sugar from a GDP-fucose donor substrate to an acceptor substrate. The acceptor substrate can be another sugar such as the transfer of a fucose to a core GlcNAc (N-acetylglucosamine) sugar as in the case of N-linked glycosylation, or to a protein, as in the case of O-linked glycosylation produced by O-fucosyltransferase. There are various fucosyltransferases in mammals, the vast majority of which, are located in the Golgi apparatus. The O-fucosyltransferases have recently been shown to localize to the endoplasmic reticulum (ER).

Galactoside 3(4)-L-fucosyltransferase is an enzyme that in humans is encoded by the FUT3 gene.

Beta-1,4-galactosyltransferase 1 is an enzyme that in humans is encoded by the B4GALT1 gene.

Glucosidase 2 subunit beta is an enzyme that in humans is encoded by the PRKCSH gene.

Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene. It affects the secretor status of ABO antigens.

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene.

Mucin-7 is a protein that in humans is encoded by the MUC7 gene. In animals, the MUC7 gene is found in most placental mammals, but not marsupials.

Galactoside 2-alpha-L-fucosyltransferase 1 is an enzyme that in humans is encoded by the FUT1 gene.

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the GCNT1 gene.

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.

Polypeptide N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the GALNT1 gene.

Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.

Polypeptide N-acetylgalactosaminyltransferase 2 is an enzyme that in humans is encoded by the GALNT2 gene.

Polypeptide N-acetylgalactosaminyltransferase 13 is an enzyme that in humans is encoded by the GALNT13 gene.

Beta-1,3-glucosyltransferase is an enzyme that in humans is encoded by the B3GALTL gene.

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene. This enzyme adds a N-Acetylneuraminic acid to an O-linked N-Acetylgalactosamine (GalNAc) on a peptide/proteins with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers Thr over Ser containing GalNAc residues.

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT5 gene.

Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the CSGALNACT1 gene.

Fucosyltransferase 4 , also known as FUT4, is an enzyme which in humans is encoded by the FUT4 gene.

Fucosyltransferase 4 is a protein that in humans is encoded by the FUT4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172461 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055373 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kaneko M, Kudo T, Iwasaki H, Ikehara Y, Nishihara S, Nakagawa S, Sasaki K, Shiina T, Inoko H, Saitou N, Narimatsu H (Jul 1999). "Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX". FEBS Lett. 452 (3): 237–42. doi: 10.1016/S0014-5793(99)00640-7 . PMID 10386598. S2CID 21861521.
↑ Kaneko M, Kudo T, Iwasaki H, Shiina T, Inoko H, Kozaki T, Saitou N, Narimatsu H (Jan 2000). "Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization". Cytogenet Cell Genet. 86 (3–4): 329–30. doi:10.1159/000015329. PMID 10575236. S2CID 85080516.
1 2 "Entrez Gene: FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Nishihara S, Iwasaki H, Kaneko M, et al. (2000). "Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue". FEBS Lett. 462 (3): 289–94. doi: 10.1016/S0014-5793(99)01549-5 . PMID 10622713. S2CID 37842289.
Cailleau-Thomas A, Coullin P, Candelier JJ, et al. (2000). "FUT4 and FUT9 genes are expressed early in human embryogenesis". Glycobiology. 10 (8): 789–802. doi: 10.1093/glycob/10.8.789 . PMID 10929005.
Nakayama F, Nishihara S, Iwasaki H, et al. (2001). "CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV". J. Biol. Chem. 276 (19): 16100–6. doi:10.1074/jbc.M007272200. PMID 11278338.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–75. doi: 10.1074/jbc.M107927200 . PMID 11698403.
Toivonen S, Nishihara S, Narimatsu H, et al. (2003). "Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile". Glycobiology. 12 (6): 361–8. doi: 10.1093/glycob/12.6.361 . PMID 12107078.
Li H, Kong Y, Yan B (2003). "[Regulation by ovarian hormones of alpha 1,3-fucosyltransferase gene (FUT9) expression in human endometrium]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (6): 775–9. PMID 12417923.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Nishihara S, Iwasaki H, Nakajima K, et al. (2004). "Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain". Glycobiology. 13 (6): 445–55. doi:10.1093/glycob/cwg048. PMID 12626397.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Bogoevska V, Horst A, Klampe B, et al. (2006). "CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues". Glycobiology. 16 (3): 197–209. doi: 10.1093/glycob/cwj057 . PMID 16282604.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000172461 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055373 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10386598-5] Kaneko M, Kudo T, Iwasaki H, Ikehara Y, Nishihara S, Nakagawa S, Sasaki K, Shiina T, Inoko H, Saitou N, Narimatsu H (Jul 1999). "Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX". FEBS Lett. 452 (3): 237–42. doi: 10.1016/S0014-5793(99)00640-7 . PMID 10386598. S2CID 21861521.

[pmid10575236-6] Kaneko M, Kudo T, Iwasaki H, Shiina T, Inoko H, Kozaki T, Saitou N, Narimatsu H (Jan 2000). "Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization". Cytogenet Cell Genet. 86 (3–4): 329–30. doi:10.1159/000015329. PMID 10575236. S2CID 85080516.

[entrez-7] 1 2 "Entrez Gene: FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)".

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FUT9

Related Research Articles

References

Further reading