UGT1A8

UGT1A8
Identifiers
Aliases	UGT1A8 , UDPGT, UDPGT 1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H, UDP glucuronosyltransferase family 1 member A8, UGT1-01, UGT-1A, UGT1.1, UGT1A, hUG-BR1, UGT1, GNT1, UGT1A1, UDPGT 1-1
External IDs	OMIM: 606433 MGI: 3576092 HomoloGene: 133281 GeneCards: UGT1A8
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,773,300 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,146,719 bp
RNA expression pattern
	Top expressed in
	rectum; ; gallbladder; ; duodenum; ; urinary bladder; ; right lobe of liver; ; islet of Langerhans; ; appendix; ; renal cortex; ; thymus; ; kidney;
	Top expressed in
	hepatobiliary system; ; liver; ; duodenum; ; colon; ; renal cortex; ; proximal tubule; ; stomach; ; kidney; ; ileum; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; enzyme inhibitor activity ; retinoic acid binding ; hexosyltransferase activity ; protein homodimerization activity ; glycosyltransferase activity ; glucuronosyltransferase activity ; fatty acid binding ; steroid binding ; protein heterodimerization activity ; enzyme binding ; UDP-glycosyltransferase activity ;
Cellular component	integral component of membrane ; endoplasmic reticulum membrane ; membrane ; intracellular membrane-bounded organelle ; endoplasmic reticulum ;
Biological process	steroid metabolic process ; coumarin metabolic process ; negative regulation of steroid metabolic process ; retinoic acid metabolic process ; negative regulation of cellular glucuronidation ; fatty acid metabolic process ; cellular glucuronidation ; flavonoid glucuronidation ; xenobiotic glucuronidation ; flavone metabolic process ; metabolism ; negative regulation of glucuronosyltransferase activity ; negative regulation of fatty acid metabolic process ; negative regulation of catalytic activity ;
	Sources:Amigo / QuickGO
Orthologs
	54576
	394434
	ENSG00000242366
	ENSMUSG00000090175
	Q9HAW9
	Q62452
	NM_019076
	NM_201644
	NP_061949
	NP_964006
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

UDP-glucuronosyltransferase 1-8 is an enzyme that in humans is encoded by the UGT1A8 gene.^[5]^[6]^[7]

Function

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.^[5]

Related Research Articles

<span class="mw-page-title-main">Glucuronosyltransferase</span> Class of enzymes

Uridine 5'-diphospho-glucuronosyltransferase is a microsomal glycosyltransferase that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule. This is a glucuronidation reaction.

UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene.

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain. In humans, UDP-Glucuronosyltransferase-2B7 is encoded by the UGT2B7 gene.

UDP-glucuronosyltransferase 1-6 is an enzyme that in humans is encoded by the UGT1A6 gene.

UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene.

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene.

UDP-glucuronosyltransferase 1-3 is an enzyme that in humans is encoded by the UGT1A3 gene.

UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.

UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an enzyme that in humans is encoded by the UGT2B4 gene.

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.

2-hydroxyacylsphingosine 1-beta-galactosyltransferase is an enzyme that in humans is encoded by the UGT8 gene.

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.

UDP glucuronosyltransferase 1 family, polypeptide A cluster (UGT1A) is a human gene locus which includes several UDP glucuronosyltransferases.

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene. It is responsible for glucuronidation of nicotine and cotinine.

UDP-glucuronosyltransferase 1-5 is an enzyme that in humans is encoded by the UGT1A5 gene.

UDP-glucuronosyltransferase 1-9 is an enzyme that in humans is encoded by the UGT1A9 gene.

UDP glucuronosyltransferase 2 family, polypeptide B1, also known as UGT2B1, is an enzyme that in humans is encoded by the UGT2B1 gene.

UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene.

UDP glucuronosyltransferase 1 family, polypeptide A7 is a protein that in humans is encoded by the UGT1A7 gene.

Germ cell-less, spermatogenesis associated 1 is a protein that in humans is encoded by the GMCL1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000242366 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (Mar 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J Biol Chem. 267 (5): 3257–61. doi: 10.1016/S0021-9258(19)50724-4 . PMID 1339448.
↑ Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH (June 2002). "Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3". Pharmacogenetics. 12 (4): 287–97. doi:10.1097/00008571-200206000-00004. PMID 12042666.
↑ "Entrez Gene: UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8".

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000242366 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1339448-5] 1 2 Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (Mar 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J Biol Chem. 267 (5): 3257–61. doi: 10.1016/S0021-9258(19)50724-4 . PMID 1339448.

[pmid12042666-6] Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH (June 2002). "Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3". Pharmacogenetics. 12 (4): 287–97. doi:10.1097/00008571-200206000-00004. PMID 12042666.

[entrez-7] "Entrez Gene: UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8".

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