펜메토졸

Fenmetozole
펜메토졸
Fenmetozole.png
임상 데이터
ATC 코드
  • 없음.
식별자
  • 2-[(3,4-디클로로페녹시)메틸]-4,5-디히드로-1H-이미다졸
CAS 번호
PubChem CID
켐스파이더
유니
첸블
CompTox 대시보드 (EPA )
화학 및 물리 데이터
공식C10H10클론2N2O
몰 질량245.10g/140−1
3D 모델(JSmol)
  • Clc2cc(OCC/1=N/CCN\1)cc2Cl

펜메토졸(DH-524)은 항우울제로 [1][2]특허를 받은 약이지만, 결과는 좋지 않았고 일부 경우에는 [3][4][5][6][7]그 효과도 증가했지만 나중에 에탄올 효과의 길항제로서 연구되었다.이는 이다목산과 [8]같은 다른 이미다졸과 유사하게 α-아드레날린2 수용체 길항제 역할을 한다.그것은 [2]판매된 적이 없다.

페녹사졸린은 3', 4'-dich 대신 Ortho-이소프로필기를 선택했지만 정확히 동일한 공식이다.

레퍼런스

  1. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
  2. ^ a b David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.
  3. ^ McNamee HB, Mendelson JH, Korn J (June 1975). "Fenmetozole in acute alcohol intoxication in man". Clinical Pharmacology and Therapeutics. 17 (6): 735–7. doi:10.1002/cpt1975176735. PMID 1095283. S2CID 68796969.
  4. ^ Griffis LC, Bright TP, Cerimele BJ, Forney RB (September 1978). "Combined effects of fenmetozole and ethanol". Clinical Pharmacology and Therapeutics. 24 (3): 350–3. doi:10.1002/cpt1978243350. PMID 357069. S2CID 9289874.
  5. ^ Frye GD, Breese GR, Mailman RB, Vogel RA, Ondrusek MG, Mueller RA (1980). "An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function". Psychopharmacology. 69 (2): 149–55. doi:10.1007/BF00427641. PMID 6256788. S2CID 25303633.
  6. ^ Vogel RA, Frye GD, Koepke KM, Mailman RB, Mueller RA, Breese GR (1981). "Differential effects of TRH, amphetamine, naloxone, and fenmetozole on ethanol actions: attenuation of the effects of punishment and impairment of aerial righting reflex". Alcoholism: Clinical and Experimental Research. 5 (3): 386–92. doi:10.1111/j.1530-0277.1981.tb04921.x. PMID 6792942.
  7. ^ Frye GD, Breese GR (1981). "An evaluation of the locomotor stimulating action of ethanol in rats and mice". Psychopharmacology. 75 (4): 372–9. doi:10.1007/BF00435856. PMID 6803283. S2CID 34953445.
  8. ^ Stillings MR, England CD, Welbourn AP, Smith CF (September 1986). "Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists". Journal of Medicinal Chemistry. 29 (9): 1780–3. doi:10.1021/jm00159a037. PMID 2875186.