SSH2

SSH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NT2
Identifiers
Aliases	SSH2 , SSH-2, SSH-2L, slingshot protein phosphatase 2
External IDs	OMIM: 606779 MGI: 2679255 HomoloGene: 14116 GeneCards: SSH2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	29,930,276 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	77,351,046 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; blood; ; gastrocnemius muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; monocyte; ; bone marrow cells; ; sural nerve; ; thymus;
	Top expressed in
	spermatocyte; ; extraocular muscle; ; digastric muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; interventricular septum; ; soleus muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; lymph node;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity ; phosphatase activity ; actin binding ; phosphoprotein phosphatase activity ; hydrolase activity ; protein tyrosine/serine/threonine phosphatase activity ;
Cellular component	cytoplasm ; cytoskeleton ; extracellular space ;
Biological process	regulation of lamellipodium assembly ; regulation of axonogenesis ; regulation of actin polymerization or depolymerization ; protein dephosphorylation ; peptidyl-tyrosine dephosphorylation ; actin cytoskeleton organization ; dephosphorylation ; cell morphogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	85464
	237860
	ENSG00000141298
	ENSMUSG00000037926
	Q76I76
	Q5SW75
	NM_001282129 ; NM_001282130 ; NM_001282131 ; NM_033389
	NM_001291190 ; NM_177710
	NP_001269058 ; NP_001269059 ; NP_001269060 ; NP_203747
	NP_001278119 ; NP_808378
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.^[5]^[6]^[7]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]^[7]

Related Research Articles

ADF/cofilin is a family of actin-binding proteins associated with the rapid depolymerization of actin microfilaments that give actin its characteristic dynamic instability. This dynamic instability is central to actin's role in muscle contraction, cell motility and transcription regulation.

Cofilin 1 , also known as CFL1, is a human gene, part of the ADF/cofilin family.

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.

LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene.

Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.

LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.

Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.

For the SSH-1 protocol, see Secure Shell#Version 1

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.

Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.

Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.

Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene.

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.

Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.

Twinfilin-1 is a protein that in humans is encoded by the TWF1 gene. This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.

Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene.

Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene.

Dual-specificity phosphatase is a form of phosphatase that can act upon tyrosine or serine/threonine residues.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141298 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037926 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi: 10.1016/S0092-8674(01)00638-9 . PMID 11832213. S2CID 5576208.
↑ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID 11214970.
1 2 "Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)".

External links

Overview of all the structural information available in the PDB for UniProt : Q76I76 (Protein phosphatase Slingshot homolog 2) at the PDBe-KB .

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141298 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037926 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11832213-5] Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi: 10.1016/S0092-8674(01)00638-9 . PMID 11832213. S2CID 5576208.

[pmid11214970-6] Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID 11214970.

[entrez-7] 1 2 "Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)".

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SSH2

Contents

Related Research Articles

References

Further reading

External links