DUSP16

Last updated
DUSP16
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases DUSP16 , MKP-7, MKP7, dual specificity phosphatase 16
External IDs OMIM: 607175 MGI: 1917936 HomoloGene: 15604 GeneCards: DUSP16
Orthologs
SpeciesHumanMouse
Entrez

80824

70686

Ensembl

ENSG00000280962
ENSG00000111266

ENSMUSG00000030203

UniProt

Q9BY84

n/a

RefSeq (mRNA)

NM_030640

NM_001048054
NM_130447
NM_181320

RefSeq (protein)

NP_085143
NP_085143.1

n/a

Location (UCSC) Chr 12: 12.47 – 12.56 Mb Chr 6: 134.69 – 134.77 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene. [5] [6] [7] [8]

Contents

The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM] [8]

Interactions

DUSP16 has been shown to interact with MAPK14 [9] [10] and MAPK8IP1. [11]

Related Research Articles

<span class="mw-page-title-main">MAPK1</span> Protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase 1, (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.

<span class="mw-page-title-main">MAPK14</span> Protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene.

<span class="mw-page-title-main">MAPK3</span> Protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the MAPK3 gene.

<span class="mw-page-title-main">MAPK8</span> Protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase 8 is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene.

<span class="mw-page-title-main">DUSP1</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.

<span class="mw-page-title-main">MAPK8IP1</span> Protein-coding gene in the species Homo sapiens

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.

<span class="mw-page-title-main">DUSP6</span> Protein-coding gene in humans

Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene.

<span class="mw-page-title-main">MAP3K4</span> Protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene.

<span class="mw-page-title-main">MAPK8IP2</span> Protein-coding gene in the species Homo sapiens

C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it. The gene is also known as Islet-Brain-2 (IB2).

<span class="mw-page-title-main">DUSP3</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.

<span class="mw-page-title-main">DUSP4</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene.

<span class="mw-page-title-main">DUSP10</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.

<span class="mw-page-title-main">DUSP2</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP2 gene.

<span class="mw-page-title-main">DUSP7</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene.

<span class="mw-page-title-main">DUSP22</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene.

<span class="mw-page-title-main">DUSP5</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene.

<span class="mw-page-title-main">MAPK11</span> Protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene.

<span class="mw-page-title-main">DUSP12</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene.

<span class="mw-page-title-main">DUSP19</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 19 is an enzyme that in humans is encoded by the DUSP19 gene.

<span class="mw-page-title-main">MAPK phosphatase</span>

MAPK phosphatases (MKPs) are the largest class of phosphatases involved in down-regulating Mitogen-activated protein kinases (MAPK) signaling. MAPK signalling pathways regulate multiple features of development and homeostasis. This can involve gene regulation, cell proliferation, programmed cell death and stress responses. MAPK phosphatases are therefore important regulator components of these pathways.

References

  1. 1 2 3 ENSG00000111266 GRCh38: Ensembl release 89: ENSG00000280962, ENSG00000111266 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030203 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J Biol Chem. 276 (28): 26629–39. doi: 10.1074/jbc.M101981200 . PMID   11359773.
  6. ↑ Masuda K, Shima H, Watanabe M, Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J Biol Chem. 276 (42): 39002–11. doi: 10.1074/jbc.M104600200 . PMID   11489891.
  7. ↑ Willoughby EA, Collins MK (Jul 2005). "Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2". J Biol Chem. 280 (27): 25651–8. doi: 10.1074/jbc.M501926200 . PMID   15888437.
  8. 1 2 "Entrez Gene: DUSP16 dual specificity phosphatase 16".
  9. ↑ Tanoue, T; Yamamoto T; Maeda R; Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. United States. 276 (28): 26629–39. doi: 10.1074/jbc.M101981200 . ISSN   0021-9258. PMID   11359773.
  10. ↑ Masuda, K; Shima H; Watanabe M; Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J. Biol. Chem. United States. 276 (42): 39002–11. doi: 10.1074/jbc.M104600200 . ISSN   0021-9258. PMID   11489891.
  11. ↑ Willoughby, Emma A; Perkins Gordon R; Collins Mary K; Whitmarsh Alan J (Mar 2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. United States. 278 (12): 10731–6. doi: 10.1074/jbc.M207324200 . ISSN   0021-9258. PMID   12524447.

Further reading



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