PTP4A3

PTP4A3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1R6H, 1V3A, 2MBC
Identifiers
Aliases	PTP4A3 , PRL-3, PRL-R, PRL3, protein tyrosine phosphatase type IVA, member 3, protein tyrosine phosphatase 4A3
External IDs	OMIM: 606449 MGI: 1277098 HomoloGene: 22500 GeneCards: PTP4A3
Gene location (Human)
Chr.	Chromosome 8 (human)
End	141,432,454 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	73,758,766 bp
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• protein tyrosine phosphatase activity ; • prenylated protein tyrosine phosphatase activity ; • phosphatase activity ; • phosphoprotein phosphatase activity ; • hydrolase activity ; • protein tyrosine/serine/threonine phosphatase activity ; • GO:0001948 protein binding ;
Cellular component	• endosome ; • plasma membrane ; • early endosome ; • membrane ; • nucleus ; • cytoplasm ;
Biological process	• Notch signaling pathway ; • protein dephosphorylation ; • positive regulation of vascular permeability ; • regulation of vascular endothelial growth factor signaling pathway ; • endothelial cell migration ; • dephosphorylation ; • peptidyl-tyrosine dephosphorylation ; • regulation of transcription, DNA-templated ; • positive regulation of NIK/NF-kappaB signaling ; • positive regulation of establishment of protein localization ; • cellular response to leukemia inhibitory factor ;
	Sources:Amigo / QuickGO
Orthologs
	11156
	19245
	ENSG00000184489 ; ENSG00000275575
	ENSMUSG00000059895
	O75365
	Q9D658
	NM_007079 ; NM_032611
	NM_001166388 ; NM_001166389 ; NM_001166390 ; NM_008975 ; NM_001357591
	NP_009010 ; NP_116000
	NP_001159860 ; NP_001159861 ; NP_001159862 ; NP_033001 ; NP_001344520
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 13, 2021

Protein tyrosine phosphatase type IVA 3 is an enzyme that in humans is encoded by the PTP4A3 gene.^[5]

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.^[5]

Related Research Articles

Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the founding member of the protein tyrosine phosphatase (PTP) family. In humans it is encoded by the PTPN1 gene. PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes. It has also been implicated in the development of breast cancer and has been explored as a potential therapeutic target in that avenue as well.

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.

Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.

Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene.

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene, thought to be a metastasis suppressor.

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5 gene.

Receptor-type tyrosine-protein phosphatase delta is an enzyme that, in humans, is encoded by the PTPRD gene.

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.

Centromere protein H is a protein that in humans is encoded by the CENPH gene.

Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the PTPRT gene.

Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.

Transmembrane protease, serine 6 is an enzyme that in humans is encoded by the TMPRSS6 gene.

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.

Transcriptional repressor CTCFL also known as BORIS is a protein that in humans is encoded by the CTCFL gene.

Transcription factor AP-2 gamma also known as AP2-gamma is a protein that in humans is encoded by the TFAP2C gene. AP2-gamma is a member of the activating protein 2 family of transcription factors.

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.

References

1 2 3 ENSG00000275575 GRCh38: Ensembl release 89: ENSG00000184489, ENSG00000275575 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059895 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: PTP4A3 protein tyrosine phosphatase type IVA, member 3".

Zeng Q, Hong W, Tan YH (1998). "Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1". Biochem. Biophys. Res. Commun. 244 (2): 421–7. doi:10.1006/bbrc.1998.8291. PMID 9514946.
Dayton MA, Knobloch TJ (1998). "Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38". Receptors & Signal Transduction. 7 (4): 241–56. PMID 9633825.
Zeng Q, Si X, Horstmann H, et al. (2000). "Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome". J. Biol. Chem. 275 (28): 21444–52. doi: 10.1074/jbc.M000453200 . PMID 10747914.
Matter WF, Estridge T, Zhang C, et al. (2001). "Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling". Biochem. Biophys. Res. Commun. 283 (5): 1061–8. doi:10.1006/bbrc.2001.4881. PMID 11355880.
Saha S, Bardelli A, Buckhaults P, et al. (2001). "A phosphatase associated with metastasis of colorectal cancer". Science. 294 (5545): 1343–6. Bibcode:2001Sci...294.1343S. doi:10.1126/science.1065817. PMID 11598267. S2CID 42104960.
Wang J, Kirby CE, Herbst R (2003). "The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis". J. Biol. Chem. 277 (48): 46659–68. doi: 10.1074/jbc.M206407200 . PMID 12235145.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Pathak MK, Dhawan D, Lindner DJ, et al. (2003). "Pentamidine is an inhibitor of PRL phosphatases with anticancer activity". Mol. Cancer Ther. 1 (14): 1255–64. PMID 12516958.
Zeng Q, Dong JM, Guo K, et al. (2003). "PRL-3 and PRL-1 promote cell migration, invasion, and metastasis". Cancer Res. 63 (11): 2716–22. PMID 12782572.
Bardelli A, Saha S, Sager JA, et al. (2004). "PRL-3 expression in metastatic cancers". Clin. Cancer Res. 9 (15): 5607–15. PMID 14654542.
Kozlov G, Cheng J, Ziomek E, et al. (2004). "Structural insights into molecular function of the metastasis-associated phosphatase PRL-3". J. Biol. Chem. 279 (12): 11882–9. doi: 10.1074/jbc.M312905200 . PMID 14704153.
Kim KA, Song JS, Jee J, et al. (2004). "Structure of human PRL-3, the phosphatase associated with cancer metastasis". FEBS Lett. 565 (1–3): 181–7. doi: 10.1016/j.febslet.2004.03.062 . PMID 15135076. S2CID 29552515.
Wu X, Zeng H, Zhang X, et al. (2004). "Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells". Am. J. Pathol. 164 (6): 2039–54. doi:10.1016/S0002-9440(10)63763-7. PMC 1615773 . PMID 15161639.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Kato H, Semba S, Miskad UA, et al. (2005). "High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases". Clin. Cancer Res. 10 (21): 7318–28. doi: 10.1158/1078-0432.CCR-04-0485 . PMID 15534108.
Li J, Guo K, Koh VW, et al. (2005). "Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases". Clin. Cancer Res. 11 (6): 2195–204. doi: 10.1158/1078-0432.CCR-04-1984 . PMID 15788667.
Polato F, Codegoni A, Fruscio R, et al. (2006). "PRL-3 phosphatase is implicated in ovarian cancer growth". Clin. Cancer Res. 11 (19 Pt 1): 6835–9. doi: 10.1158/1078-0432.CCR-04-2357 . PMID 16203771.
Peng L, Jin G, Wang L, et al. (2006). "Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3". Biochem. Biophys. Res. Commun. 342 (1): 179–83. doi:10.1016/j.bbrc.2006.01.102. PMID 16472776.
Rouleau C, Roy A, St Martin T, et al. (2006). "Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function". Mol. Cancer Ther. 5 (2): 219–29. doi: 10.1158/1535-7163.MCT-05-0289 . PMID 16505094.
Radke I, Götte M, Kersting C, et al. (2006). "Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer". Br. J. Cancer. 95 (3): 347–54. doi:10.1038/sj.bjc.6603261. PMC 2360632 . PMID 16832410.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000275575 GRCh38: Ensembl release 89: ENSG00000184489, ENSG00000275575 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059895 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: PTP4A3 protein tyrosine phosphatase type IVA, member 3".

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PTP4A3

Related Research Articles

References

Further reading