평형 뉴클레오시드 트랜스포터 2

SLC29A2
식별자
에일리어스	SLC29A2, DER12, ENT2, HNP36, 평형 뉴클레오시드 트랜스포터2, 용질담체족 29멤버 2
외부 ID	OMIM: 602110 MGI: 1345278 HomoloGene: 37493 GenCard: SLC29A2
유전자 위치(인간)
크르.	11번 염색체(인간)
끝.	66,372,214 bp
유전자 위치(마우스)
크르.	19번 염색체(쥐)
끝.	5,031,972 bp
RNA발현패턴
	상단 표시 위치:
	위근; ; 설체; ; 외측 광대근; ; 골격근 조직; ; 좌심실; ; 상완 이두근; ; 위체; ; 췌장체; ; 상완 삼두근; ; 흉부 횡격막;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	뉴클레오시드경막수송체활성;
셀룰러 컴포넌트	막의 적분 성분; 혈장막; 기저측 혈장막; 혈장막의 적분 성분; 핵막; 핵소체; 막; 핵; 시냅스 전;
생물학적 과정	뉴클레오시드 수송; 세포군 증식; 뉴클레오시드경막수송; 핵산가수분해효소함유복합체; 아데닌수송; 구아닌수송; 우리딘 수송; 하이포산틴수송; 티민수송; 신경전달물질 재흡수;
	출처:아미고 / QuickGO
맞춤법
	3177
	13340
	ENSG0000017469
	ENSMUSG000024891
	문제 14542
	Q61672
	NM_001300868; NM_001300869; NM_001532
	NM_007854
	NP_001287797; NP_00128798; NP_001523
	NP_031880
	위키데이터
인간 보기/편집	마우스 표시/편집

평형 뉴클레오시드 트랜스포터 2(ENT2)는 SLC29A2 ^[5]^[6]^[7]유전자에 의해 인간 내에서 코드되는 단백질이다.

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^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG0000017469 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000024891 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Williams JB, Rexer B, Sirripurapu S, John S, Goldstein R, Phillips JA III, Haley LL, Sait SN, Shows TB, Smith CM, Gerhard DS (Sep 1997). "The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome". Genomics. 42 (2): 325–30. doi:10.1006/geno.1997.4751. PMID 9192854.
^ Crawford CR, Patel DH, Naeve C, Belt JA (Mar 1998). "Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line". J Biol Chem. 273 (9): 5288–93. doi:10.1074/jbc.273.9.5288. PMID 9478986.
^ "Entrez Gene: SLC29A2 solute carrier family 29 (nucleoside transporters), member 2".

추가 정보

Baldwin SA, Beal PR, Yao SY, et al. (2004). "The equilibrative nucleoside transporter family, SLC29". Pflügers Arch. 447 (5): 735–43. doi:10.1007/s00424-003-1103-2. PMID 12838422. S2CID 8817821.
Mangravite LM, Badagnani I, Giacomini KM (2004). "Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney". Eur. J. Pharmacol. 479 (1–3): 269–81. doi:10.1016/j.ejphar.2003.08.076. PMID 14612157.
Williams JB, Lanahan AA (1995). "A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein". Biochem. Biophys. Res. Commun. 213 (1): 325–33. doi:10.1006/bbrc.1995.2133. PMID 7639753.
Griffiths M, Yao SY, Abidi F, et al. (1998). "Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta". Biochem. J. 328 (3): 739–43. doi:10.1042/bj3280739. PMC 1218980. PMID 9396714.
Yao SY, Ng AM, Vickers MF, et al. (2002). "Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation". J. Biol. Chem. 277 (28): 24938–48. doi:10.1074/jbc.M200966200. PMID 12006583.
Molina-Arcas M, Bellosillo B, Casado FJ, et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia". Blood. 101 (6): 2328–34. doi:10.1182/blood-2002-07-2236. PMID 12411296.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mangravite LM, Xiao G, Giacomini KM (2003). "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells". Am. J. Physiol. Renal Physiol. 284 (5): F902–10. doi:10.1152/ajprenal.00215.2002. PMID 12527552.
Ward JL, Leung GP, Toan SV, Tse CM (2003). "Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2". Arch. Biochem. Biophys. 411 (1): 19–26. doi:10.1016/S0003-9861(02)00718-X. PMID 12590919.
Szkotak AJ, Ng AM, Man SF, et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells". J. Membr. Biol. 192 (3): 169–79. doi:10.1007/s00232-002-1073-x. PMID 12820662. S2CID 23060872.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Farré X, Guillén-Gómez E, Sánchez L, et al. (2004). "Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors". Int. J. Cancer. 112 (6): 959–66. doi:10.1002/ijc.20524. PMID 15386342. S2CID 33828164.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Visser F, Zhang J, Raborn RT, et al. (2005). "Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites". Mol. Pharmacol. 67 (4): 1291–8. doi:10.1124/mol.104.005884. PMID 15644498. S2CID 22594104.
Visser F, Baldwin SA, Isaac RE, et al. (2005). "Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters". J. Biol. Chem. 280 (12): 11025–34. doi:10.1074/jbc.M410348200. PMID 15649894.
Owen RP, Lagpacan LL, Taylor TR, et al. (2006). "Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2". Drug Metab. Dispos. 34 (1): 12–5. doi:10.1124/dmd.105.006270. PMID 16214850. S2CID 6396393.

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

이 막단백질 관련 물품은 그루브입니다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG0000017469 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000024891 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9192854-5] Williams JB, Rexer B, Sirripurapu S, John S, Goldstein R, Phillips JA III, Haley LL, Sait SN, Shows TB, Smith CM, Gerhard DS (Sep 1997). "The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome". Genomics. 42 (2): 325–30. doi:10.1006/geno.1997.4751. PMID 9192854.

[pmid9478986-6] Crawford CR, Patel DH, Naeve C, Belt JA (Mar 1998). "Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line". J Biol Chem. 273 (9): 5288–93. doi:10.1074/jbc.273.9.5288. PMID 9478986.

[entrez-7] "Entrez Gene: SLC29A2 solute carrier family 29 (nucleoside transporters), member 2".

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