SLC22A8

SLC22A8
식별자
별칭	SLC22A8, OAT3, solute carrier family 22 멤버 8
외부 ID	OMIM: 607581 MGI: 1336187 호몰로진: 20901 GeneCard: SLC22A8
유전자 위치(인간)
쳇.	11번 염색체(인간)
끝	63,015,841 bp
유전자 위치(마우스)
쳇.	19번 염색체(쥐)
끝	8,611,835 bp
RNA 표현 패턴
	표현된 상단
	망막색소 상피; ; 신장 튜울레; ; 콩팥을; ; 신장 피질; ; 메타네프릭 글로머룰루스; ; 광대뼈근육; ; 신간문장;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	나트륨 독립적인 유기 음이온 투과체 전달 활동; GO:0022891 트랜섬브레인 트랜스포터 활동; 무기 음이온 교환기 활동; 수송 활동; 음이온:음이온 항정신병자 활동;
셀룰러 컴포넌트	막의 적분 성분; 플라즈마 막; 근측 플라스마 막; 플라스마 막의 적분 성분; 세포외 외성체; 막으로 막다;
생물학적 과정	나트륨 독립적인 유기 음이온 수송; 이온 수송; 독성 물질에 대한 반응; 트랜스엠브레인 수송; 음이온 투과 전송; 무기 음이온 수송; 운송;
	출처:아미고 / 퀵고
직교체
	9376
	19879
	ENSG00000149452
	ENSMUSG000063796
	Q8TCC7
	O88909
	NM_001184732; NM_001184733; NM_001184736; NM_004254
	NM_001164634; NM_001164635; NM_031194
	NP_001171661; NP_001171662; NP_001171665; NP_004245
	NP_001158106; NP_001158107; NP_112471
	위키다타
인간 보기/편집	마우스 보기/편집

솔루트 캐리어 패밀리 22 멤버 8 또는 유기 음이온 트랜스포터 3(OAT3)은 인간에서 SLC22A8 유전자에 의해 인코딩되는 단백질이다.^[5]^[6]^[7]

함수

OAT3는 유기 이온의 운반과 배설에 관여하는데, 그 중 일부는 약물(예: 페니실린 G(벤지엘피닐린), 메토트렉산염(MTX), 인도메타신(NSAID), 시프로플로크사신(플루오로퀴놀론 항생제)이며, 일부는 순수한 독성물질이다.^[6]SLC22A8(OAT3)은 체토솔에 디카르복실산염 재진입하는 원동력인 내부 나트륨 경사로에 간접적으로 의존한다.세포 내에서 생성되거나 세포외 공간에서 재활용된 알파-케토글루타레이트 같은 디카르복실레이트는 그들의 농도 경사에 대항하여 유기 음이온의 유입을 부채질하는 교환 기판으로 사용된다.인코딩된 단백질은 일체형 막 단백질이며 신장 근위부 관상세포의 근측막으로 국부화 되어 있는 것으로 보인다.^[7]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000149452 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000063796 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999). "Molecular Cloning and Characterization of Two Novel Human Renal Organic Anion Transporters (hOAT1 and hOAT3)". Biochemical and Biophysical Research Communications. 255 (2): 508–14. doi:10.1006/bbrc.1998.9978. PMID 10049739.
^ ^a ^b VanWert AL, Gionfriddo MR, Sweet DH (2009). "Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology". Biopharmaceutics & Drug Disposition. 31 (1): 1–71. doi:10.1002/bdd.693. PMID 19953504.
^ ^a ^b 엔트레스제네 9376

추가 읽기

Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H (2002). "Human Organic Anion Transporters Mediate the Transport of Tetracycline". The Japanese Journal of Pharmacology. 88 (1): 69–76. doi:10.1254/jjp.88.69. PMID 11855680.
Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, Fukatsu A, Ogawa O, Inui K (2002). "Gene expression levels and immunolocalization of organic ion transporters in the human kidney". Journal of the American Society of Nephrology. 13 (4): 866–74. doi:10.1681/ASN.V134866. PMID 11912245.
Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, et al. (2003). "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics". Clinical Pharmacology & Therapeutics. 73 (6): 554–65. doi:10.1016/S0009-9236(03)00060-2. PMID 12811365. S2CID 6570648.
Bakhiya A, Bahn A, Burckhardt G, Wolff N (2003). "Human Organic Anion Transporter 3 (hOAT3) can Operate as an Exchanger and Mediate Secretory Urate Flux". Cellular Physiology and Biochemistry. 13 (5): 249–56. doi:10.1159/000074539. PMID 14586168. S2CID 24494954.
Sakurai Y, Motohashi H, Ueo H, Masuda S, Saito H, Okuda M, Mori N, Matsuura M, et al. (2004). "Expression Levels of Renal Organic Anion Transporters (OATs) and Their Correlation with Anionic Drug Excretion in Patients with Renal Diseases". Pharmaceutical Research. 21 (1): 61–7. doi:10.1023/B:PHAM.0000012153.71993.cb. hdl:2433/144752. PMID 14984259. S2CID 28592120.
Srimaroeng C, Chatsudthipong V, Aslamkhan AG, Pritchard JB (2004). "Transport of the Natural Sweetener Stevioside and Its Aglycone Steviol by Human Organic Anion Transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)". Journal of Pharmacology and Experimental Therapeutics. 313 (2): 621–8. doi:10.1124/jpet.104.080366. PMID 15644426. S2CID 15017941.
Tahara H, Shono M, Kusuhara H, Kinoshita H, Fuse E, Takadate A, Otagiri M, Sugiyama Y (2005). "Molecular Cloning and Functional Analyses of OAT1 and OAT3 from Cynomolgus Monkey Kidney". Pharmaceutical Research. 22 (4): 647–60. doi:10.1007/s11095-005-2503-0. PMID 15846473. S2CID 26613337.
Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, et al. (2005). "The human organic anion transporter 3 (OAT3; SLC22A8): Genetic variation and functional genomics". AJP: Renal Physiology. 290 (4): F905–12. doi:10.1152/ajprenal.00272.2005. PMID 16291576. S2CID 858402.
Tahara H, Kusuhara H, Maeda K, Koepsell H, Fuse E, Sugiyama Y (2006). "Inhibition of Oat3-Mediated Renal Uptake As a Mechanism for Drug-Drug Interaction Between Fexofenadine and Probenecid". Drug Metabolism and Disposition. 34 (5): 743–7. doi:10.1124/dmd.105.008375. PMID 16455804. S2CID 7695728.
Bhatnagar V, Xu G, Hamilton BA, Truong DM, Eraly SA, Wu W, Nigam SK (2006). "Analyses of 5′ regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3)". Journal of Human Genetics. 51 (6): 575–80. doi:10.1007/s10038-006-0398-1. PMID 16648942.
Kikuchi R, Kusuhara H, Hattori N, Shiota K, Kim I, Gonzalez FJ, Sugiyama Y (2006). "Regulation of the Expression of Human Organic Anion Transporter 3 by Hepatocyte Nuclear Factor 1 /beta and DNA Methylation". Molecular Pharmacology. 70 (3): 887–96. doi:10.1124/mol.106.025494. PMID 16793932. S2CID 2993122.
Mizuno N, Takahashi T, Iwase Y, Kusuhara H, Niwa T, Sugiyama Y (2007). "Human Organic Anion Transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) Transport Edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and Its Sulfate Conjugate". Drug Metabolism and Disposition. 35 (8): 1429–34. doi:10.1124/dmd.106.013912. PMID 17502342. S2CID 13006597.
Matsumoto S, Yoshida K, Ishiguro N, Maeda T, Tamai I (2007). "Involvement of Rat and Human Organic Anion Transporter 3 in the Renal Tubular Secretion of Topotecan [(S)-9-Dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride]". Journal of Pharmacology and Experimental Therapeutics. 322 (3): 1246–52. doi:10.1124/jpet.107.123323. PMID 17556638. S2CID 43487664.
Nozaki Y, Kusuhara H, Kondo T, Iwaki M, Shiroyanagi Y, Nakayama H, Horita S, Nakazawa H, et al. (2007). "Species Difference in the Inhibitory Effect of Nonsteroidal Anti-Inflammatory Drugs on the Uptake of Methotrexate by Human Kidney Slices". Journal of Pharmacology and Experimental Therapeutics. 322 (3): 1162–70. doi:10.1124/jpet.107.121491. PMID 17578901. S2CID 20950205.
Vanwert AL, Bailey RM, Sweet DH (2007). "Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G". AJP: Renal Physiology. 293 (4): F1332–41. doi:10.1152/ajprenal.00319.2007. PMC 2820253. PMID 17686950.
VanWert AL, Sweet DH (2007). "Impaired Clearance of Methotrexate in Organic Anion Transporter 3 (Slc22a8) Knockout Mice: A Gender Specific Impact of Reduced Folates". Pharmaceutical Research. 25 (2): 453–62. doi:10.1007/s11095-007-9407-0. PMC 2820254. PMID 17660957.
Windass AS, Lowes S, Wang Y, Brown CD (2007). "The Contribution of Organic Anion Transporters OAT1 and OAT3 to the Renal Uptake of Rosuvastatin". Journal of Pharmacology and Experimental Therapeutics. 322 (3): 1221–7. doi:10.1124/jpet.107.125831. PMID 17585018. S2CID 24479885.

11번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000149452 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000063796 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10049739-5] Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999). "Molecular Cloning and Characterization of Two Novel Human Renal Organic Anion Transporters (hOAT1 and hOAT3)". Biochemical and Biophysical Research Communications. 255 (2): 508–14. doi:10.1006/bbrc.1998.9978. PMID 10049739.

[review-6] VanWert AL, Gionfriddo MR, Sweet DH (2009). "Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology". Biopharmaceutics & Drug Disposition. 31 (1): 1–71. doi:10.1002/bdd.693. PMID 19953504.

[entrez-7] 엔트레스제네 9376

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SLC22A8

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