NUAK1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | NUAK1 , ARK5, NUAK family kinase 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 608130 MGI: 1925226 HomoloGene: 8896 GeneCards: NUAK1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene. [5] [6] [7]
Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. [8]
ARK5 is important in tumor malignancy and invasiveness. [9]
ARK5 is often overexpressed in multiple myeloma cell lines. [10] [11] ARK5 promotes tumor cell survival under regulation by Akt. [9]
ARK5 increases MT1-MMP production. [9] (MT1-MMP activates MMP-2 and MMP-9 which are involved in tumor metastasis. [9] )
ON123300 (a CDK4 inhibitor), also inhibits ARK5 and reduces proliferation of multiple myeloma and mantle cell lymphoma cell lines. [10]
NUAK1 has been shown to interact with USP9X [12] and Ubiquitin C. [12]
5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.
Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is encoded by the MAP3K14 gene.
Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.
Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.
MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene.
Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.
Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the LATS1 gene.
Transforming acidic coiled-coil-containing protein 2 is a protein that in humans is encoded by the TACC2 gene.
Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.
Serine/threonine-protein kinase TAO1 is an enzyme that in humans is encoded by the TAOK1 gene.
Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.
Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.
Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.
NUAK family SNF1-like kinase 2 also known as SNF1/AMP kinase-related kinase (SNARK) is an enzyme that in humans is encoded by the NUAK2 gene. Its deficiency in humans causes anencephaly, a severe form of anterior neural tube defect that curtails brain development.
Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene.
Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.
Lethal(2) giant larvae protein homolog 1 is a protein that in humans is encoded by the LLGL1 gene.
Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.
T-cell leukemia/lymphoma protein 1B is a protein that in humans is encoded by the TCL1B gene.