GPRC5A

GPRC5A
Identifiers
Aliases	GPRC5A , GPCR5A, RAI3, RAIG1, PEIG-1, TIG1, G protein-coupled receptor class C group 5 member A
External IDs	OMIM: 604138 MGI: 1891250 HomoloGene: 2961 GeneCards: GPRC5A
Gene location (Human)
Chr.	Chromosome 12 (human)
End	12,917,937 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	135,061,707 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; lower lobe of lung; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; mucosa of urinary bladder; ; visceral pleura; ; rectum; ; periodontal fiber; ; palpebral conjunctiva;
	Top expressed in
	right lung lobe; ; left lung lobe; ; large intestine; ; colon; ; epithelium of stomach; ; left colon; ; renal calyx; ; morula; ; blastocyst; ; trachea;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity ; protein binding ; signal transducer activity ; cadherin binding ; protein kinase activator activity ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; extracellular exosome ; cytoplasmic vesicle membrane ; intracellular membrane-bounded organelle ; membrane ; cytoplasmic vesicle ; vesicle ; nucleolus ; receptor complex ;
Biological process	negative regulation of epidermal growth factor-activated receptor activity ; G protein-coupled receptor signaling pathway ; signal transduction ; activation of protein kinase activity ;
	Sources:Amigo / QuickGO
Orthologs
	9052
	232431
	ENSG00000013588
	ENSMUSG00000046733
	Q8NFJ5
	Q8BHL4
	NM_003979
	NM_181444
	NP_003970
	NP_852109
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 10, 2024

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.^[5]^[6] This gene and its encoded mRNA was first identified as a phorbol ester-induced gene, and named Phorbol Ester Induced Gen 1 (PEIG-1);^[7] two years later it was rediscovered as a retinoic acid-inducible gene, and named Retinoic Acid-Inducible Gene 1 (RAIG1).^[5] Its encoded protein was later named Retinoic acid-induced protein 3.

Function

This gene encodes a member of the type 3 G protein-coupled receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoic acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.^[6] Tryptamine and other indole related chemicals produced by gut microflora bind and activate the receptor.^[8]

Post transcriptional regulation

GPRC5A is one of only a handful of genes known in the literature that are post-transcriptionally controlled by miRNAs through their 5'UTR.^[9]

Clinical significance

GPRC5A is dysregulated in many human cancers and in other diseases.^[10]

Related Research Articles

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BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.

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Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene. LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene. The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

G-protein coupled receptor family C group 5 member B is a protein that in humans is encoded by the GPRC5B gene.

G-protein coupled receptor family C group 5 member C is a protein that in humans is encoded by the GPRC5C gene.

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Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.

Cornifin-B is a protein that in humans is encoded by the SPRR1B gene.

Golgin-45 is a protein that in humans is encoded by the BLZF1 gene.

Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000013588 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046733 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi: 10.1074/jbc.273.52.35008 . PMID 9857033.
1 2 "Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A".
↑ Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1996). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells". Cell. Mol. Biol. (Noisy-le-grand). 42 (5): 797–804. PMID 8832110.
↑ Goldstein DR (2004). "Toll-like receptors and other links between innate and acquired alloimmunity". Current Opinion in Immunology. 16 (5): 538–544. doi:10.1016/j.coi.2004.08.001. PMID 15341996.
↑ Zhou H, Rigoutsos I (2014). "MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells". RNA. 20 (9): 1431–9. doi:10.1261/rna.045757.114. PMC 4138326 . PMID 24984703.
↑ Zhou H, Rigoutsos I (2014). "The emerging roles of GPRC5A in diseases". Oncoscience. 1 (12): 765–76. doi:10.18632/oncoscience.104. PMC 4303886 . PMID 25621293.

External links

"GPRC5 Receptors: RAIG₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2015-02-03. Retrieved 2008-12-04.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000013588 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046733 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9857033-5] 1 2 Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi: 10.1074/jbc.273.52.35008 . PMID 9857033.

[entrez-6] 1 2 "Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A".

[pmid8832110-7] Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1996). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells". Cell. Mol. Biol. (Noisy-le-grand). 42 (5): 797–804. PMID 8832110.

[journal-8] Goldstein DR (2004). "Toll-like receptors and other links between innate and acquired alloimmunity". Current Opinion in Immunology. 16 (5): 538–544. doi:10.1016/j.coi.2004.08.001. PMID 15341996.

[pmid24984703-9] Zhou H, Rigoutsos I (2014). "MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells". RNA. 20 (9): 1431–9. doi:10.1261/rna.045757.114. PMC 4138326 . PMID 24984703.

[pmid25621293-10] Zhou H, Rigoutsos I (2014). "The emerging roles of GPRC5A in diseases". Oncoscience. 1 (12): 765–76. doi:10.18632/oncoscience.104. PMC 4303886 . PMID 25621293.

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