| ADGRF3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | ADGRF3 , PGR23, hGPCR37, GPR113, adhesion G protein-coupled receptor F3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2685887 HomoloGene: 17826 GeneCards: ADGRF3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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GPR113 is a gene that encodes the Probable G-protein coupled receptor 113 protein. [5] [6]
The Homo sapiens GPR113 gene is located on chromosome 2 (2p23.3). This gene spans the length of a 38.65kb region from base 26531041 to 26569685 on the negative strand. [7] The GPR113 gene has two neighbors on either side on the negative strand: OTOF otoferlin preceding and HADHA hydroxyacyl-CoA following. Directly opposite the GPR113 on the positive strand is the EPT1 gene. The GPR113 gene is also known by the aliases PGR23 and HGPCR37. [8]
The GPR113 has 5 human paralogs GPR110, GPR115, GPR128, GPR111, and GPR116. [8] GPR113 is well conserved in mammals from primates to semi-aquatic species, as well as some amphibians. These include the Common Chimpanzee, the African Bush Elephant, the Platypus, and the Western Clawed Frog. [9] Homologous domains that are well conserved throughout orthologs center in the 7 transmembrane receptor (Secretin family) region highlighted in purple in the figure. [10]
The protein product of GPR113 gene is a G-protein coupled receptor. The protein has three transcript variants in humans. [11] Of these three, GPR113 Variant 1 has the longest amino acid sequence, and has the highest identity to orthologs. This leads to the conclusion that GPR113 Variant 1 is the homo sapiens descendant of the ancestral GPR113 gene. GPR113 Var 1 contains 1079 Amino Acids, and is integral to the plasma membrane. [12] The 7-pass receptor contains 4 domains highlighted in the figure at right: Signal Peptide (Red), Hormone Receptor Domain (Blue), Latrophilin/CL-1-like GPS domain (Orange), and the 7-transmembrane receptor (Purple). Between the Hormone Receptor Domain and the GPS is a Domain of unknown function that is not highlighted.
GPR113 is a G protein-coupled receptor that is involved in a neuropeptide signaling pathway. [12]
GPR113 has been found to be expressed differentially under diseased conditions. Under the condition of Type 2 diabetes, the percentile rank relative to other transcripts decreases relative to normal cell function. [13] The deletion of TP63, which mediates a wide variety of important body processes, also produces decreased GPR113 expression. [14] In mice brains, the cerebellum and the olfactory bulb both show transcription of the GPR113 gene. [15] Additionally, a study from the National Institute of Deafness and Other Communication Disorders has identified GPR113 expression to be highly restricted to a subset of taste receptor cells. [16] This paper's conclusions, coupled with olfactory bulb expression levels, could provide an avenue for future research, potentially illuminating more about GPR113's function.
GPR113 has been shown to associate with the orphan G protein-coupled receptor GPR123. [17]
| Top 10 Transcription factors of highest likelihood [18] |
|---|
| Binding site for S8 type homeodomains |
| Binding site for S8 type homeodomains |
| DLX-1, -2, and -5 binding sites |
| TCF/LEF-1 (secondary DNA binding preference) |
| Homeobox containing germ cell-specific transcription factor NOBOX |
| Spalt-like transcription factor 1 |
| Transcriptional repressor CDP |
| Alternative splicing variant of FOXP1, activated in ESCs |
| Binding site for S8 type homeodomains |
| Homeobox containing germ cell-specific transcription factor NOBOX |
The clinical significance of this protein has not been established. However, the expression profiles provide exciting directions for future research of the GPR113 gene, especially in fields studying taste and smell.
ADGRV1, also known as G protein-coupled receptor 98 (GPR98) or Very Large G-protein coupled receptor 1 (VLGR1), is a protein that in humans is encoded by the GPR98 gene. Several alternatively spliced transcripts have been described.
Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene. It is a member of the adhesion-GPCR family of receptors.
Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.
Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.
Latrophilin 1 is a protein that in humans is encoded by the ADGRL1 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene.
Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
G protein-coupled receptor 126 also known as VIGR and DREG is a protein encoded by the ADGRG6 gene. GPR126 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene. It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene. GPR128 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Adhesion G-protein coupled receptor A3 (ADGRA3), also known as GPR125, is an adhesion GPCR that in humans is encoded by the Adgra3 gene.
G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene. GPR114 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Probable G-protein coupled receptor 115 is a protein that in humans is encoded by the GPR115 gene.
Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene. GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.
Probable G-protein coupled receptor 111 is a protein that in humans is encoded by the GPR111 gene.
Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.
Probable G-protein coupled receptor 144 is a protein that in humans is encoded by the GPR144 gene. This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterised by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
EGF, latrophilin and seven transmembrane domain-containing protein 1 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this protein is encoded by the ELTD1 gene. ELTD1 appears to have a role in angiogenesis, both physiological and pathological in cancer.
Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.
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