FGF14

FGF14
Identifiers
Aliases	FGF14 , FGF-14, FHF-4, FHF4, SCA27, fibroblast growth factor 14
External IDs	OMIM: 601515 MGI: 109189 HomoloGene: 3037 GeneCards: FGF14
Gene location (Human)
Chr.	Chromosome 13 (human)
End	102,402,457 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	124,914,539 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; middle temporal gyrus; ; bronchial epithelial cell; ; Brodmann area 23; ; cerebellar vermis; ; endothelial cell; ; postcentral gyrus; ; superior frontal gyrus; ; entorhinal cortex; ; cerebellar hemisphere;
	Top expressed in
	barrel cortex; ; cerebellar vermis; ; olfactory tubercle; ; mammillary body; ; superior frontal gyrus; ; suprachiasmatic nucleus; ; supraoptic nucleus; ; nucleus accumbens; ; ventromedial nucleus; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	fibroblast growth factor receptor binding ; growth factor activity ; heparin binding ; protein binding ;
Cellular component	extracellular region ; nucleus ; intracellular anatomical structure ;
Biological process	regulation of synaptic vesicle recycling ; JNK cascade ; cell-cell signaling ; fibroblast growth factor receptor signaling pathway ; regulation of postsynaptic membrane potential ; signal transduction ; nervous system development ; regulation of synaptic plasticity ; positive regulation of high voltage-gated calcium channel activity ; regulation of signaling receptor activity ;
	Sources:Amigo / QuickGO
Orthologs
	2259
	14169
	ENSG00000102466
	ENSMUSG00000025551
	Q92915
	P70379
NM_004115 ; NM_175929 ; NM_001321931 ; NM_001321932 ; NM_001321933 ;
	NM_001321934 ; NM_001321935 ; NM_001321936 ; NM_001321937 ; NM_001321938 ; NM_001321939 ; NM_001321940 ; NM_001321941 ; NM_001321942 ; NM_001321943 ; NM_001321944 ; NM_001321945 ; NM_001321946 ; NM_001321947 ; NM_001321948 ; NM_001321949 ; NM_001379342 Contents Relationship with Alzheimer's disease ; References ; Further reading ;
	NM_010201 ; NM_207667
NP_001308860 ; NP_001308861 ; NP_001308862 ; NP_001308863 ; NP_001308864 ;
	NP_001308865 ; NP_001308866 ; NP_001308867 ; NP_001308868 ; NP_001308869 ; NP_001308870 ; NP_001308871 ; NP_001308872 ; NP_001308873 ; NP_001308874 ; NP_001308875 ; NP_001308876 ; NP_001308877 ; NP_001308878 ; NP_004106 ; NP_787125 ; NP_001366271
	NP_034331 ; NP_997550
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 08, 2023

Fibroblast growth factor 14 is a biologically active protein that in humans is encoded by the FGF14 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.^[7]

FGF14 is mainly expressed in the central nervous system and is associated with neurodegenerative diseases such as spinocerebellar ataxia (SCA27). FGF14 deficiency also impairs the maturation of cells in the hippocampus, which is possibly related to the development of schizophrenia.^[8]

Relationship with Alzheimer's disease

FGF14 levels are elevated in patients with Alzheimer's disease. FGF14 messenger RNA was also found to be upregulated in Alzheimer's patients, which suggests that it is involved in the pathogenesis of the disease, although the underlying mechanism is still unknown. Research is ongoing as to whether or not FGF14 could be used as a therapy against Alzheimer's disease as well as other neurodegenerative diseases, by promote neural proliferation and regulating the plasticity of the synapses.

Related Research Articles

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

Fibroblast growth factor 23 (FGF23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate in plasma and vitamin D metabolism. In humans it is encoded by the FGF23 gene. FGF23 decreases reabsorption of phosphate in the kidney. Mutations in FGF23 can lead to its increased activity, resulting in autosomal dominant hypophosphatemic rickets.

Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10. FGFR2 is a receptor for fibroblast growth factor.

Tyrosyl-DNA phosphodiesterase 1 is an enzyme that in humans is encoded by the TDP1 gene.

Fibroblast growth factor 5 is a protein that in humans is encoded by the FGF5 gene.

Elongation of very long chain fatty acids protein 4 is a protein that in humans is encoded by the ELOVL4 gene.

<span class="mw-page-title-main">Alpha-tocopherol transfer protein</span> Protein-coding gene in the species Homo sapiens

Alpha-tocopherol transfer protein (α-TTP) is a protein that in humans is encoded by the TTPA gene.

Fibroblast growth factor 18 is a protein that in humans is encoded by the FGF18 gene.

Ataxin-10 is a protein that in humans is encoded by the ATXN10 gene.

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.

Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene.

Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.

Puratrophin-1 is a protein that in humans is encoded by the PLEKHG4 gene.

Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene.

Potassium voltage-gated channel, Shaw-related subfamily, member 3 also known as KCNC3 or K_v3.3 is a protein that in humans is encoded by the KCNC3.

Fibroblast growth factor 11 also known as FGF11 is a human gene.

Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans.

Autosomal dominant cerebellar ataxia (ADCA) is a form of spinocerebellar ataxia inherited in an autosomal dominant manner. ADCA is a genetically inherited condition that causes deterioration of the nervous system leading to disorder and a decrease or loss of function to regions of the body.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102466 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025551 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A. 93 (18): 9850–7. Bibcode:1996PNAS...93.9850S. doi: 10.1073/pnas.93.18.9850 . PMC 38518 . PMID 8790420.
↑ Wozniak DF, Xiao M, Xu L, Yamada KA, Ornitz DM (Mar 2007). "Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14". Neurobiol Dis. 26 (1): 14–26. doi:10.1016/j.nbd.2006.11.014. PMC 2267915 . PMID 17236779.
1 2 "Entrez Gene: FGF14 fibroblast growth factor 14".
↑ Wang, Lusheng; Jing, Rongrong; Wang, Xing; Wang, Baohui; Guo, Keke; Zhao, Jungang; Gao, Shuang; Xu, Nuo; Xuan, Xuan (June 2021) [11 June 2021]. "A method for the expression of fibroblast growth factor 14 and assessment of its neuroprotective effect in an Alzheimer's disease model". Annals of Translational Medicine. 9 (12): 994. doi:10.21037/atm-21-2492. ISSN 2305-5839. PMC 8267273 . PMID 34277794.

Wang Q, Bardgett ME, Wong M, et al. (2002). "Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14". Neuron. 35 (1): 25–38. doi: 10.1016/S0896-6273(02)00744-4 . PMID 12123606.
Chumakov I, Blumenfeld M, Guerassimenko O, et al. (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675–80. Bibcode:2002PNAS...9913675C. doi: 10.1073/pnas.182412499 . PMC 129739 . PMID 12364586.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
van Swieten JC, Brusse E, de Graaf BM, et al. (2003). "A Mutation in the Fibroblast Growth Factor 14 Gene Is Associated with Autosomal Dominant Cerebral Ataxia". Am. J. Hum. Genet. 72 (1): 191–9. doi:10.1086/345488. PMC 378625 . PMID 12489043.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288 . PMID 15057823.
Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J. Biol. Chem. 279 (38): 40146–52. doi: 10.1074/jbc.M405795200 . PMID 15199049.
Stevanin G, Durr A, Dussert C, et al. (2005). "Mutations in the FGF14 gene are not a major cause of spinocerebellar ataxia in Caucasians". Neurology. 63 (5): 936. doi:10.1212/01.wnl.0000137020.30604.1e. PMID 15365159. S2CID 35093587.
Dalski A, Atici J, Kreuz FR, et al. (2005). "Mutation analysis in the fibroblast growth factor 14 gene: frameshift mutation and polymorphisms in patients with inherited ataxias". Eur. J. Hum. Genet. 13 (1): 118–20. doi: 10.1038/sj.ejhg.5201286 . PMID 15470364.
Lou JY, Laezza F, Gerber BR, et al. (2006). "Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels". J. Physiol. 569 (Pt 1): 179–93. doi:10.1113/jphysiol.2005.097220. PMC 1464207 . PMID 16166153.
Brusse E, de Koning I, Maat-Kievit A, et al. (2006). "Spinocerebellar ataxia associated with a mutation in the fibroblast growth factor 14 gene (SCA27): A new phenotype". Mov. Disord. 21 (3): 396–401. doi:10.1002/mds.20708. PMID 16211615. S2CID 25438944.
Zhao Y, Lim SW, Tan EK (2007). "Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (3): 395–6. doi:10.1002/ajmg.b.30472. PMID 17221845. S2CID 41536996.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102466 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025551 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8790420-5] Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A. 93 (18): 9850–7. Bibcode:1996PNAS...93.9850S. doi: 10.1073/pnas.93.18.9850 . PMC 38518 . PMID 8790420.

[pmid17236779-6] Wozniak DF, Xiao M, Xu L, Yamada KA, Ornitz DM (Mar 2007). "Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14". Neurobiol Dis. 26 (1): 14–26. doi:10.1016/j.nbd.2006.11.014. PMC 2267915 . PMID 17236779.

[entrez-7] 1 2 "Entrez Gene: FGF14 fibroblast growth factor 14".

[8] Wang, Lusheng; Jing, Rongrong; Wang, Xing; Wang, Baohui; Guo, Keke; Zhao, Jungang; Gao, Shuang; Xu, Nuo; Xuan, Xuan (June 2021) [11 June 2021]. "A method for the expression of fibroblast growth factor 14 and assessment of its neuroprotective effect in an Alzheimer's disease model". Annals of Translational Medicine. 9 (12): 994. doi:10.21037/atm-21-2492. ISSN 2305-5839. PMC 8267273 . PMID 34277794.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

FGF14

Contents

Relationship with Alzheimer's disease

Related Research Articles

References

Further reading