Amidorfin
Amidorfin | |||
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Identifikacija | |||
CAS registarski broj | 94885-44-6 | ||
PubChem[1][2] | 16132380 | ||
ChemSpider[3] | 17289039 | ||
Jmol-3D slike | Slika 1 | ||
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Svojstva | |||
Molekulska formula | C131H200N30O43S2 | ||
Molarna masa | 2947.29 g/mol | ||
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Infobox references |
Amidorfin je endogeni, C-terminalno amidisani, opioidni oktapeptid koji nastaje proteolitičim presecanjem proenkefalina A. Adrenorfin je široko rasprostranjen u mozgu sisara. Posebno visoke koncentracije su nađene u adrenalnoj meduli, posteriornoj hipofizi, i strijatumu.[4][5] U nekim oblastima mozga, amidorfin je intenzivno dalje redukovan u manje fragmente, kao što su ne-opioidni peptid amidorfin-(8-26), kome nedostaje N-terminalna Met-enkefalinska sekvenca amidorfina. Met-enkefalin može takođe da bude proizvod presecanja amidorfina.[6]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Seizinger BR, Liebisch DC, Gramsch C, et al. (1985). „Isolation and structure of a novel C-terminally amidated opioid peptide, amidorphin, from bovine adrenal medulla”. Nature 313 (5997): 57–9. PMID 3965972.
- ↑ Liebisch DC, Seizinger BR, Michael G, Herz A (November 1985). „Novel opioid peptide amidorphin: characterization and distribution of amidorphin-like immunoreactivity in bovine, ovine, and porcine brain, pituitary, and adrenal medulla”. Journal of Neurochemistry 45 (5): 1495–503. PMID 4045460.
- ↑ Liebisch DC, Weber E, Kosicka B, Gramsch C, Herz A, Seizinger BR (March 1986). „Isolation and structure of a C-terminally amidated nonopioid peptide, amidorphin-(8-26), from bovine striatum: a major product of proenkephalin in brain but not in adrenal medulla”. Proceedings of the National Academy of Sciences of the United States of America 83 (6): 1936–40. PMC 323199. PMID 3456613.