TRIMU 5
TRIMU 5 | |||
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IUPAC ime |
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Drugi nazivi | (2S)-2-amino-3-(4-hydroxyphenyl)-N-[(2R)-1[2-(3-methylbutylamino)acetyl]amino1-oxopropan-2-yl]propanamide | ||
Identifikacija | |||
CAS registarski broj | 90815-77-3 | ||
PubChem[1][2] | 5487273 | ||
ChemSpider[3] | 21106389 ![]() | ||
Jmol-3D slike | Slika 1 | ||
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Svojstva | |||
Molekulska formula | C19H30N4O4 | ||
Molarna masa | 378.466 | ||
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
TRIMU 5 je selektivni μ2-agonist/μ1-antagonist mi opioidnog receptora. On stimuliše hipotalamo-hipofizno-adrenalnu osu.[4][5] U eksprerimentima na pacovima TRIMU-5, 50 μg, proizvodi održiv porast kortikosterona u plazmi u toku tročasovnog perioda. Niže doze (10 μg) ne proizvode respons, dok veće doze (100 μg) povišavaju hormonski odgovor, ali su letalne u 50% slučajeva.[4]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ 4,0 4,1 Eisenberg RM (1994). „TRIMU-5, a mi 2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis”. Pharmacol. Biochem. Behav. 47 (4): 943–6. DOI:10.1016/0091-3057(94)90300-X. PMID 8029266.
- ↑ Tive LA, Pick CG, Paul D, Roques BP, Gacel GA, Pasternak GW. (1992). „Analgesic potency of TRIMU-5: a mixed mu 2 opioid receptor agonist/mu 1 opioid receptor antagonist”. Eur J Pharmacol. 216 (2): 249-55. PMID 1327812.