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Shugoshin-liki prorein 2 (S. pombe ) SGOL2, jest protein koji je kod ljudi kodiran genom SGOL2 jest protein koji je kod ljudi kodiran genom sa hromosoma 2 .[ 5] [ 6]
Dužina polipeptidnog lanca je 1.265 aminokiselina , a molekulska težina 144.739 Da .[ 7]
10 20 30 40 50 MECPVMETGS LFTSGIKRHL KDKRISKTTK LNVSLASKIK TKILNNSSIF KISLKHNNRA LAQALSREKE NSRRITTEKM LLQKEVEKLN FENTFLRLKL NNLNKKLIDI EALMNNNLIT AIEMSSLSEF HQSSFLLSAS KKKRISKQCK LMRLPFARVP LTSNDDEDED KEKMQCDNNI KSKTLPDIPS SGSTTQPLST QDNSEVLFLK ENNQNVYGLD DSEHISSIVD VPPRESHSHS DQSSKTSLMS EMRNAQSIGR RWEKPSPSNV TERKKRGSSW ESNNLSADTP CATVLDKQHI SSPELNCNNE INGHTNETNT EMQRNKQDLP GLSSESAREP NAECMNQIED NDDFQLQKTV YDADMDLTAS EVSKIVTVST GIKKKSNKKT NEHGMKTFRK VKDSSSEKKR ERSKRQFKNS SDVDIGEKIE NRTERSDVLD GKRGAEDPGF IFNNEQLAQM NEQLAQVNEL KKMTLQTGFE QGDRENVLCN KKEKRITNEQ EETYSLSQSS GKFHQESKFD KGQNSLTCNK SKASRQTFVI HKLEKDNLLP NQKDKVTIYE NLDVTNEFHT ANLSTKDNGN LCDYGTHNIL DLKKYVTDIQ PSEQNESNIN KLRKKVNRKT EIISGMNHMY EDNDKDVVHG LKKGNFFFKT QEDKEPISEN IEVSKELQIP ALSTRDNENQ CDYRTQNVLG LQKQITNMYP VQQNESKVNK KLRQKVNRKT EIISEVNHLD NDKSIEYTVK SHSLFLTQKD KEIIPGNLED PSEFETPALS TKDSGNLYDS EIQNVLGVKH GHDMQPACQN DSKIGKKPRL NVCQKSEIIP ETNQIYENDN KGVHDLEKDN FFSLTPKDKE TISENLQVTN EFQTVDLLIK DNGNLCDYDT QNILELKKYV TDRKSAEQNE SKINKLRNKV NWKTEIISEM NQIYEDNDKD AHVQESYTKD LDFKVNKSKQ KLECQDIINK HYMEVNSNEK ESCDQILDSY KVVKKRKKES SCKAKNILTK AKNKLASQLT ESSQTSISLE SDLKHITSEA DSDPGNPVEL CKTQKQSTTT LNKKDLPFVE EIKEGECQVK KVNKMTSKSK KRKTSIDPSP ESHEVMERIL DSVQGKSTVS EQADKENNLE NEKMVKNKPD FYTKAFRSLS EIHSPNIQDS SFDSVREGLV PLSVSSGKNV IIKENFALEC SPAFQVSDDE HEKMNKMKFK VNRRTQKSGI GDRPLQDLSN TSFVSNNTAE SENKSEDLSS ERTSRRRRCT PFYFKEPSLR DKMRR
Shugoshin-liki protein 2 (SGOL2) je jedan od dva sisarska ortologa iz Shugoshin/Mei-S322 porodice proteina koji regulišu sestrinsku hromatidnunu koheziju zaštitom integriteta multiproteinskog kompleksa nazvanog kohezin.[ 8] mitoza i mejoza , što je fizička osnova Mendelovog nasljeđa .
Svi testovi i analuitze su prema[ 11] [ 12]
|[ 13] [ 14] [ 15]
^ a b c GRCh38: Ensembl release 89: ENSG00000163535 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026039 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: SGOL2 shugoshin-like 2 (S. pombe)" .^ Kitajima TS; Kawashima SA; Watanabe Y (februar 2004). "The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis". Nature . 427 (6974): 510–7. Bibcode :2004Natur.427..510K . doi :10.1038/nature02312 . PMID 14730319 . S2CID 4400426 . ^ "UniProt, Q562F6" (jezik: engleski). Pristupljeno 19. 11. 2021 .^ Kitajima TS; Sakuno T; Ishiguro K; Iemura S; Natsume T; Kawashima SA; Watanabe Y (maj 2006). "Shugoshin collaborates with protein phosphatase 2A to protect cohesin". Nature . 441 (7089): 46–52. Bibcode :2006Natur.441...46K . doi :10.1038/nature04663 . PMID 16541025 . S2CID 4425074 . ^ "Salmonella infection data for Sgol2" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Sgol2" . Wellcome Trust Sanger Institute.^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 (S248). doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ Mouse Resources Portal , Wellcome Trust Sanger Institute.^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature 474 (7351): 337–342. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (juni 2011). "Mouse library set to be knockout" . Nature 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS; Rossant J; Wurst W (januar 2007). "A mouse for all reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 .
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