로67-4853번길
Ro67-4853 | |
| 식별자 | |
|---|---|
| |
| CAS 번호 | |
| 펍켐 CID | |
| IUPHAR/BPS | |
| 켐스파이더 | |
| CompTox 대시보드 (EPA) | |
| 화학 및 물리적 데이터 | |
| 공식 | C19H19NO4 |
| 어금질량 | 325.364 g·190−1 |
| 3D 모델(JSmol) | |
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| (iii) | |
Ro67-4853은 과학 연구에 사용되는 약물로, 메타보틱 글루타민산 수용체 하위형 mGluR에1 대한 선택적 양성 알로스테리 모듈레이터 역할을 한다.[1][2][3]그것은 더 단순한 화합물 Ro01-6128의 수정으로 파생되었고, 그 자체로 강력한 선택적 mGluR1 양성 변조기를 개발하기 위한 납 화합물로 사용되었다.[4][5]
참고 항목
참조
- ^ Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA (November 2001). "Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site". Proceedings of the National Academy of Sciences of the United States of America. 98 (23): 13402–7. Bibcode:2001PNAS...9813402K. doi:10.1073/pnas.231358298. PMC 60883. PMID 11606768.
- ^ Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ (August 2006). "A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators" (PDF). Molecular Pharmacology. 70 (2): 616–626. doi:10.1124/mol.105.021857. PMID 16645124. S2CID 2719603. Archived from the original (PDF) on 2019-02-22.
- ^ Sheffler DJ, Conn PJ (September 2008). "Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells". Neuropharmacology. 55 (4): 419–27. doi:10.1016/j.neuropharm.2008.06.047. PMC 2600811. PMID 18625258.
- ^ Vieira E, Huwyler J, Jolidon S, Knoflach F, Mutel V, Wichmann J (October 2005). "9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers". Bioorganic & Medicinal Chemistry Letters. 15 (20): 4628–31. doi:10.1016/j.bmcl.2005.05.135. PMID 16099654.
- ^ Vieira E, Huwyler J, Jolidon S, Knoflach F, Mutel V, Wichmann J (March 2009). "Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers". Bioorganic & Medicinal Chemistry Letters. 19 (6): 1666–9. doi:10.1016/j.bmcl.2009.01.108. PMID 19233648.
