호모사피엔스 종의 단백질 코딩 유전자
Kv 채널 상호작용 단백질 2 는 KCh 라고도 한다.IP2 는 인간에게 KCNIP2 유전자 에 의해 암호화된 단백질 이다.[5] [6]
함수 이 유전자는 EF핸드 슈퍼패밀리의 리페린 분기에 속하는 전압 게이트 칼륨(Kv ) 채널 상호작용 단백질(KCNIP, 흔히 "KCHIP"라고도 함) 계열의 한 부재를 암호화한 것이다.[7] KCNIP 계열의 구성원들은 작은 칼슘 결합 단백질이다. 이들은 모두 EF-핸드 방식의 도메인을 가지고 있으며, N-terminus 에서는 서로 다르다. 이들은 K4v 채널 단지의 필수 서브 유닛 구성품이다. 그들은 세포내 칼슘의 변화에 대응하여 A형 전류, 즉 뉴런의 흥분성을 조절할 수 있다. 대체 스플라이싱은 여러 개의 대본 변형이 서로 다른 ISO 양식을 인코딩하는 결과를 낳는다.[6]
참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000120049 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000025221 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature . 403 (6769): 553–6. doi :10.1038/35000592 . PMID 10676964 . S2CID 4419472 . ^ a b "Entrez Gene: KCNIP2 Kv channel interacting protein 2" .^ Burgoyne RD (Mar 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling" . Nature Reviews. Neuroscience . 8 (3): 182–93. doi :10.1038/nrn2093 . PMC 1887812 PMID 17311005 . 추가 읽기 Hartley JL, Temple GF, Brasch MA (Nov 2000). 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Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyêñ-Trân VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR, Chien KR (Dec 2001). "A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia" . Cell . 107 (6): 801–13. doi :10.1016/S0092-8674(01)00588-8 PMID 11747815 . S2CID 18389247 . Deschênes I, DiSilvestre D, Juang GJ, Wu RC, An WF, Tomaselli GF (Jul 2002). "Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?" . Circulation . 106 (4): 423–9. doi :10.1161/01.CIR.0000025417.65658.B6 PMID 12135940 . Deschênes I, Tomaselli GF (Sep 2002). "Modulation of Kv4.3 current by accessory subunits" . FEBS Letters . 528 (1–3): 183–8. doi :10.1016/S0014-5793(02)03296-9 PMID 12297301 . S2CID 41910930 . Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS (Sep 2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels" . The Journal of Biological Chemistry . 278 (38): 36445–54. doi :10.1074/jbc.M306142200 PMID 12829703 . Ren X, Shand SH, Takimoto K (Oct 2003). "Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide" . The Journal of Biological Chemistry . 278 (44): 43564–70. doi :10.1074/jbc.M302337200 PMID 12928444 . Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA (Feb 2004). "Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2" . The Journal of Biological Chemistry . 279 (7): 5549–54. doi :10.1074/jbc.M311332200 PMID 14623880 . Kim LA, Furst J, Gutierrez D, Butler MH, Xu S, Goldstein SA, Grigorieff N (Feb 2004). "Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution" . Neuron . 41 (4): 513–9. doi :10.1016/S0896-6273(04)00050-9 PMID 14980201 . S2CID 18151379 . Lin YL, Lin SR, Wu TT, Chang LS (Jul 2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochemical and Biophysical Research Communications . 319 (3): 720–4. doi :10.1016/j.bbrc.2004.05.064 . PMID 15184042 . Rhodes KJ, Carroll KI, Sung MA, Doliveira LC, Monaghan MM, Burke SL, Strassle BW, Buchwalder L, Menegola M, Cao J, An WF, Trimmer JS (Sep 2004). "KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain" . The Journal of Neuroscience . 24 (36): 7903–15. doi :10.1523/JNEUROSCI.0776-04.2004 PMC 6729940 PMID 15356203 . Lin YL, Chen CY, Cheng CP, Chang LS (Aug 2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochemical and Biophysical Research Communications . 321 (3): 606–10. doi :10.1016/j.bbrc.2004.07.006 . PMID 15358149 .
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