SLC23A2

SLC23A2
Identifiers
Aliases	SLC23A2 , NBTL1, SLC23A1, SVCT2, YSPL2, hSVCT2, solute carrier family 23 member 2
External IDs	OMIM: 603791 MGI: 1859682 HomoloGene: 68440 GeneCards: SLC23A2
Gene location (Human)
Chr.	Chromosome 20 (human)
End	5,010,293 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	131,987,028 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; cerebellar vermis; ; right lobe of liver; ; subthalamic nucleus; ; middle frontal gyrus; ; Brodmann area 46; ; retinal pigment epithelium; ; postcentral gyrus; ; frontal pole; ; spinal cord;
	Top expressed in
	secondary oocyte; ; entorhinal cortex; ; superior frontal gyrus; ; olfactory epithelium; ; right lung lobe; ; medial dorsal nucleus; ; medial geniculate nucleus; ; primary motor cortex; ; superior colliculus; ; cerebellar cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleobase transmembrane transporter activity ; transporter activity ; L-ascorbate:sodium symporter activity ; symporter activity ; L-ascorbic acid transmembrane transporter activity ; transmembrane transporter activity ;
Cellular component	cytoplasm ; membrane ; basal plasma membrane ; basolateral plasma membrane ; apical plasma membrane ; plasma membrane ; integral component of plasma membrane ; integral component of membrane ; contractile fiber ;
Biological process	sodium ion transport ; ion transport ; response to oxidative stress ; L-ascorbic acid transmembrane transport ; nucleobase transport ; transmembrane transport ; nucleobase-containing compound metabolic process ; L-ascorbic acid metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	9962
	54338
	ENSG00000089057
	ENSMUSG00000027340
	Q9UGH3
	Q9EPR4
	NM_005116 ; NM_203327
	NM_018824 ; NM_001355430 ; NM_001355431
	NP_005107 ; NP_976072
	NP_061294 ; NP_001342359 ; NP_001342360
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.^[5]^[6]^[7]

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.^[7]

Related Research Articles

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Solute carrier family 23 member 1 is a protein that in humans is encoded by the SLC23A1 gene.

Sodium- and chloride-dependent creatine transporter 1 is a protein that in humans is encoded by the SLC6A8 gene.

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Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.

Sodium-coupled neutral amino acid transporter 2 is a protein that in humans is encoded by the SLC38A2 gene.

Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene.

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.

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Solute carrier family 15, member 2, also known as SLC15A2, is a human gene.

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.

Sodium/hydrogen exchanger 8 is a protein that in humans is encoded by the SLC9A8 gene.

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.

Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene.

Solute carrier family 13 member 2 is a protein that is encoded in humans by the SLC13A2 gene.

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000089057 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027340 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (Dec 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochim Biophys Acta. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.
↑ Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (Jun 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. Bibcode:1999Natur.399...70T. doi:10.1038/19986. PMID 10331392. S2CID 4425479.
1 2 "Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2".

Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells". Mol. Membr. Biol. 18 (1): 87–95. doi: 10.1080/09687680110033774 . PMID 11396616. S2CID 22478598.
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID 9039502.
Hogue DL, Ling V (1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals". Genomics. 59 (1): 18–23. doi:10.1006/geno.1999.5847. PMID 10395795.
Rajan DP, Huang W, Dutta B, et al. (1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function". Biochem. Biophys. Res. Commun. 262 (3): 762–8. doi:10.1006/bbrc.1999.1272. PMID 10471399.
Daruwala R, Song J, Koh WS, et al. (1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2". FEBS Lett. 460 (3): 480–4. doi: 10.1016/S0014-5793(99)01393-9 . PMID 10556521. S2CID 37936975.
Breton S, Wiederhold T, Marshansky V, et al. (2000). "The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells". J. Biol. Chem. 275 (24): 18219–24. doi: 10.1074/jbc.M909857199 . PMID 10748165.
Holliday LS, Lu M, Lee BS, et al. (2000). "The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site". J. Biol. Chem. 275 (41): 32331–7. doi: 10.1074/jbc.M004795200 . PMID 10915794.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.
Hediger MA (2002). "New view at C.". Nat. Med. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID 11984580. S2CID 787845.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Fischer H, Schwarzer C, Illek B (2004). "Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3691–6. Bibcode:2004PNAS..101.3691F. doi: 10.1073/pnas.0308393100 . PMC 373524 . PMID 14993613.
Lutsenko EA, Carcamo JM, Golde DW (2004). "A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport". Mol. Cell. Biol. 24 (8): 3150–6. doi:10.1128/MCB.24.8.3150-3156.2004. PMC 381605 . PMID 15060139.
Seno T, Inoue N, Matsui K, et al. (2004). "Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells". J. Vasc. Res. 41 (4): 345–51. doi:10.1159/000080525. PMID 15340249. S2CID 20754421.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
McNulty AL, Vail TP, Kraus VB (2005). "Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2". Biochim. Biophys. Acta. 1712 (2): 212–21. doi:10.1016/j.bbamem.2005.04.009. PMID 15921655.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000089057 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027340 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9804989-5] Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (Dec 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochim Biophys Acta. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.

[pmid10331392-6] Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (Jun 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. Bibcode:1999Natur.399...70T. doi:10.1038/19986. PMID 10331392. S2CID 4425479.

[entrez-7] 1 2 "Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2".

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SLC23A2

Contents

See also

Related Research Articles

References

Further reading