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The age-1 gene is located on chromosome 2 in C.elegans. It gained attention in 1983 for its ability to induce long-lived C. elegans mutants. The age-1 mutant, first identified by Michael Klass, was reported to extend mean lifespan by over 50% at 25 °C when compared to the wild type worm (N2) in 1987 by Johnson et al. Development, metabolism, lifespan, among other processes have been associated with age-1 expression. The age-1 gene is known to share a genetic pathway with daf-2 gene that regulates lifespan in worms. Additionally, both age-1 and daf-2 mutants are dependent on daf-16 and daf-18 genes to promote lifespan extension.
References
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- ↑ Gami MS, Wolkow CA (February 2006). "Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan". Aging Cell. 5 (1): 31–7. doi:10.1111/j.1474-9726.2006.00188.x. PMC 1413578 . PMID 16441841.
- ↑ Dorman JB, Albinder B, Shroyer T, Kenyon C (December 1995). "The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans". Genetics. 141 (4): 1399–1406. doi:10.1093/genetics/141.4.1399. PMC 1206875 . PMID 8601482.
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- ↑ Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G (August 1997). "daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans". Science. 277 (5328): 942–6. doi:10.1126/science.277.5328.942. PMID 9252323.
- ↑ Kenyon C (February 2005). "The plasticity of aging: insights from long-lived mutants". Cell. 120 (4): 449–60. doi: 10.1016/j.cell.2005.02.002 . PMID 15734678.
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- ↑ Lee SJ, Murphy CT, Kenyon C (November 2009). "Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression". Cell Metabolism. 10 (5): 379–91. doi:10.1016/j.cmet.2009.10.003. PMC 2887095 . PMID 19883616.