Koštani morfogenetički protein

Koštani mofogenetički proteini (BMP) grupa su faktora rasta. Oni su takođe poznati kao citokini i metabologeni.^[1] Originalno otkriveni po njihovoj sposobnosti da indukuju formiranje kostiju i hrskavice, BMP proteini se smatraju konstitutivnom grupom ključnih morfogenenih signala koji orkestruju arhitekturu tkiva širom tela.^[2] Na važnost dejstva BMP signala u fiziologiji ukazuje mnoštvo njihovih uloga u disregulaciji BMP signalizacije u patološkim procesima. Misregulacija BMP signalnog sistema se često javlja kod kancerogenih bolesti. Odsustvo BMP signalizacije je, na primer, važan faktor u progresiji raka debelog creva,^[3] i nasuprot tome, prekomerna aktivacija BMP signalizacije nakon refluksom indukovanog ezofagitisa uzrokuje Baretov ezofagitis, i stoga dovodi do razvića adenokarcinoma u proksimalnom delu gastrointestinalnog trakta.^[4]

Rekombinantni humani BMP proteini imaju ortopedijske primene, na primer u spinalnim fuzijama i oralnoj hirurgiji.

Reference

^ Reddi, AH; Reddi, A (2009). „Bone morphogenetic proteins (BMPs): from morphogens to metabologens”. Cytokine & growth factor reviews. 20 (5-6): 341—2. PMID 19900831. doi:10.1016/j.cytogfr.2009.10.015.
^ Bleuming SA, He XC, Kodach LL, Hardwick JC, Koopman FA, Ten Kate FJ, van Deventer SJ, Hommes DW, Peppelenbosch MP, Offerhaus GJ, Li L, van den Brink GR (2007). „Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice.”. Cancer Research. 67 (17): 8149—55. PMID 17804727. doi:10.1158/0008-5472.CAN-06-4659.
^ Kodach LL, Wiercinska E, de Miranda NF, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, van Noesel CJ, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJ, Hardwick JC (2008). „The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.”. Gastroenterology. 134 (5): 1332—41. PMID 18471510. doi:10.1053/j.gastro.2008.02.059.
^ Milano F, van Baal JW, Buttar NS, Rygiel AM, de Kort F, DeMars CJ, Rosmolen WD, Bergman JJ, Van Marle J, Wang KK, Peppelenbosch MP, Krishnadath KK (2007). „Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells.”. Gastroeneterology. 132 (7): 2412—21. PMID 17570215. doi:10.1053/j.gastro.2007.03.026.

Literatura

Chen, Di, Zhao, Ming, and Mundy, Gregory R. (2004). „Bone Morphogenetic Proteins”. Growth Factors. 22 (4): 233—241. PMID 15621726. doi:10.1080/08977190412331279890.
Cheng H, Jiang W, Phillips F, Haydon R, Peng Y, Zhou L, Luu H, An N, Breyer B, Vanichakarn P, Szatkowski J, Park J, He T (2003). „Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)”. J Bone Joint Surg Am. 85—A (8): 1544—52. PMID 12925636. link

Spoljašnje veze

Bone+Morphogenetic+Proteins на US National Library of Medicine Medical Subject Headings (MeSH)
BMP: The What and the Who
BMPedia - the Bone Morphogenetic Protein Wiki

[1] Reddi, AH; Reddi, A (2009). „Bone morphogenetic proteins (BMPs): from morphogens to metabologens”. Cytokine & growth factor reviews. 20 (5-6): 341—2. PMID 19900831. doi:10.1016/j.cytogfr.2009.10.015.

[2] Bleuming SA, He XC, Kodach LL, Hardwick JC, Koopman FA, Ten Kate FJ, van Deventer SJ, Hommes DW, Peppelenbosch MP, Offerhaus GJ, Li L, van den Brink GR (2007). „Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice.”. Cancer Research. 67 (17): 8149—55. PMID 17804727. doi:10.1158/0008-5472.CAN-06-4659.

[3] Kodach LL, Wiercinska E, de Miranda NF, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, van Noesel CJ, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJ, Hardwick JC (2008). „The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.”. Gastroenterology. 134 (5): 1332—41. PMID 18471510. doi:10.1053/j.gastro.2008.02.059.

[4] Milano F, van Baal JW, Buttar NS, Rygiel AM, de Kort F, DeMars CJ, Rosmolen WD, Bergman JJ, Van Marle J, Wang KK, Peppelenbosch MP, Krishnadath KK (2007). „Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells.”. Gastroeneterology. 132 (7): 2412—21. PMID 17570215. doi:10.1053/j.gastro.2007.03.026.

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