JNJ 7777120

JNJ 7777120
IUPAC ime
	5-hloro-2-[(4-metilpiperazin-1-il)karbonil]-1H-indol
Identifikatori
CAS broj	459168-41-3
ATC kod	none
PubChem	CID 4908365
IUPHAR/BPS	1278
ChEMBL	CHEMBL129198
Sinonimi	1-[(5-hloro-1H-indol-2-il)karbonil]-4-metilpiperazin
Hemijski podaci
Formula	C14H16ClN3O
Molarna masa	277,749 g/mol
	SMILES C3CN(C)CCN3C(=O)c(cc1c2)nc1ccc2Cl; ;

JNJ-7777120 je lek koji je razvila kompanija Džonson & Džonson. On deluje kao potentan i selektivan antagonist histaminskog H4 receptora.^[1] On ima antiinflamatorno dejstvo.^[2] Pokazano je da je superioran u odnosu na traditionalne antihistamine u treatmanu pruritusa (svraba).^[3]

Reference

^ Jiang W; Lim, HD; Zhang M; et al. (2008). „Cloning and pharmacological characterization of the dog histamine H(4) receptor”. Eur. J. Pharmacol. 592 (1–3): 26—32. PMID 18639542. doi:10.1016/j.ejphar.2008.06.095.
^ Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. Journal of Pharmacology and Experimental Therapeutics. 2004 Apr;309(1):404-13. PMID 14722321
^ Dunford PJ, Williams KN, Desai PJ, Karlsson L, McQueen D, Thurmond RL. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. Journal of Allergy and Clinical Immunology. 2007 Jan;119(1):176-83. PMID 17208599