GNAI2

Guanin nukleotid-vezujući protein (G protein), alfa inhibirajući polipeptid 2
Guanin nukleotid-vezujući protein (G protein), alfa inhibirajući polipeptid 2
Identifikatori
Simboli	GNAI2; GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1
Vanjski ID	OMIM: 139360 MGI: 95772 HomoloGene: 55539 GeneCards: GNAI2 Gene
Ontologija gena
Molekularna funkcija	• vezivanje nukleotida; • aktivnost GTPaze; • aktivnost prenosnika signala; • vezivanje proteina; • GTP vezivanje; • vezivanje guanil nukleotida;
Celularna komponenta	• heterotrimerni G-proteinski kompleks; • membrana plazme;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora; • G-protein signalizacija, put inhibicije adenilat ciklaze; • negativna regulacija aktivnosti adenilat ciklaze; • acetilholin receptorska signalizacija, muskarinski put; • respons na nutrijent; • ćelijska proliferacija;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	2771
Ensembl	ENSG00000114353
UniProt	P04899
RefSeq (mRNA)	NM_002070
RefSeq (protein)	NP_002061
Lokacija (UCSC)	Chr 3:; 50.24 - 50.27 Mb
PubMed pretraga	[1]

GNAI2, Guanin nukleotid-vezujući protein G(i), alfa-2 podjedinica, je protein koji je kod ljudi kodiran GNAI2 genom.^[1]^[2]^[3]

Interakcije

Za GNAI2 je bilo pokazano da formira interakcije sa GPSM2,^[4]^[5] RIC8A,^[6] Interleukin 8 receptor, alpha,^[7]^[8] EYA2,^[9] RGS5^[10]^[11] i MDFI.^[12]

Reference

^ Didsbury JR, Ho YS, Snyderman R (1987). „Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA”. FEBS Lett. 211 (2): 160—4. PMID 3100330. doi:10.1016/0014-5793(87)81428-X.
^ Magovcevic I, Ang SL, Seidman JG, Tolman CJ, Neer EJ, Morton CC (1992). „Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13”. Genomics. 12 (1): 125—9. PMID 1733849. doi:10.1016/0888-7543(92)90414-N.
^ „Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2”.
^ Marty, Caroline; Browning Darren D; Ye Richard D (2003). „Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras”. Mol. Cell. Biol. United States. 23 (11): 3847—58. ISSN 0270-7306. PMC 155206 . PMID 12748287. doi:10.1128/MCB.23.11.3847-3858.2003.
^ Mochizuki, N; Cho G; et al. (1996). „Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2”. Gene. NETHERLANDS. 181 (1-2): 39—43. ISSN 0378-1119. PMID 8973305. doi:10.1016/S0378-1119(96)00456-8.
^ Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200.
^ Damaj, B B; McColl S R; et al. (1996). „Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops”. FASEB J. UNITED STATES. 10 (12): 1426—34. ISSN 0892-6638. PMID 8903513.
^ Damaj, B B; McColl S R; et al. (1996). „Physical association of Gi2alpha with interleukin-8 receptors”. J. Biol. Chem. UNITED STATES. 271 (22): 12783—9. ISSN 0021-9258. PMID 8662698. doi:10.1074/jbc.271.22.12783.
^ Fan, X; Brass L F; et al. (2000). „The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins”. J. Biol. Chem. UNITED STATES. 275 (41): 32129—34. ISSN 0021-9258. PMID 10906137. doi:10.1074/jbc.M004577200.
^ Chen, C; Zheng B; et al. (1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. J. Biol. Chem. UNITED STATES. 272 (13): 8679—85. ISSN 0021-9258. PMID 9079700. doi:10.1074/jbc.272.13.8679.
^ Zhou, J; Moroi K; et al. (2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sci. England. 68 (13): 1457—69. ISSN 0024-3205. PMID 11253162. doi:10.1016/S0024-3205(01)00939-0.
^ Rual, Jean-François; Venkatesan Kavitha; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. England. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.

Literatura

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Offermanns S, Schultz G, Rosenthal W (1991). „Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells.”. J. Biol. Chem. 266 (6): 3365—8. PMID 1671672.
Cormont M; Le Marchand-Brustel Y; Van Obberghen E; et al. (1991). „Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor.”. Diabetes. 40 (9): 1170—6. PMID 1718802. doi:10.2337/diabetes.40.9.1170.
Bushfield M; Murphy GJ; Lavan BE; et al. (1990). „Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes.”. Biochem. J. 268 (2): 449—57. PMC 1131453 . PMID 2114093.
Lyons J; Landis CA; Harsh G; et al. (1990). „Two G protein oncogenes in human endocrine tumors.”. Science. 249 (4969): 655—9. PMID 2116665. doi:10.1126/science.2116665.
Osawa S, Dhanasekaran N, Woon CW, Johnson GL (1990). „G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions.”. Cell. 63 (4): 697—706. PMID 2121366.
McClue SJ, Milligan G (1990). „The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2.”. FEBS Lett. 269 (2): 430—4. PMID 2169434. doi:10.1016/0014-5793(90)81209-7.
Rudolph U; Koesling D; Hinsch KD; et al. (1989). „G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils.”. Mol. Cell. Endocrinol. 63 (1-2): 143—53. PMID 2502457. doi:10.1016/0303-7207(89)90090-7.
Lang JC, Costa T (1990). „Distribution of the alpha-subunit of the guanine nucleotide-binding protein Gi2 and its comparison to G alpha o.”. J. Recept. Res. 9 (4-5): 313—29. PMID 2512386.
Itoh H; Toyama R; Kozasa T; et al. (1988). „Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.”. J. Biol. Chem. 263 (14): 6656—64. PMID 2834384.
Weinstein LS, Spiegel AM, Carter AD (1988). „Cloning and characterization of the human gene for the alpha-subunit of Gi2, a GTP-binding signal transduction protein.”. FEBS Lett. 232 (2): 333—40. PMID 2837412. doi:10.1016/0014-5793(88)80764-6.
Beals CR, Wilson CB, Perlmutter RM (1987). „A small multigene family encodes Gi signal-transduction proteins.”. Proc. Natl. Acad. Sci. U.S.A. 84 (22): 7886—90. PMC 299440 . PMID 3120178. doi:10.1073/pnas.84.22.7886.
Williamson EA; Ince PG; Harrison D; et al. (1995). „G-protein mutations in human pituitary adrenocorticotrophic hormone-secreting adenomas.”. Eur. J. Clin. Invest. 25 (2): 128—31. PMID 7737262. doi:10.1111/j.1365-2362.1995.tb01537.x.
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Grassie MA, Milligan G (1995). „Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts.”. Biochem. J. 306 (Pt 2): 525—30. PMC 1136549 . PMID 7887906.
Migeon JC, Thomas SL, Nathanson NM (1994). „Regulation of cAMP-mediated gene transcription by wild type and mutated G-protein alpha subunits. Inhibition of adenylyl cyclase activity by muscarinic receptor-activated and constitutively activated G(o) alpha.”. J. Biol. Chem. 269 (46): 29146—52. PMID 7961880.
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[pmid3100330-1] Didsbury JR, Ho YS, Snyderman R (1987). „Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA”. FEBS Lett. 211 (2): 160—4. PMID 3100330. doi:10.1016/0014-5793(87)81428-X.

[pmid1733849-2] Magovcevic I, Ang SL, Seidman JG, Tolman CJ, Neer EJ, Morton CC (1992). „Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13”. Genomics. 12 (1): 125—9. PMID 1733849. doi:10.1016/0888-7543(92)90414-N.

[3] „Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2”.

[pmid12748287-4] Marty, Caroline; Browning Darren D; Ye Richard D (2003). „Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras”. Mol. Cell. Biol. United States. 23 (11): 3847—58. ISSN 0270-7306. PMC 155206 . PMID 12748287. doi:10.1128/MCB.23.11.3847-3858.2003.

[pmid8973305-5] Mochizuki, N; Cho G; et al. (1996). „Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2”. Gene. NETHERLANDS. 181 (1-2): 39—43. ISSN 0378-1119. PMID 8973305. doi:10.1016/S0378-1119(96)00456-8.

[pmid12509430-6] Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200.

[pmid8903513-7] Damaj, B B; McColl S R; et al. (1996). „Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops”. FASEB J. UNITED STATES. 10 (12): 1426—34. ISSN 0892-6638. PMID 8903513.

[pmid8662698-8] Damaj, B B; McColl S R; et al. (1996). „Physical association of Gi2alpha with interleukin-8 receptors”. J. Biol. Chem. UNITED STATES. 271 (22): 12783—9. ISSN 0021-9258. PMID 8662698. doi:10.1074/jbc.271.22.12783.

[pmid10906137-9] Fan, X; Brass L F; et al. (2000). „The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins”. J. Biol. Chem. UNITED STATES. 275 (41): 32129—34. ISSN 0021-9258. PMID 10906137. doi:10.1074/jbc.M004577200.

[pmid9079700-10] Chen, C; Zheng B; et al. (1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. J. Biol. Chem. UNITED STATES. 272 (13): 8679—85. ISSN 0021-9258. PMID 9079700. doi:10.1074/jbc.272.13.8679.

[pmid11253162-11] Zhou, J; Moroi K; et al. (2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sci. England. 68 (13): 1457—69. ISSN 0024-3205. PMID 11253162. doi:10.1016/S0024-3205(01)00939-0.

[pmid16189514-12] Rual, Jean-François; Venkatesan Kavitha; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. England. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.

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