MX2017015299A - Dinucleotidos de purina ciclica como moduladores del estimulador de los genes de interferon. - Google Patents

Dinucleotidos de purina ciclica como moduladores del estimulador de los genes de interferon.

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Publication number
MX2017015299A
MX2017015299A MX2017015299A MX2017015299A MX2017015299A MX 2017015299 A MX2017015299 A MX 2017015299A MX 2017015299 A MX2017015299 A MX 2017015299A MX 2017015299 A MX2017015299 A MX 2017015299A MX 2017015299 A MX2017015299 A MX 2017015299A
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MX
Mexico
Prior art keywords
sting
modulators
cyclic purine
purine dinucleotides
diseases
Prior art date
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MX2017015299A
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English (en)
Other versions
MX363780B (es
Inventor
Jerry Leroy Adams
Kevin J Duffy
Lian Yiqian
Original Assignee
Glaxosmithkline Ip Dev Ltd
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Publication of MX2017015299A publication Critical patent/MX2017015299A/es
Publication of MX363780B publication Critical patent/MX363780B/es

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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65746—Esters of oxyacids of phosphorus the molecule containing more than one cyclic phosphorus atom
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto de fórmula (I) (ver Fórmula) en donde Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8 y R9 son como se define en la presente; y sales y tautómeros farmacéuticamente aceptables de estos, composiciones, combinaciones y medicamentos que contienen dichos compuestos y procesos para su preparación; la invención también se refiere al uso de dichos compuestos, combinaciones, composiciones y medicamentos en el tratamiento de enfermedades en las cuales la modulación de STING (estimulador de los genes de interferón) es beneficiosa, por ejemplo inflamación, enfermedades alérgicas y autoinmunes, enfermedades infecciosas, cáncer, síndromes precancerosos y como adyuvantes de vacunas.
MX2017015299A 2015-12-03 2016-12-01 Dinucleótidos de purina cíclica como moduladores del estimulador de los genes de interferón. MX363780B (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562262668P 2015-12-03 2015-12-03
US201662299253P 2016-02-24 2016-02-24
US201662299704P 2016-02-25 2016-02-25
US201662327579P 2016-04-26 2016-04-26
US201662332517P 2016-05-06 2016-05-06
PCT/IB2016/057265 WO2017093933A1 (en) 2015-12-03 2016-12-01 Cyclic purine dinucleotides as modulators of sting

Publications (2)

Publication Number Publication Date
MX2017015299A true MX2017015299A (es) 2018-03-15
MX363780B MX363780B (es) 2019-04-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017015299A MX363780B (es) 2015-12-03 2016-12-01 Dinucleótidos de purina cíclica como moduladores del estimulador de los genes de interferón.

Country Status (23)

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US (4) US9718848B2 (es)
EP (2) EP3366691A1 (es)
JP (1) JP6411676B2 (es)
KR (1) KR101949108B1 (es)
CN (1) CN107849084B (es)
AU (1) AU2016362697B2 (es)
CA (1) CA3006930A1 (es)
CL (1) CL2018001484A1 (es)
CO (1) CO2017013310A2 (es)
CR (1) CR20180286A (es)
ES (1) ES2863225T3 (es)
HK (1) HK1250032A1 (es)
IL (1) IL255525B (es)
MA (1) MA52157A (es)
MX (1) MX363780B (es)
NZ (1) NZ738202A (es)
PE (1) PE20181297A1 (es)
PH (1) PH12017502332A1 (es)
RU (2) RU2020113165A (es)
TW (1) TWI704154B (es)
UY (1) UY37007A (es)
WO (1) WO2017093933A1 (es)
ZA (1) ZA201801631B (es)

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