CR20190168A - Compuestos de benzo[b]tiofeno como agonistas de sting - Google Patents
Compuestos de benzo[b]tiofeno como agonistas de stingInfo
- Publication number
- CR20190168A CR20190168A CR20190168A CR20190168A CR20190168A CR 20190168 A CR20190168 A CR 20190168A CR 20190168 A CR20190168 A CR 20190168A CR 20190168 A CR20190168 A CR 20190168A CR 20190168 A CR20190168 A CR 20190168A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds
- general
- general formula
- fórmula
- los compuestos
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662404062P | 2016-10-04 | 2016-10-04 | |
| PCT/US2017/054688 WO2018067423A1 (en) | 2016-10-04 | 2017-10-02 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20190168A true CR20190168A (es) | 2019-05-17 |
Family
ID=60084122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20190168A CR20190168A (es) | 2016-10-04 | 2017-10-02 | Compuestos de benzo[b]tiofeno como agonistas de sting |
Country Status (39)
| Country | Link |
|---|---|
| US (3) | US10414747B2 (es) |
| EP (1) | EP3523287B1 (es) |
| JP (1) | JP6636673B2 (es) |
| KR (1) | KR102312721B1 (es) |
| CN (1) | CN110036001B (es) |
| AR (1) | AR109788A1 (es) |
| AU (1) | AU2017339418C1 (es) |
| CA (1) | CA3038903C (es) |
| CL (1) | CL2019000902A1 (es) |
| CO (1) | CO2019003349A2 (es) |
| CR (1) | CR20190168A (es) |
| CY (1) | CY1124837T1 (es) |
| DK (1) | DK3523287T3 (es) |
| DO (1) | DOP2019000083A (es) |
| EA (1) | EA037626B1 (es) |
| EC (1) | ECSP19026680A (es) |
| ES (1) | ES2893532T3 (es) |
| GE (1) | GEP20217285B (es) |
| HR (1) | HRP20211617T1 (es) |
| HU (1) | HUE056502T2 (es) |
| IL (1) | IL265678B2 (es) |
| JO (1) | JOP20190070B1 (es) |
| LT (1) | LT3523287T (es) |
| MA (1) | MA46452B1 (es) |
| MD (1) | MD3523287T2 (es) |
| MX (1) | MX2019003829A (es) |
| MY (1) | MY196383A (es) |
| NI (1) | NI201900029A (es) |
| PE (1) | PE20190705A1 (es) |
| PH (1) | PH12019500712A1 (es) |
| PL (1) | PL3523287T3 (es) |
| PT (1) | PT3523287T (es) |
| RS (1) | RS62410B1 (es) |
| SG (1) | SG10202008647TA (es) |
| SI (1) | SI3523287T1 (es) |
| TN (2) | TN2020000159A1 (es) |
| TW (1) | TWI796306B (es) |
| UA (1) | UA125223C2 (es) |
| WO (1) | WO2018067423A1 (es) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017233068C1 (en) | 2016-03-18 | 2023-05-25 | Immune Sensor, Llc | Cyclic di-nucleotide compounds and methods of use |
| JP7100227B2 (ja) | 2016-07-06 | 2022-07-13 | エフ－スター・セラピューティクス・インコーポレイテッド | 疾患の治療のための化合物、組成物、および方法 |
| CR20190168A (es) * | 2016-10-04 | 2019-05-17 | Merck Sharp & Dohme | Compuestos de benzo[b]tiofeno como agonistas de sting |
| PE20191353A1 (es) | 2016-10-14 | 2019-10-01 | Prec Biosciences Inc | Meganucleasas disenadas especificamente para el reconocimiento de secuencias en el genoma del virus de la hepatitis b |
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| EP3609922A2 (en) | 2017-04-13 | 2020-02-19 | Aduro Biotech Holdings, Europe B.V. | Anti-sirp alpha antibodies |
| MA49773A (fr) | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme | Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[b |
| EP3661498A4 (en) * | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme Corp. | BENZO [B] THIOPHEN STING ANTAGONISTS FOR CANCER TREATMENT |
| CA3074232A1 (en) | 2017-08-31 | 2019-03-07 | Sperovie Biosciences, Inc. | Compounds, compositions, and methods for the treatment of disease |
| US11584774B2 (en) | 2017-09-11 | 2023-02-21 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| US11707531B2 (en) | 2017-09-11 | 2023-07-25 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| CN111194214A (zh) * | 2017-10-05 | 2020-05-22 | 葛兰素史密斯克莱知识产权发展有限公司 | 施用sting激动剂的方法 |
| CN111566119A (zh) | 2017-11-10 | 2020-08-21 | 武田药品工业有限公司 | Sting调节剂化合物以及制备和使用方法 |
| CN111433361B (zh) | 2017-12-01 | 2024-03-29 | 德克萨斯A&M大学体系 | 天使综合征反义治疗 |
| KR102492187B1 (ko) | 2017-12-20 | 2023-01-27 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | Sting 어댑터 단백질을 활성화하는 포스포네이트 결합을 가진 3'3' 사이클릭 다이뉴클레오티드 |
| KR102492115B1 (ko) | 2017-12-20 | 2023-01-27 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | Sting 어댑터 단백질을 활성화하는 포스포네이트 결합을 가진 2'3' 사이클릭 다이뉴클레오티드 |
| AU2019223182B2 (en) | 2018-02-26 | 2021-08-19 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds as HBV replication inhibitors |
| TWI793294B (zh) * | 2018-04-03 | 2023-02-21 | 美商默沙東有限責任公司 | Sting促效劑化合物 |
| WO2019195063A1 (en) * | 2018-04-03 | 2019-10-10 | Merck Sharp & Dohme Corp. | Aza-benzothiophene compounds as sting agonists |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TW201945388A (zh) | 2018-04-12 | 2019-12-01 | 美商精密生物科學公司 | 對b型肝炎病毒基因體中之識別序列具有特異性之最佳化之經工程化巨核酸酶 |
| US20190359645A1 (en) | 2018-05-03 | 2019-11-28 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| WO2019227007A1 (en) | 2018-05-25 | 2019-11-28 | Incyte Corporation | Tricyclic heterocyclic compounds as sting activators |
| WO2020010451A1 (en) * | 2018-07-10 | 2020-01-16 | Trillium Therapeutics Inc. | Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists |
| CA3107660A1 (en) * | 2018-07-26 | 2020-01-30 | Bristol-Myers Squibb Company | Lag-3 combination therapy for the treatment of cancer |
| WO2020028565A1 (en) | 2018-07-31 | 2020-02-06 | Incyte Corporation | Tricyclic heteraryl compounds as sting activators |
| US10875872B2 (en) | 2018-07-31 | 2020-12-29 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| KR102567591B1 (ko) | 2018-09-06 | 2023-08-16 | 다이이찌 산쿄 가부시키가이샤 | 신규 고리형 디뉴클레오티드 유도체 및 그 항체 약물 콘쥬게이트 |
| SG11202103573YA (en) | 2018-10-11 | 2021-05-28 | Ono Pharmaceutical Co | STING Agonistic Compound |
| KR102650496B1 (ko) | 2018-10-31 | 2024-03-26 | 길리애드 사이언시즈, 인코포레이티드 | Hpk1 억제제로서의 치환된 6-아자벤즈이미다졸 화합물 |
| US11071730B2 (en) | 2018-10-31 | 2021-07-27 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| US11596692B1 (en) | 2018-11-21 | 2023-03-07 | Incyte Corporation | PD-L1/STING conjugates and methods of use |
| CN111393404B (zh) * | 2019-01-02 | 2023-02-17 | 中国科学院上海药物研究所 | 一类苯并噻吩类化合物及其药物组合物及应用 |
| CN111393405B (zh) | 2019-01-02 | 2022-11-25 | 中国科学院上海药物研究所 | 一类含氟取代的苯并噻吩类化合物及其药物组合物及应用 |
| US12129267B2 (en) | 2019-01-07 | 2024-10-29 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| WO2020165600A1 (en) | 2019-02-14 | 2020-08-20 | Bicycletx Limited | Bicyclic peptide ligand sting conjugates and uses thereof |
| KR20210137518A (ko) | 2019-03-07 | 2021-11-17 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | 3'3'-사이클릭 다이뉴클레오티드 및 이의 프로드럭 |
| US11766447B2 (en) | 2019-03-07 | 2023-09-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| WO2020178769A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| CN111848573B (zh) * | 2019-04-30 | 2023-04-07 | 四川科伦博泰生物医药股份有限公司 | 苯并噻吩酰胺类化合物及其制备方法和用途 |
| WO2020221038A1 (zh) | 2019-04-30 | 2020-11-05 | 四川科伦博泰生物医药股份有限公司 | 苯并噻吩类化合物及其制备方法和用途 |
| CN111848572B (zh) * | 2019-04-30 | 2023-03-31 | 四川科伦博泰生物医药股份有限公司 | 酰胺类化合物及其制备方法和用途 |
| WO2020227159A2 (en) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity |
| WO2020237025A1 (en) | 2019-05-23 | 2020-11-26 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| PE20220231A1 (es) | 2019-06-25 | 2022-02-07 | Gilead Sciences Inc | Proteinas de fusion flt3l-fc y metodos de uso |
| CA3145889A1 (en) | 2019-07-05 | 2021-01-14 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| US11155567B2 (en) | 2019-08-02 | 2021-10-26 | Mersana Therapeutics, Inc. | Sting agonist compounds and methods of use |
| WO2021034804A1 (en) | 2019-08-19 | 2021-02-25 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| MX2022002152A (es) * | 2019-08-21 | 2022-05-18 | Scripps Research Inst | Agonistas biciclicos del estimulador de genes de interferon sting. |
| US20220288065A1 (en) * | 2019-08-21 | 2022-09-15 | The Scripps Research Institute | Monocyclic agonists of stimulator of interferon genes sting |
| PE20221111A1 (es) | 2019-09-30 | 2022-07-11 | Gilead Sciences Inc | Vacunas para vhb y metodos de tratamiento de vhb |
| KR20220100607A (ko) * | 2019-10-28 | 2022-07-15 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | 5원 헤테로사이클릭 옥소카르복실산 화합물 및 이의 의약 용도 |
| WO2021113679A1 (en) * | 2019-12-06 | 2021-06-10 | Mersana Therapeutics, Inc. | Dimeric compounds as sting agonists |
| CN116057068A (zh) | 2019-12-06 | 2023-05-02 | 精密生物科学公司 | 对乙型肝炎病毒基因组中的识别序列具有特异性的优化的工程化大范围核酸酶 |
| EP4115909A4 (en) | 2020-03-06 | 2024-10-30 | Daiichi Sankyo Co Ltd | ANTIBODY-DRUG CONJUGATE COMPRISING A NOVEL CYCLIC DINUCLEOTIDE DERIVATIVE |
| US11718637B2 (en) | 2020-03-20 | 2023-08-08 | Gilead Sciences, Inc. | Prodrugs of 4′-C-substituted-2-halo-2′- deoxyadenosine nucleosides and methods of making and using the same |
| EP4134134A4 (en) | 2020-04-10 | 2023-12-27 | ONO Pharmaceutical Co., Ltd. | STING AGONIST COMPOUND |
| JPWO2021206158A1 (es) | 2020-04-10 | 2021-10-14 | ||
| JP2023526250A (ja) | 2020-05-13 | 2023-06-21 | マサチューセッツ インスティテュート オブ テクノロジー | ポリマーマイクロデバイスの組成物およびがん免疫療法におけるその使用 |
| CN113861161A (zh) * | 2020-06-30 | 2021-12-31 | 上海海和药物研究开发股份有限公司 | 一种芳基并芳杂环衍生物及其制备方法和用途 |
| US20230256109A1 (en) | 2020-08-07 | 2023-08-17 | Tambo, Inc. | Trans-Cyclooctene Bioorthogonal Agents and Uses in Cancer and Immunotherapy |
| US20230303599A1 (en) | 2020-08-07 | 2023-09-28 | Gilead Sciences, Inc. | Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use |
| US20240336907A1 (en) | 2020-09-02 | 2024-10-10 | Daiichi Sankyo Company, Limited | NOVEL ENDO-ß-N-ACETYLGLUCOSAMINIDASE |
| KR20230106606A (ko) | 2020-11-09 | 2023-07-13 | 다케다 야쿠힌 고교 가부시키가이샤 | 항체 약물 접합체 |
| CN113429384B (zh) * | 2021-05-12 | 2022-04-08 | 中山大学附属第五医院 | 一类干扰素基因刺激因子靶向的放射性pet显像剂 |
| TW202310852A (zh) | 2021-05-13 | 2023-03-16 | 美商基利科學股份有限公司 | ＴＬＲ８調節化合物及抗ＨＢＶ ｓｉＲＮＡ療法之組合 |
| US20220389394A1 (en) | 2021-05-18 | 2022-12-08 | Gilead Sciences, Inc. | METHODS OF USING FLT3L-Fc FUSION PROTEINS |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| EP4359389A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| EP4359415A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CN117377671A (zh) | 2021-06-23 | 2024-01-09 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| CN117836007A (zh) * | 2021-07-13 | 2024-04-05 | 南京大学 | 一种pt偶联物及其用途 |
| CN113429387B (zh) * | 2021-07-27 | 2022-10-28 | 中国药科大学 | 一种苯并[b]硒吩类STING调控剂、其制备方法及用途 |
| CN115772154B (zh) * | 2021-09-08 | 2024-04-30 | 上海交通大学 | 一类含有氘取代的苯并噻吩类衍生物及其制备与用途 |
| WO2023167238A1 (ja) | 2022-03-02 | 2023-09-07 | 第一三共株式会社 | Ｆｃ含有分子の製造方法 |
| WO2023211940A1 (en) * | 2022-04-25 | 2023-11-02 | The Regents Of The University Of Michigan | Sting agonists, formulations, and uses thereof |
| AU2023263297A1 (en) * | 2022-04-25 | 2024-11-14 | The Regents Of The University Of Michigan | Dual functioning immune modulating compounds, formulations, and uses thereof |
| WO2024175086A1 (zh) * | 2023-02-24 | 2024-08-29 | 深圳真实生物医药科技有限公司 | 芳基三并环类sting激动剂及其用途 |
| CN116354922A (zh) * | 2023-03-31 | 2023-06-30 | 药康众拓(江苏)医药科技有限公司 | 氘代苯并噻吩类化合物及其药物组合物和用途 |
| WO2024211577A1 (en) | 2023-04-05 | 2024-10-10 | Massachusetts Institute Of Technology | Hybrid polymeric systems and methods of use thereof |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB532822A (en) * | 1939-08-11 | 1941-01-31 | John David Kendall | Improvements in and relating to the production of ª‡-coumarilyl and ª‡-thionaphthenoyl-acetic acid esters |
| GB1383114A (en) * | 1972-06-22 | 1975-02-05 | English Electric Valve Co Ltd | Magnetrons |
| US4342689A (en) | 1980-04-28 | 1982-08-03 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
| US4342691A (en) | 1980-04-28 | 1982-08-03 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
| US4342690A (en) | 1980-04-28 | 1982-08-03 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
| US4299769A (en) * | 1980-04-28 | 1981-11-10 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
| EP0146243A1 (en) | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase inhibitors |
| DE68924308T2 (de) * | 1988-07-11 | 1996-04-04 | Akzo Nobel Nv | Pyridazinon-Derivate. |
| AU675680B2 (en) | 1992-10-14 | 1997-02-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| US5569655A (en) | 1993-09-14 | 1996-10-29 | Sterling Winthrop Inc. | Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof |
| WO1999062897A1 (en) | 1998-06-03 | 1999-12-09 | Merck & Co., Inc. | Hiv integrase inhibitors |
| US6262055B1 (en) | 1998-06-03 | 2001-07-17 | Merck & Co., Inc. | HIV integrase inhibitors |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| CA2404002A1 (en) | 2000-03-24 | 2001-09-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| AU2002234755A1 (en) | 2001-02-26 | 2002-09-12 | Pharma Pacific Pty Ltd | Interferon-alpha induced gene |
| PT1537878E (pt) | 2002-07-03 | 2010-11-18 | Ono Pharmaceutical Co | Composições de imunopotenciação |
| US7521051B2 (en) | 2002-12-23 | 2009-04-21 | Medimmune Limited | Methods of upmodulating adaptive immune response using anti-PD-1 antibodies |
| WO2004072286A1 (ja) | 2003-01-23 | 2004-08-26 | Ono Pharmaceutical Co., Ltd. | ヒトｐｄ−１に対し特異性を有する物質 |
| US7576122B2 (en) | 2003-09-02 | 2009-08-18 | Merck & Co. Inc. | Ophthalmic compositions for treating ocular hypertension |
| AU2005221717B2 (en) | 2004-03-15 | 2010-08-05 | Karagen Pharmaceuticals, Inc. | Method for stimulating the immune, inflammatory or neuroprotective response |
| BRPI0610235B8 (pt) | 2005-05-09 | 2021-05-25 | Squibb & Sons Llc | anticorpos monoclonais geneticamente modificados e diferentes daqueles encontrados na natureza, ou porção de ligação ao antígeno dos mesmos, usos terapêuticos dos mesmos, composições, imunoconjugado, molécula biespecífica compreendendo os mesmos, molécula de ácido nucléico e vetor de expressão |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| EP1782826A1 (en) | 2005-11-08 | 2007-05-09 | GBF Gesellschaft für Biotechnologische Forschung mbH | PQS and c-diGMP and its conjugates as adjuvants and their uses in pharmaceutical compositions |
| EP3222634A1 (en) | 2007-06-18 | 2017-09-27 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
| US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| EP2328919A2 (en) | 2008-08-25 | 2011-06-08 | Amplimmune, Inc. | Pd-i antagonists and methods for treating infectious disease |
| US8552154B2 (en) | 2008-09-26 | 2013-10-08 | Emory University | Anti-PD-L1 antibodies and uses therefor |
| WO2010047774A2 (en) | 2008-10-20 | 2010-04-29 | The Texas A & M University System | Inhibitors of mycobacterium tuberculosis malate synthase, methods of marking and uses thereof |
| KR20170113681A (ko) | 2008-12-09 | 2017-10-12 | 제넨테크, 인크. | 항-ｐｄ-ｌ１ 항체 및 ｔ 세포 기능을 향상시키기 위한 그의 용도 |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| WO2012068702A1 (zh) * | 2010-11-23 | 2012-05-31 | 中国医学科学院医药生物技术研究所 | 苯并五元不饱和杂环类化合物及其制备方法 |
| JP5887947B2 (ja) | 2011-03-28 | 2016-03-16 | ソニー株式会社 | 透明導電膜、ヒータ、タッチパネル、太陽電池、有機ｅｌ装置、液晶装置および電子ペーパ |
| US9156872B2 (en) | 2011-04-13 | 2015-10-13 | Merck Sharp & Dohme Corp. | 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| BR112014002353B1 (pt) | 2011-08-01 | 2022-09-27 | Genentech, Inc | Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit |
| IN2014MN02492A (es) | 2012-06-08 | 2015-07-17 | Aduro Biotech | |
| CN103840995B (zh) | 2012-11-26 | 2017-10-24 | 华为技术有限公司 | Ip报文处理方法、装置及网络系统 |
| CN105008381B (zh) | 2012-12-13 | 2018-08-07 | 艾杜罗生物科技公司 | 包含具有确定立体化学的环嘌呤二核苷酸的组合物及其制备和使用方法 |
| US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
| US10336786B2 (en) | 2012-12-19 | 2019-07-02 | Board Of Regents, The University Of Texas System | Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway |
| EP2970119B1 (en) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| JP2016518140A (ja) | 2013-05-03 | 2016-06-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｉ型インターフェロンの環状ジヌクレオチド誘導法 |
| WO2014189806A1 (en) | 2013-05-18 | 2014-11-27 | Aduro Biotech, Inc. | Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| ME03586B (me) | 2013-05-18 | 2020-07-20 | Univ California | Sastavi i metode za aktiviranje signaliziranja koje je zavisno od .,stimulatora gena za interferon" |
| US10176292B2 (en) | 2013-07-31 | 2019-01-08 | Memorial Sloan-Kettering Cancer Center | STING crystals and modulators |
| JP2016538344A (ja) * | 2013-11-19 | 2016-12-08 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 癌処置としてのｓｔｉｎｇアゴニストの使用 |
| EP3071229A4 (en) | 2013-11-22 | 2017-05-10 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
| US9315523B2 (en) | 2013-12-06 | 2016-04-19 | Rutgers, The State University Of New Jersey | Cyclic dinucleosides |
| WO2015143712A1 (en) | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
| EP3131914B1 (en) | 2014-04-16 | 2023-05-10 | Idenix Pharmaceuticals LLC | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| CN103908468B (zh) | 2014-04-21 | 2017-02-08 | 上海捌加壹医药科技有限公司 | 环二核苷酸cGAMP在制备抗肿瘤药物中的应用 |
| WO2015185565A1 (en) | 2014-06-04 | 2015-12-10 | Glaxosmithkline Intellectual Property Development Limited | Cyclic di-nucleotides as modulators of sting |
| US20170121315A1 (en) | 2014-06-12 | 2017-05-04 | Bayer Pharma Aktiengesellschaft | Heterobicyclically substituted 4-oxobutane acid derivatives and use thereof |
| US20170340658A1 (en) | 2014-12-16 | 2017-11-30 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
| ES2764178T3 (es) | 2014-12-16 | 2020-06-02 | Kayla Therapeutics | Dinucleótidos cíclicos fluorados para inducción de citocinas |
| CN112626153A (zh) | 2014-12-17 | 2021-04-09 | 立博美华基因科技有限责任公司 | 用cGAMP或cGAsMP治疗癌症的方法 |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CN107530415A (zh) * | 2015-03-10 | 2018-01-02 | 艾杜罗生物科技公司 | 用于活化“干扰素基因刺激物”依赖性信号传导的组合物和方法 |
| WO2017011622A1 (en) | 2015-07-14 | 2017-01-19 | Spring Bank Pharmaceuticals, Inc. | Compounds and compositions that induce rig-i-and other pattern recongnition receptors |
| US10844051B2 (en) | 2015-07-22 | 2020-11-24 | The Royal Institution For The Advancement Of Learning/Mcgill University | Substituted oxazoles for the treatment of cancer |
| US10106574B2 (en) | 2015-08-13 | 2018-10-23 | Merck Sharp & Dohme Corp. | Cyclic di-nucleotide compounds as sting agonists |
| US9809597B2 (en) | 2015-08-20 | 2017-11-07 | The Board Of Trustees Of The Leland Stanford Junior University | Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy |
| JP2018534295A (ja) | 2015-10-28 | 2018-11-22 | アドゥロ バイオテック，インク． | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達を活性化するための組成物および方法 |
| AU2016362697B2 (en) | 2015-12-03 | 2018-07-12 | Glaxosmithkline Intellectual Property Development Limited | Cyclic purine dinucleotides as modulators of STING |
| EP3386536A4 (en) | 2015-12-07 | 2019-07-31 | Opi Vi- IP Holdco LLC | COMPOSITION OF ANTIBODY CONSTRUCT AGONIST CONJUGATES AND METHOD FOR USE THEREOF |
| BR112018013808A2 (pt) | 2016-01-11 | 2018-12-11 | Innate Tumor Immunity, Inc. | dinucleotídeos cíclicos para o tratamento de condições associadas à atividade de sting, tal como câncer |
| WO2017123657A1 (en) | 2016-01-11 | 2017-07-20 | Gary Glick | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
| AU2017233068C1 (en) | 2016-03-18 | 2023-05-25 | Immune Sensor, Llc | Cyclic di-nucleotide compounds and methods of use |
| CA3019628A1 (en) | 2016-04-07 | 2017-10-12 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators |
| PE20181920A1 (es) | 2016-04-07 | 2018-12-11 | Glaxosmithkline Ip Dev Ltd | Amidas heterociclicas utiles como moduladores de proteinas |
| MX2018015483A (es) | 2016-06-13 | 2019-03-18 | Glaxosmithkline Ip Dev Ltd | Piridinas sustituidas como inhibidores de adn metiltransferasa-1 (dnmt1). |
| US11098077B2 (en) | 2016-07-05 | 2021-08-24 | Chinook Therapeutics, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| CR20190168A (es) * | 2016-10-04 | 2019-05-17 | Merck Sharp & Dohme | Compuestos de benzo[b]tiofeno como agonistas de sting |
| EP3661498A4 (en) * | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme Corp. | BENZO [B] THIOPHEN STING ANTAGONISTS FOR CANCER TREATMENT |
| MA49773A (fr) * | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme | Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[b |
-
2017
- 2017-10-02 CR CR20190168A patent/CR20190168A/es unknown
- 2017-10-02 MA MA46452A patent/MA46452B1/fr unknown
- 2017-10-02 DK DK17784507.0T patent/DK3523287T3/da active
- 2017-10-02 MY MYPI2019001742A patent/MY196383A/en unknown
- 2017-10-02 GE GEAP201715066A patent/GEP20217285B/en unknown
- 2017-10-02 EP EP17784507.0A patent/EP3523287B1/en active Active
- 2017-10-02 KR KR1020197012543A patent/KR102312721B1/ko active IP Right Grant
- 2017-10-02 PT PT17784507T patent/PT3523287T/pt unknown
- 2017-10-02 TN TNP/2020/000159A patent/TN2020000159A1/en unknown
- 2017-10-02 PE PE2019000764A patent/PE20190705A1/es unknown
- 2017-10-02 MD MDE20190899T patent/MD3523287T2/ro unknown
- 2017-10-02 CA CA3038903A patent/CA3038903C/en active Active
- 2017-10-02 US US15/722,093 patent/US10414747B2/en active Active
- 2017-10-02 WO PCT/US2017/054688 patent/WO2018067423A1/en active Application Filing
- 2017-10-02 JO JOP/2019/0070A patent/JOP20190070B1/ar active
- 2017-10-02 UA UAA201904737A patent/UA125223C2/uk unknown
- 2017-10-02 TN TNP/2020/000158A patent/TN2020000158A1/en unknown
- 2017-10-02 SG SG10202008647TA patent/SG10202008647TA/en unknown
- 2017-10-02 MX MX2019003829A patent/MX2019003829A/es unknown
- 2017-10-02 PL PL17784507T patent/PL3523287T3/pl unknown
- 2017-10-02 CN CN201780070494.2A patent/CN110036001B/zh active Active
- 2017-10-02 AU AU2017339418A patent/AU2017339418C1/en active Active
- 2017-10-02 ES ES17784507T patent/ES2893532T3/es active Active
- 2017-10-02 AR ARP170102751A patent/AR109788A1/es unknown
- 2017-10-02 HR HRP20211617TT patent/HRP20211617T1/hr unknown
- 2017-10-02 TW TW106134034A patent/TWI796306B/zh active
- 2017-10-02 EA EA201990846A patent/EA037626B1/ru unknown
- 2017-10-02 LT LTEPPCT/US2017/054688T patent/LT3523287T/lt unknown
- 2017-10-02 JP JP2019517943A patent/JP6636673B2/ja active Active
- 2017-10-02 RS RS20211230A patent/RS62410B1/sr unknown
- 2017-10-02 SI SI201730918T patent/SI3523287T1/sl unknown
- 2017-10-02 HU HUE17784507A patent/HUE056502T2/hu unknown
-
2019
- 2019-03-27 IL IL265678A patent/IL265678B2/en unknown
- 2019-04-01 PH PH12019500712A patent/PH12019500712A1/en unknown
- 2019-04-03 NI NI201900029A patent/NI201900029A/es unknown
- 2019-04-03 DO DO2019000083A patent/DOP2019000083A/es unknown
- 2019-04-03 CL CL2019000902A patent/CL2019000902A1/es unknown
- 2019-04-04 CO CONC2019/0003349A patent/CO2019003349A2/es unknown
- 2019-04-12 EC ECSENADI201926680A patent/ECSP19026680A/es unknown
- 2019-07-16 US US16/513,417 patent/US10730849B2/en active Active
- 2019-07-16 US US16/513,409 patent/US10703738B2/en active Active
-
2021
- 2021-10-22 CY CY20211100924T patent/CY1124837T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CR20190168A (es) | Compuestos de benzo[b]tiofeno como agonistas de sting | |
| CO2017002998A2 (es) | Derivados de tetrahidronaftaleno que inhiben la proteína mcl-1 | |
| DOP2019000030A (es) | Inhibidores de cdk2/4/6 | |
| CO7141456A2 (es) | Derivados de aril-sultamo como moduladores de rorc | |
| CR20160523A (es) | Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer | |
| AR078278A1 (es) | Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro. | |
| BR112019000696A2 (pt) | antagonistas de tlr7/8 e uso dos mesmos | |
| CL2016001287A1 (es) | Benzamidas sustituidas y procedimiento para su uso | |
| PH12015501934A1 (en) | New octahydro - pyrrolo [3,4-c] - pyrrole derivatives and analogs thereof as autotaxin inhibitors | |
| UY35834A (es) | Piperazinas de pirazolo sustituido como inhibidores de caseína quinasa 1 delta y epsilon | |
| MD3313817T2 (ro) | Derivați biciclici, un procedeu pentru prepararea lor și compozițiile farmaceutice care îi conțin | |
| GT201600091A (es) | Derivados de purina 2, 6-sustituidos y su uso en el tratamiento de trastornos proliferativos | |
| NI201400023A (es) | Derivados de pirrolopirimidina y purina | |
| CO2017000438A2 (es) | Ácidos carboxílicos heterocíclicos como activadores de guanilato ciclasa soluble | |
| SV2016005351A (es) | Derivados de indano e indolina y el uso de los mismos como activadores de la guanilato ciclasa soluble | |
| CR20170496A (es) | Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones víricas | |
| UY36677A (es) | Compuestos tricíclicos como agentes antineoplásicos | |
| SV2016005310A (es) | Derivados de diheterociclo enlazado a cicloalquilo | |
| GT201100039A (es) | Agentes antifúngicos | |
| CL2020000439A1 (es) | Sales de un compuesto y sus formas cristalinas. | |
| CU20140033A7 (es) | Derivados de pirrolopirimidina y purina |