KR100314666B1 - A method and network system for genome genealogy and family genome information service - Google Patents

Abstract

The present invention relates to a method and system for storing, managing, and providing genetic information in a family or a household of a certain size. In the present invention, a method for producing and providing genome genealogy in a family of a descendant, parent, and sibling, or a pedigree of a certain scale, by a database of personal genomic information obtained by analyzing genes of a client who is a service user. And a system is provided. The server system may store a genome in a predetermined form selected by a user according to a personal genomic database for storing and managing individual genetic information, a member information database for storing and managing personal personal information and family tree information of members, and family tree information of registered members. Means for generating pedigrees and genome genealogy databases for storing and managing the generated genomes.

Description

A METHOD AND NETWORK SYSTEM FOR GENOME GENEALOGY AND FAMILY GENOME INFORMATION SERVICE}

The present invention relates to a method and system for storing, managing, and providing genetic information in a family or a household of a certain scale, and in particular, in a group unit registered through a network such as the Internet by storing individual genomic information in a server system. The present invention relates to a method and a system for providing genomic genealogy and genetic information of a family. All living organisms, including humans, have a characteristic of breeding an individual that resembles itself, which is called a genetic phenomenon, and this genetic phenomenon is a cell nucleus. It is made by genetic material called 'DNA' in the inside.

Humans have not only conserved and evolved races by genetic phenomena, but all biological and sociological activities and developmental processes such as birth, growth, disease and death of each individual are closely related to gene expression. This series of biological and sociological phenomena is stored in several genes as encoded genetic information.

Gene is the genetic information necessary to make protein, the most important component of life phenomenon, and the base sequence of DNA, that is, the sequence of bases called arginine (A), thiamine (T), guanine (G), and cytosine (C). Represented by The three consecutive sequences in the DNA are called codons (C), which are then transcribed into RNA and then translated into specific amino acids to create a protein that combines several amino acids, which protein in the cell They form major structures and mediate reactions that determine the fate of humans through the role of hormones and enzymes.

The term genome, which is a synthesis of genes and chromosomes, refers to the collection of all the DNA information of an organism. Every cell in an individual has the same number of chromosomes and genetic information. Because only one cell can be analyzed, the whole genome can be known.

As far as is known, the human genome consists of about 3 billion pairs of DNA sequences, and according to a recently published genome project, it is known that there are about 3 to 40,000 genes exhibiting a certain function. And about 10,000 of these genes have been shown to function. However, it is thought that it is only a matter of time before the completion of the human genetic map reveals these genes' functions.

Even if the genes showing the same traits (eg race, blood type, etc.) have different sequences in each person, the characteristic gene fragments of these individuals are called alleles. Even though the same gene is different in each individual, the cause of all individual differences is explained by the concept of single nucleotide variation called SNP (single nucleotide polymorphism), which is the concept of SNP. Most importantly, the single base mutation can reveal the genetic and biological characteristics of each individual. These genetic factors are also associated with all human diseases, which vary in their resistance, sensitivity, and degree of disease, depending on the individual SNP differences.

Each individual's characteristic gene fragments, or alleles, are necessarily inherited and passed down to their offspring, resulting in genetic and biological characteristics that are continuity and specificity, and form the basis of race breeding. Therefore, analyzing individual DNA based on pedigree will show continuity, purity and specificity of lineage. In addition, if all gene functions are identified as the genomic research progresses in the future, the biological and genetic problems including personality, disease, and growth of each individual can be identified and prevented, treated, and corrected from the genome genealogy. By analyzing the genetic characteristics and problems of a family (pedigree) or household, it will also be possible to treat the disease fundamentally through prophylaxis or genetic correction.

The present invention has been made in view of this point, and an aspect of the present invention provides a genome genealogy that allows the genetic analysis of a family or pedigree to be seen through DNA analysis of each individual based on the family or pedigree. It's about doing.

Our nation is exceptionally interested in the preservation and continuity of the family line, and the existence of genealogy in our country has been considered symbolically very important. However, through generations and generations, the number of descendants of each family increased enormously, and the genealogy such as the genealogy of the genealogy and the social changes such as the historical fluctuations of the Japanese colonial period, the influx of capitalism, and the fall of the opposition class in the late Joseon Dynasty have significant meanings. It can be said that it is distorted and lost a lot of purity.

Therefore, biological and genetic genealogy, meaning the preservation and purity of true lineage, will attract more attention than the formal family tree on the paper. Actual biological and genetic genealogies, unlike conventional genealogies, which are documented pedigrees, will provide practical usefulness to members of the household in terms of the prevention and treatment of diseases, in particular the prevention and treatment of genetic diseases.

At present, the completion of the first human genome project has produced a human genetic map and its research results are freely available to all human beings. In the future, research on functional genomics, which identifies the function of genes whose sequences have been determined, and comparative genomics, which identify the causes of biological function differences through comparison of genomic information between individuals, races, and patients, will be conducted.

Currently, 90% of human genes have not yet been identified, but as the study proceeds, the secrets will be revealed gradually. When these results are organized by family and household, the prevention and treatment of diseases will be greatly improved. Will be developed.

Accordingly, another aspect of the present invention provides predictive and warning diseases and the onset of genetic diseases by providing the genetic information according to the future research results as well as the human genetic information known to date in association with genome genealogy of a family or family. It relates to a genetic information providing system to prevent the.

An object of the present invention is to provide the desired genomic family tree and family genetic information for the family or pedigree of a certain size in a registered group unit by database the personal genomic information obtained by analyzing the gene of the client as a service user in the server system It is to provide a method and system.

Another object of the present invention is to confirm the purity and paternity of households by showing the genetic flow of the individual, family, and family (specifically the individual identification gene flow and specific trait or disease-related gene flow) through the genome genealogy produced It is to provide knowledge about genetic trends and genetic diseases in households, and to provide countermeasures and necessary information.

Another object of the present invention is to continuously collect and analyze the results of genome-related research and compare it with the stored personal genomic information of the client, or to supplement the server system with new information data related to the client individual, family or household genes. It is to provide new genetic information.

Another object of the present invention is to provide a family genetic information that can be used immediately when necessary (in the case of blood relationship, spouse selection, disease, transplantation, identification, etc.) by systematically database the genetic information in the family, family unit It is to provide a service system.

1 is a flowchart illustrating a process of registering a member and collecting necessary information.

Figure 2a shows the results of electrophoresis analysis of the STR locus.

3 is a block diagram illustrating an embodiment of the present invention.

4 and 5A illustrate one embodiment of the database structure of the present invention.

5B, 5C, and 6A illustrate one embodiment of generating genome genealogies.

6B-6C illustrate the forms provided on the user screen of the client system as one embodiment of the created genome genealogy.

In the present invention, a client (hereinafter referred to as a "user") who is a service user provides his personal information, family tree information, and genetic information to the server side, and the server system analyzes, classifies, and databases the information collected from the user. Genome genealogy will be produced and provided by family or household unit, a registered user group, and related genetic information will be provided.

In one embodiment of the present invention, a user becomes a member who accesses a server system through the Internet, accepts certain conditions, and joins. Members include group members and their members, such as family members, household units of scale or audience. However, after joining a member as an individual, it may be additionally registered as a group member as the household is formed later. The server system assigns a specific ID to a member, and assigns a personal ID for each member together with the group ID given to the group. Individual members who join as individuals are first assigned a personal ID, and when a new household is formed by marriage or childbirth, a group ID is assigned to the household.

The personal information provided by the user to the server side includes all information that can be directly input from the user and family tree information for genome genealogy. Genetic information provided to the server by the user becomes gene and chromosome information of each individual (each member and individual member of a group member), that is, analyzed individual genome information. In an embodiment of the present invention, the user provides hair roots, saliva, blood, etc. as a sample necessary for genetic testing, and the provided sample is passed through the analysis of the genetic analysis institution, and the necessary genetic information is sent to the server side. Is provided.

The server side constructs a database by analyzing and classifying personal information and genetic information collected from a user. According to an embodiment of the present invention, a server system includes a genome pedigree in a certain form according to a personal genome database including genetic information of a member, a member database including personal personal information and family tree information of a member, and family tree information of a registered group. And a genome genealogy database for storing and managing the generated genome genealogy.

The server system including the database as described above may produce and provide genome genealogy of a family or a family in a group unit registered according to a client's request, and provide household genetic information.

If the household composition changes due to the birth, death, or marriage of the client's household members, it is changed and stored in the member database, and the gene analysis result of the newly added member is input and stored in the personal genome database so that new genomic family tree can be provided. In addition, the personal genomic database continuously supplements and stores the genomic information of the client individual for a specific gene, etc. newly published according to the genome research results, reflects the new genetic information in the genome family generation, and stores related genetic information. To provide.

Hereinafter, exemplary embodiments of the present invention will be described with reference to the accompanying drawings. FIG. 1 is a flowchart illustrating a process of registering a member and collecting necessary information.

First, a user connects to a server using his computer, receives a registration guide, and selects a member type (steps 111 to 113). The member type may be presented in various forms. In one embodiment, a member type includes a member for limiting personal gene information provided by a user to a personal identification gene; A member providing genetic information of known personal identification genes and functions; It is divided into members that provide genetic information about the entire genome. However, member types may be further subdivided as necessary to provide only STR locus information of an autosomal among individual identification genes, and a case of providing personal identification genes and disease related gene information. According to the member type selection, the range of services that the client can receive from the server side, that is, genome genealogy, is also changed. This diversification of membership types would be appropriate, given that genomic information is highly personal information related to individual privacy. These types of membership may also be related to relevant legislation and, if necessary, may be subdivided or appropriately integrated to accommodate the various needs of the members.

When the member type is selected, the server system sends a web page to the user showing the corresponding subscription condition. Subscription conditions include the conditions required by the server side to provide other services, such as subscription fees, acceptance of necessary terms and agreements on gene sampling. Regarding personal information that requires the permission of household members, procedures such as their consent or confirmation online or offline may be added. Those skilled in the art will appreciate that such conditions may be omitted or added as needed.

If the user accepts the conditions of membership, a member information input window corresponding to the member type is provided from the server system (steps 114 to 115). The member information input window is provided for inputting household information and personal identification information of the household members necessary for preparing the family tree. Personal information may include, for example, general personal information such as name, address, social security number, occupation, photograph, height, weight, blood type, genetic trends such as color blindness, baldness, and histories (diabetes, high blood pressure, thyroid disease, cancer). Etc.) and all possible information that can be directly input by the user, and additionally, necessary information such as blood pressure, blood sugar, and visual acuity may be input by adding an expert's diagnosis step if necessary. The configuration of the member information input window may vary depending on the member type selected in the previous step, may be added or reduced as necessary, and may be supplemented later.

If member information is entered (step 115), the group ID of the group itself and the personal ID for each member are assigned from the server system (step 116). The server system stores the member information input from the user in the member database. In addition to the information on the group's household structure and personal information of the household members, the member information includes identification of member types and passwords of individuals and groups for the security of the information. For the user, the server side provides guidance on gene harvesting. Depending on the type of member, samples that can be collected relatively easily, such as hair roots and saliva, are preferentially selected, and when a large amount of DNA is required due to the characteristics of the test, blood is selected as a sample. Containers or packs can be provided to the user by mail, courier, etc., by the service provider, and the collected samples can be sent back to a designated analytical institution (gene bank) in a similar manner. For samples that are difficult to collect by the user, such as blood, a collection process by an expert may be added.

The user provides a gene sample (hair root, saliva, blood, etc.) for gene collection according to the method suggested by the server side (step 117), and the provided gene sample is sent to a genetic analysis institution (gene bank, etc.) to perform the necessary gene analysis. After that (step 118), the obtained personal genomic information is sent to the server side (step 119). In one embodiment, the gene is cryopreserved in a gene bank for further later analysis. Gene analysis and analyzed gene information, ie, individual genome information, will be described.

Genetic analysis of the necessary items is performed according to the client's request, that is, the member type selected by the user.

First, the gene sample provided by the user is extracted with DNA using a general DNA extraction method, and then amplified by using a widely used PCR (Polymerase Chain Reaction) method, which provides only genetic information limited to an individual identifier gene. For members, only personally identifiable genes are analyzed. Currently known personal identification genes are: 1) the short tandem repeats (STR) locus of the autosomal, 2) the STR locus of the Y chromosome, and 3) the hypervariable region (HVR) of the mitochondrial DNA. .

In the case of STR locus, there is no specific function, but the sequence group is repeated in a certain order (for example, AATTCCGT), and the number of repetitions varies from person to person, and thus can be used for personal identification. In the case of autosomal STR loci, they are inherited in pairs, one from each of the mother and the father, and thus generally represent two different repetitions (eg, 11-12, 07-15 .... And the like, but sometimes the same number) (see FIG. 2A). On the other hand, the STR locus of the Y chromosome is always inherited from father to son, so it always shows the same number of repetitions. Thus, the STR locus of the Y chromosome is an important clue for paternity between father and son. Mitochondrial DNA is a rather unusual DNA that is inherited from other DNA, consisting of about 16,000 bases, most of which differ among people. The two parts, HVR I and HVR II, called hypervariable regions (HVRs), consist of about 1.4 KB in length, or about 1,400 bases, of which about 800 mutations have been reported to vary from person to person. Among them, there are reported about 20 sites in HVR I and HVR II where mutations are distinct in each person. Because mitochondrial DNA exists in the cytoplasm, not in the nucleus, when the ovum and sperm are fertilized, the sperm discards the cytoplasm and only the nucleus enters the egg, so that only mitochondrial DNA on the mother's side is inherited. Thus, mitochondrial DNA is an important clue to the maternal origin.

Individual identification genes can be used to analyze the STR locus of autosomal chromosomes, the STR locus of Y chromosomes, and the hypervariable region (HVR) sequences of mitochondrial DNA. It may be. Those skilled in the art will know which genetic analysis should be included at the request of the member.

In general, the analysis of the STR locus is performed by DNA extraction, followed by amplification by electrophoresis, followed by electrophoresis, and the electrophoresis results are analyzed by viewing a gel document, which is a photosensitive photograph in the light of an X-ray film or ultraviolet light (FIG. 2a). Figure 2a shows the results of electrophoresis analysis of the STR locus. Mitochondrial DNA uses autosequencers to determine sequencing. The resulting personally identifiable gene information is sent to the server. In the case of STR locus, the genetic information includes the locus position and the number of repetitions of the locus. In the case of mitochondrial DNA, the genetic information includes the location of the hypervariable region and the sequence analyzed (ie, A, C, G, T 4). Order of branch bases). Personally identifiable gene information sent to the server system is stored in the personal genome database.

For members who provide information on specific trait or disease-related genes in conjunction with personally identifiable genes, analyzes for genes with these specific functions are performed. Human genes consist of 3 billion pairs of nucleotide sequences, but many of them do not show any particular traits, of which about 26,000 to 40,000 genes have been identified recently. These trait genes determine many things such as human appearance, blood type, personality, aptitude, aging, disease, and so on. To date, only about 10,000 genes have been shown to function, and some of them are known to cause diseases such as cancer by mutation. For example, mutations in BRCA I on chromosome 17 or BRCA2 on chromosome 13 are known to cause breast cancer. Other ApoE genes known to cause dementia, ACE genes related to cardiovascular disease, hypertension, etc. are known, but most disease-related genes are still unknown, and are expected to turn out in the near future based on current trends. For members who want to provide information about the whole genome, the best thing would be to analyze the entire 3 billion pairs of sequences in the human genome from a given gene sample. However, in consideration of cost and time, it would be desirable to perform analysis based on genes whose function is known once, and store DNA and perform further analysis according to the genetic research results further revealed. After drying, the frozen DNA is known to be stored almost permanently, so it can be amplified and analyzed at any time in the future as needed. Gene information obtained from the analysis of these traits or disease-related genes is sent to the server system. This genetic information includes the sequence information analyzed (ie, the sequence of the four bases A, C, G, T) along with the location of the chromosome and gene. The server system stores the trait or disease related gene information in a personal genomic database to provide genetic information of the family related to the disease or specific trait and to generate genome genealogy.

3 is a block diagram illustrating an embodiment of the present invention. This embodiment uses the World Wide Web to provide the user with desired genomic genealogy and family genetic information over the Internet.

The server system 200 is a server engine 210. According to various web pages 220, personal genomic database 231 including genetic information of individuals, member information database 232 including family tree information of registered groups and personal information of group members, family tree of group members Genome generalogy generating means 211 for generating a pedigree in a certain form and a genome genealogy database 233 for storing the generated genome genealogy.

In addition, the server system includes a plurality of web pages 220 provided to a client system so that a user connected through the Internet can view the genome genealogy of the household to which they belong and their genetic information.

The server engine 210 receives an HTTP request for accessing a web page identified by a URL and provides a web page to client systems of various users.

Client system 240 is typically a user's personal computer. The client system 240 includes a web browser, and all messages sent from the client system to the server system include the user's ID (group ID and personal ID). The server system and the client system of the user accessing the server system communicate with each other. Information is exchanged over link 250, which in one embodiment includes transmission over the Internet. However, in other embodiments, the system can be used under a variety of environments other than the Internet. For example, various communication channels such as LAN and WAN may be used. The database 231.232.233 and the genome generalogy generating means 211 will be described with reference to the drawings of the database system.

4 and 5A illustrate an embodiment of the database structure of the present invention. The personal genome database stores and manages personal genome information in units of individual IDs (FIG. 4A). The personal genome information that is stored varies depending on the type of member. For example, some members store only personally identifiable gene information, and some members store specific trait and disease related gene information together with personally identifiable gene information.

Personally identifiable gene information may include the STR locus of the autosomal chromosomes, the STR locus of the Y chromosome, and the hypermutation region of mitochondrial DNA described above, or may include only one of them according to the segment type. These preferably constitute each file and are stored in the personal genome DB.

The autosomal STR locus would be desirable to analyze all possible loci and store the result in the DB in order to enhance individual identification, but if at least 9 digits are analyzed, the probability of having the same gene is very small. Adjust the analysis range accordingly. The autosomal STR locus usually binds three loci and uses them as a single probe.The most commonly used are CTT (CSF1P0 + TPOX + THO1), FFV (F13A01 + FES / FPS + VWA), and Silver (D16S539 + D7S820 + D13S317). In one embodiment, the STR locus and the number of repetitions of the autosomal obtained as a result of the analysis are stored for each individual ID to form a data file 310 of the autosomal STR locus. The data file 310 of the autosomal STR locus comprises a member record with an individual ID, and the record includes each STR locus of the autosomal (e.g., CSF1P0, TPOX, THO1, F13A01, FES, VWA, D16S539, D7S820, D13S317, etc.) are included in each field, and each field has a fixed number of iterations of the STR locus, for example, a large number first or a small number first. Therefore, it is expressed as 07-15, 06-13, 05-15, 06-14, etc. Many STR loci are known on the Y chromosome, and after analysis, they are databased by the same method as the STR locus of the autosomal Y. The STR locus data wave 320 of the chromosome is constructed. The Y chromosome is inherited only from the father and is not a pair, so only one number is displayed per locus, that is, one number per field. This data file plays a very important role in revealing the paternity of the father and son, and it is also an important clue to the purity of the household.

Genetic information of the over-mutation region of the mitochondrial DNA is preferably stored in a database of the genetic information of the analysis of over 40 nucleotide sequences that are distinct between individuals of the over-mutation region of the mitochondrial DNA. In one embodiment of the present invention, the data file 330 of the mitochondrial DNA is composed of each member record having an individual ID, and the record is a corresponding base number (for example, 73, 103, ... ), And each field contains a base (eg, A, C, G, T) corresponding to the base number. Store in genomic database. In the case of disease-related gene information, after analyzing the results of the analysis of the genes that have been identified so far by function and storing the corresponding sequencing information, preferably a separate data file (disease-related gene information file) (340) Configure. For example, the disease related gene data file 340 may include a BRCA gene (breast cancer related), ApoE gene (dementia related), ACE gene (hypertension related), and HPV gene (uterine cancer related) in each member record having an individual ID. Using the hMLH1,2 gene (colorectal cancer-related) field as the respective fields, the corresponding nucleotide sequence information (ie, the order of the four bases of A, C, G, and T) is input. In addition, the interpretation of the genetic analysis results can be stored together with the corresponding sequencing information. The information about these functional genes analyzes the DNA of the stored individual whenever new genetic information is revealed or at the request of the user, and stores the new genetic information in a database. The family tree information of the group and the personal information of the group members are stored (FIG. 5A). In one embodiment, the family tree information is stored for each registered group ID to form a family tree data file 410. The family tree data file includes family tree information such as the family tree and the individual ID of each member and location information in the family tree, and the stored family tree information is continuously supplemented and stored according to personal changes such as birth, death, and marriage of the family member. do. Personally identifiable information includes, for example, general personal information such as name, address, social security number, occupation, photograph, height, weight, blood type, genetic trends such as color blindness and baldness, and histories (diabetes, high blood pressure, thyroid disease, cancer). Etc.) and all possible information that can be input by the user directly, and information such as blood pressure, blood sugar, and visual acuity measured by an expert may be added as necessary. In one embodiment, the personal identification information is stored for each personal ID to form a personal identification information data file 420, and such personal identification information may be added or reduced as necessary.

When the member database 232 and the personal genomic database 231 are constructed as described above, genome genealogy can be created.

5B is a flowchart illustrating a process of preparing genome genealogy using the constructed DB.

First, a user who logs in with an ID and password requests creation of a genome genealogy (510). Such a request may be held until the necessary data is entered into the member database 232 and the personal genome database 231 after the initial registration process. By checking the member information stored in the member database 232 and the personal genome information stored in the gain genome database 231 from the corresponding ID, it is determined whether genealogy is possible (520, 530). Web pages that contain a message saying that you cannot create a genealogy if you are an individual member without family tree information, or if a member of the group has limited permission to view the genealogy, or if the personal genome information of the family member is not stored in the personal genome database. Is provided on the screen. When a registered group or group member having family tree information is authorized to view genealogy and personal genome information of each member is stored, a selection window including a type of genealogical genealogy and a description thereof is provided on the user screen (540). ). The type of genealogy that can be created is determined primarily by member type, and secondly by data stored in the personal genome database, and personal information can be added by selection. For example, in the case of a member providing only personal identification gene information to the server side, a screen as shown in FIG. 5C is provided. However, when the personal genomic database is checked and the information data on the mitochondrial DNA has not yet been entered, a screen excluding the selection items (3) and 5) items including the mitochondrial DNA is provided. When the user selects one of the items presented, a screen for additionally selecting personally identifiable information included in the genealogy is provided (step 550, FIG. 6A). If the personal identification information to be added is selected or not checked, the user's selection information is transmitted to the server system.

The server system receiving the user's selection information executes the genome genealogy generating means 211 to generate the genealogy. First, the family tree information and the personal identification information of the user are identified from the member database to construct a family tree that sets the correlation between the selected personal identification information and the household members (560). The configured family tree may be transmitted to the user screen to receive a confirmation of the user. The family tree form of the screen provided to the user may be a tree diagram or a table form. In addition, when the family tree is confirmed, the gene information of each member constituting the family according to the family tree type selected by the user is retrieved from the personal genomic database to complete the genome family tree (570, 580). For example, if the user selects selection item 2) of the genealogy type of FIG. 5C, the STR locus 9 locus of the autosomal and 20 locus STR loci of the Y chromosome are determined from the genetic information stored in the individual genomic database. They will be loaded in sequence to generate genome genealogy (for example, CSF1P0 → TPOX → THO1 → F13A01 → FES → VWA → D16S539 → D7S820 → D13S317 → DYS385 ....). FIG. 6B illustrates an embodiment (type provided on the user screen) of the genome genealogy thus produced. FIG. 6C is an embodiment of a genome genealogy generated when a user selects 2) of the genealogy types of FIG. 5C and then selects a photo in adding personally identifiable information (FIG. 6A).

As described above, depending on the type of genomic family tree selected by the user and the additional selection of personal identification information, the personal genomic information and the personal identification information which are imported from the personal genomic database and the member database are different. If you want to check the paternity, you can make a simple and clear genomic family tree using only the STR locus information of the Y chromosome. Likewise, if you want to identify the mother system, you can create a genomic family tree using only mitochondrial DNA information.

In the same way, genome family genes for disease-related genes or genome family genes for specific trait genes can be prepared. For example, if a user chooses to generate genealogy of dementia-related genes, the genealogy of ApoE genes from family members is retrieved from the personal genomic database. At this time, the narration stored in the DB along with the nucleotide sequence information of the ApoE gene may be provided together. For example, if you click on a member of the household you would like to view commentary on, you'll find that ApoE gene analysis shows that ApoE ₃ is a 77-80% chance of getting dementia. The completed genome family tree is provided to the user through a communication link. In one embodiment, the means for providing the genome genealogy to the user may be transmission over the Internet. However, for example, various communication channels such as an e-mail environment, a LAN, and a WAN may be used.

In addition, the created genome genealogy is stored in the genome genealogy database 233 so that it can be provided immediately when a user requests to view it. Therefore, in the genome generalogy process, the server system receiving the user's selection information may check whether the genome family tree matching the user's selection information is already stored in the genome family DB. If the genome genealogy of the type desired by the user is already stored in the genome genealogy database, the stored genome genealogy is immediately transmitted to the user to complete the genome provision. Services provided through the system of the present invention

The services that can be provided through the genome genealogy and genetic information providing system of the present invention are as follows.

1) Generation and Storage of Genome Genealogy The genome genealogy, which is a biological genealogy, is provided to the client by systematically analyzing and storing gene information of members in registered group units, such as small families, large families, or audiences, designated by the client. Genome genealogies are continually added as members increase and are constantly complemented by genomic studies.

According to the genome genealogy, the genetic trend of the household (color blindness, etc.) and the flow of genetic diseases can be seen, and the countermeasures can be established accordingly.

For example, in the case of families with recessive genetic diseases, it is possible to refer to the selection of spouses from a biological point of view by examining the possibility of genetic diseases caused by marriage with other families having the same recessive genetic factors.

In addition, by systematically database the genetic information on a family and a scale of household units, it is possible to immediately use the genetic information necessary in case of confirmation of blood relationship, spouse selection, disease, and organ transplantation.

However, these services will be subject to the request and consent of the parties as necessary.

2) Individual Genome Information Management User Analyzes the genome of individual and stores genomic information for each individual, and provides information on the possibility of disease occurrence and countermeasures according to the genetic and molecular biological research results.

By continuously collecting and analyzing research results related to the genome, and further analyzing the stored genomic information of the client or the stored DNA as needed, new genetic information is added to the personal genomic database to provide users with new genetic information such as the possibility of disease. do.

For example, if a recent study found that diabetes is likely to occur when certain sequences of certain genes are modified, immediately retrieve the data stored in the personal genomics database or re-analyze the stored DNA and write the results into the database. Add and notify the parties so that appropriate measures such as prevention can be taken.

In addition, by permanently preserving the user's healthy genome analysis results and samples, in the future the user can be used for treatment by providing comparative information in case of a disease caused by genomic modifications.

As genome-related research is developed in the future, related technologies such as genetic modification are expected to be developed. Therefore, information and countermeasures necessary for life extension or gene therapy related to a specific disease are presented.

In addition, as a service that can be additionally provided, it is possible to verify the identity when a client dies in an unidentified state due to an accident or crime by using a personal genomic database in which a personal identification gene is stored.

The present invention is not limited by the above-described embodiments, and various modifications and variations are made by those skilled in the art to which the present invention pertains without departing from the spirit and scope of the present invention. Of course this is possible.

According to the genome genealogy and genetic information providing system of the present invention, by systematically database the genetic information into families, a scale of household units, it can be immediately used when necessary (checking blood relationship, spouse selection, disease, transplant surgery, etc.), Genetic information in households is managed efficiently, and the results of genetic research that will be revealed in the future will be immediately available.

Claims (9)

By storing individual genomic information in a server system and producing and providing genome genealogy of family or household by group registered member through communication link such as internet, Allocating a group ID of a group unit and a personal ID of each member to a user who accesses the server system; Collecting personal identification information of individual ID units and family tree information of group ID units from a user and storing the information in a member database of a server system; Inputting and storing information (personal genomic information) obtained by analyzing a genetic sample of each individual having the personal ID in a personal genome database of a server system in individual ID units; Upon receiving the user's genome family generation request including the group ID and the type of genome family tree desired, the family tree information and the personal information are identified from the member database to form a family tree, and the individual genome information of each member of the family tree is formed. Creating genome genealogies by extracting and retrieving from the individual genomic database according to the type of genome genealogy; Providing the created genome genealogy to a user through a communication link; Storing the created genome genealogy in a genome genealogy database to be provided when a user's reading request is requested later; Providing method of genomic family tree comprising a. The method of claim 1, wherein the genome generative step Receiving a genome generative request including a group ID from a user; Checking the received member information of the user from the member database to determine whether genealogy is possible; For a user who can create a genealogy step, providing a user with a selection window including a genealogy type and a description so that the user can select a genealogy type; If the user selects the pedigree type and additional personal information, the selected information is transmitted to the server system; Identifying, by the server system, the family tree information of the user stored in the member database according to the received selection information of the user to form a family tree; Extracting and retrieving the individual genomic information of each member constituting the formed family tree from the personal genomic database according to the type of genome family tree selected; Providing method of genome genealogy comprising a. 2. The server system of claim 1, wherein the server system that receives the user's genome generative request including the group ID and the type of genomic genealogy desired by the user, checks whether the genome family gene matching the user's request is stored in the genome genealogy database. If there is a stored genomic genealogy, the method for providing a genomic genealogy comprising the step of providing the genome genealogy is completed by transmitting it to the user. The method of claim 1, wherein the member database modifies and stores family tree information according to changes in household members due to birth, death, marriage, and the like. The method of claim 1, wherein the personal genomic database is chromosomal locus information of the autosomal; STR locus information of the Y chromosome; Mitochondrial DNA information; Method of providing a genome genealogy comprising at least one of the personally identifiable gene information. The method according to claim 1 or 5, The individual genomic database provides genomic genealogy, characterized in that it comprises information on genes related to the genes and diseases related to the present. It is a server system that stores genomic information of individuals and creates genome genealogies by group of registered family or household and provides them to client system through communication link such as internet. A member database that stores and manages personal identification information in units of individual IDs and family tree information in units of group IDs; A personal genome database that stores and manages genetic information (personal genome information) obtained by analyzing gene samples of each individual having an individual ID in units of individual IDs; Means for identifying a family tree information corresponding to a specific group ID from the member database to construct a family tree, and importing individual genome information of each family member from the individual genome database according to the configured family tree to create a genome family tree; Means for providing the created genome genealogy to a user through a communication link; A genome genealogy database that stores and manages the generated genome genealogy so that it can be provided later when a user requests a reading; Server system for providing genome genealogy comprising a. The method of claim 7, wherein The personal genomic database includes STR locus information of an autosomal body; STR locus information of the Y chromosome; Mitochondrial DNA information; Server system comprising one or more of the personally identifiable gene information. The method according to claim 7 or 8, The personal genomic database is a server system, characterized in that it contains information on the genes related to the traits and diseases related to the present.