Faculdade de Medicina - FM
URI Permanente desta comunidade
A Faculdade de Medicina da Universidade de São Paulo (FMUSP) foi fundada oficialmente em 24 de novembro de 1891, de acordo com a Lei nº 19, como 'Academia de Medicina, Cirurgia e Pharmácia'; a aula inaugural foi realizada anos mais tarde, em 1913, quando foi rebatizada como Faculdade de Medicina e Cirurgia de São Paulo, sendo designada como Faculdade de Medicina de São Paulo em 1925 e incorporada à Universidade de São Paulo em 1934.
A FMUSP está vincula ao Sistema FMUSP-HC, que é o maior do país e também o maior centro assistencial da América Latina, compreendendo, além da Faculdade de Medicina, institutos especializados no atendimento de alta complexidade (atenção terciária), hospital de média complexidade (atenção secundária), hospitais auxiliares, unidades especializadas no atendimento integral de pacientes portadores de HIV/AIDS, Centro de Saúde Escola (atenção primária), Unidades Básicas de Saúde (atenção primária), Laboratórios de Investigação Médica (LIMs) e Fundação de Apoio.
Atualmente a FMUSP atua na graduação e pós-graduação de médicos, fisioterapeutas, fonoaudiólogos e terapeutas ocupacionais com sólida formação geral e básica, além de promover o treinamento nos três níveis de atenção à saúde.
Entre as atividades realizadas na FMUSP estão pesquisa e desenvolvimento na área da saúde, além de pesquisa básica e clínica e o oferecimento de ensino, pesquisa e atividades de cultura e extensão, tendo como prioridade o investimento em pesquisa científica e sua reversão para projetos de assistência social.
Site oficial: http://www.fm.usp.br
A FMUSP está vincula ao Sistema FMUSP-HC, que é o maior do país e também o maior centro assistencial da América Latina, compreendendo, além da Faculdade de Medicina, institutos especializados no atendimento de alta complexidade (atenção terciária), hospital de média complexidade (atenção secundária), hospitais auxiliares, unidades especializadas no atendimento integral de pacientes portadores de HIV/AIDS, Centro de Saúde Escola (atenção primária), Unidades Básicas de Saúde (atenção primária), Laboratórios de Investigação Médica (LIMs) e Fundação de Apoio.
Atualmente a FMUSP atua na graduação e pós-graduação de médicos, fisioterapeutas, fonoaudiólogos e terapeutas ocupacionais com sólida formação geral e básica, além de promover o treinamento nos três níveis de atenção à saúde.
Entre as atividades realizadas na FMUSP estão pesquisa e desenvolvimento na área da saúde, além de pesquisa básica e clínica e o oferecimento de ensino, pesquisa e atividades de cultura e extensão, tendo como prioridade o investimento em pesquisa científica e sua reversão para projetos de assistência social.
Site oficial: http://www.fm.usp.br
Índice h
Scopus: 325
Navegar
Subcomunidades desta Comunidade
- Faculdade de Medicina - FM
- Faculdade de Medicina - FM
- Faculdade de Medicina - FM
- Faculdade de Medicina - FM
- Faculdade de Medicina - FM
- Faculdade de Medicina - FM
- Faculdade de Medicina - FM
- Faculdade de Medicina - FM
- Faculdade de Medicina - FM
- Faculdade de Medicina - FM
Submissões Recentes
Brazil has a problem: therapeutic itinerary, research and data about eating disorders
(2024) OLIVEIRA, Jonatas de; SANTOS, Thais di Stasi Marques dos; FERRO, Joao Luiz Coelho; STELMO, Isis de Carvalho
Try not to think about food: An association between fasting, binge eating and food cravings
(2024) OLIVEIRA, Jonatas de; FERRO, Joao; GUIMARAES, Victor Hugo Dantas; LUZ, Felipe Quinto da
Background: When individuals follow a diet or limit their food intake, they activate cognitive restraint, which is defined as a mental effort to restrict dietary behavior with the goal of losing weight. As an example, fasting has also been associated with the recruitment of cognitive restraint, but further research is needed to fully understand its underlying mechanisms. Aims: The aim of this study was to examine the relationship between the duration of fasting and disordered eating, such as food cravings, binge eating, and potential changes in eating habits. Methods: An online survey was conducted among 853 first-semester university students to investigate their fasting practices and frequency over a three-month period prior to data collection. Participants who were on diets were excluded (n = 214). After controlling the sample for biases, a comparison was made between 89 fasters and 369 non-fasters. The study compared levels of cognitive restraint, binge eating, food cravings, and consumption of 'forbidden' foods. A Poisson model was used to examine the association between hours of fasting and disordered eating traits. In the context of this study, the rate ratio was used to examine the relationship between fasting hours and disordered eating characteristics, such as binge eating and food cravings. Results: The study found that fasters experienced an increase in food cravings and binge eating. However, fasters consumed fewer bread slices than non-fasters. The rate ratio of fasting hours practiced is 115% higher among binge eaters (RR 2.15; CI95% 1.70-2.73) compared to those who did not binge. The rate ratio of fasting hours is 29% higher in participants with moderate binge eating (RR 1.29; CI95% 1.05-1.59), increasing to 140% (RR 2.40; CI95% 1.86-3.11) in people with severe binge eating. As for food cravings (state), the rate ratio was 2% higher (RR 1.02; CI 95% 1.01-1.03) for each increase in the unit of the scale. Conclusions: Our study has indicated that fasting is positively associated with increased levels of binge eating and food cravings.
Transcranial direct current stimulation improves seizures frequency in drug-resistant epilepsy: A systematic-review and meta-analysis of randomized controlled trials
(2024) LIMA, A. E.; TELLES, J. P.; DANTAS, J.; FERNANDES, A. C.; RIBEIRO, G. B. S.; BARBOSA, V. L.; CASTRO-LIMA, H.
Placental homogeneity: Characterizing transcriptional variation among equine chorioallantoic locations
(2024) VERSTRAETE, Margo H.; DINI, Pouya; ORELLANA, Daniela; URIBE-SALAZAR, Jose M.; VERAS, Mariana M.; CARNEIRO, Francieli; DAELS, Peter; FERNANDES, Claudia B.
The proper function of the placenta is essential for the health and growth of the fetus and the mother. The placenta relies on dynamic gene expression for its correct and timely development and function. Although numerous studies have identified genes vital for placental functions, equine placental molecular research has primarily focused on single placental locations, in sharp contrast with the broader approach in human studies. Here, we hypothesized that the molecular differences across different regions of the equine placenta are negligible because of its diffuse placental type with a macroscopic homogenous distribution of villi across the placental surface. We compared the transcriptome and stereological findings of the body, pregnant horn, and non-pregnant horn within the equine chorioallantois. Our transcriptomic analysis indicates that the variation between regions of the placenta within individuals is less than the variation observed between individuals. A low number of differentially expressed genes (DEGs) (n = 8) was identified when comparing pregnant and nonpregnant horns within the same placenta, suggesting a remarkable molecular uniformity. A higher number of DEGs was identified when comparing each horn to the body (193 DEGs comparing pregnant horn with body and 207 DEGs comparing non-pregnant horn with body). Genes with a higher expression in the body were associated with processes such as extracellular matrix synthesis and remodeling, which is relevant for placental maturation and placenta-endometrial separation at term and implies asynchrony of these processes across locations. The stereological analysis showed no differences in microcotyledonary density, and width between the locations. However, we observed a greater chorioallantoic thickness in the body and pregnant horn compared to the nonpregnant horn. Overall, our findings reveal a uniform transcriptomic profile across the placental horns, alongside a more distinct gene expression pattern between the uterine body and horns. These regional differences in gene expression suggest a different pace in the placental maturation and detachment among the placental locations.
Identification of common MicroRNAs expression signatures in antiphospholipid syndrome and thromboembolic disease: A scoping review
(2024) VAZ, Camila de Oliveira; JACINTHO, Bruna Cardoso; SANTOS, Gabrielle de Mello; OLIVEIRA, Jose Diogo de; MAZETTO, Bruna Moraes; GERALDO, Murilo Vieira; ORSI, Fernanda A.
Background Antiphospholipid syndrome (APS) is an acquired autoimmune disorder characterized by distinct pathophysiological mechanisms leading to heterogeneous manifestations, including venous and arterial thrombosis. Despite the lack of specific markers of thrombosis risk in APS, some of the mechanisms responsible for thrombosis in APS may overlap with those of other thromboembolic diseases. Understanding these similarities is important for improving the assessment of thrombosis risk in APS. MicroRNAs (MiRNAs) are RNA molecules that regulate gene expression and may influence the autoimmune response and coagulation.Purpose In this scoping review we aimed to investigate shared miRNAs profiles associated with APS and other thromboembolic diseases as a means of identifying markers indicative of a pro-thrombotic profile among patients with APS.Data collection and Results Through a comprehensive search of scientific databases, 45 relevant studies were identified out of 1020 references. miRs-124-3p, 125b-5p, 125a-5p, and 17-5p, were associated with APS and arterial thrombosis, while miRs-106a-5p, 146b-5p, 15a-5p, 222-3p, and 451a were associated with APS and venous thrombosis. Additionally, miR-126a-3p was associated with APS and both arterial and venous thrombosis.Conclusion We observed that APS shares a common miRNAs signature with non-APS related thrombosis, suggesting that miRNA expression profiles may serve as markers of thrombotic risk in APS. Further validation of a pro-thrombotic miRNA signature in APS is warranted to improve risk assessment, diagnosis, and management of APS.
Degree of food processing and breast cancer risk: a prospective study in 9 European countries
(2024) CAIRAT, Manon; YAMMINE, Sahar; FIOLET, Thibault; FOURNIER, Agnes; BOUTRON-RUAULT, Marie-Christine; LAOUALI, Nasser; MANCINI, Francesca Romana; SEVERI, Gianluca; BERSTEIN, Fernanda Morales; RAUBER, Fernanda; LEVY, Renata Bertazzi; SKEIE, Guri; BORCH, Kristin Benjaminsen; TJONNELAND, Anne; MELLEMKJAER, Lene; BORNE, Yan; ROSENDAHL, Ann H.; MASALA, Giovanna; GIRAUDO, Maria Teresa; MAGISTRIS, Maria Santucci de; KATZKE, Verena; BAJRACHARYA, Rashmita; SANTIUSTE, Carmen; AMIANO, Pilar; BODEN, Stina; CASTRO-ESPIN, Carlota; SANCHEZ, Maria-Jose; TOUVIER, Mathilde; DESCHASAUX-TANGUY, Melanie; SROUR, Bernard; SCHULZE, Matthias B.; GUEVARA, Marcela; KLIEMANN, Nathalie; LOPEZ, Jessica Blanco; NAHAS, Aline Al; CHANG, Kiara; VAMOS, Eszter P.; MILLETT, Christopher; RIBOLI, Elio; HEATH, Alicia K.; BIESSY, Carine; VIALLON, Vivian; CASAGRANDE, Corinne; NICOLAS, Genevieve; GUNTER, Marc J.; HUYBRECHTS, Inge
Recent epidemiological studies have suggested a positive association between ultra-processed food consumption and breast cancer risk, although some studies also reported no association. Furthermore, the evidence regarding the associations between intake of food with lower degrees of processing and breast cancer risk is limited.Thus, we investigated the associations between dietary intake by degree of food processing and breast cancer risk, overall and by breast cancer subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Dietary intake of EPIC participants was assessed via questionnaires at baseline. More than 11,000 food ingredients were classified into four groups of food processing levels using the NOVA classification system: unprocessed/minimally processed (NOVA 1), culinary ingredients (NOVA 2), processed (NOVA 3) and ultra-processed (NOVA 4). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of breast cancer per standard deviation increase in daily consumption (grams) of foods from each NOVA group.The current analysis included 14,933 breast cancer cases, diagnosed among the 318,686 EPIC female participants, (median follow-up of 14.9 years). No associations were found between breast cancer risk and the level of dietary intake from NOVA 1 [HR per 1 SD=0.99 (95% CI 0.97 - 1.01)], NOVA 2 [HR per 1 SD =1.01 (95% CI 0.98 - 1.03)] and NOVA 4 [HR per 1 SD =1.01 (95% CI 0.99 - 1.03)] foods. However, a positive association was found between NOVA 3 and breast cancer risk [HR per 1 SD =1.05 (95% CI 1.03 - 1.07)] which became non-significant after adjustment for alcohol intake [HR per 1 SD =1.01 (95% CI 0.98 - 1.05)] or when beer and wine were excluded from this group [HR per 1 SD =0.99 (95% CI 0.97 - 1.01)]. The associations did not differ by breast cancer subtype, menopausal status or body mass index. Findings from this large-scale prospective study suggest that the positive association between processed food intake and breast cancer risk was likely driven by alcoholic beverage consumption.
Quantitative and Qualitative Research in the Field of 'Spirituality and Health': An Introductory How-to-Guide from a Brazilian Perspective
(2024) LUCCHETTI, Giancarlo; LUCCHETTI, Alessandra Lamas Granero; VITORINO, Luciano Magalhaes; MARTIN, Elena Zuliani; ALMEIDA, Paulo Othavio de Araujo; DAMIANO, Bianca Besteti Fernandes; ALVARENGA, Willyane de Andrade; DAMIANO, Rodolfo Furlan
The present article aims to describe the different steps on how to design, develop and conduct quantitative and qualitative Spirituality and Health (S/H) studies from a Brazilian perspective, discussing definitions and instruments, and proposing a ""how-to guide"" for those interested in this field of research. A narrative review of the literature has been conducted by experts in the field of S/H aiming to develop a ""how-to-guide"". Spirituality is a very complex concept that has several challenges in the current scientific literature, including the lack of consensus in the definitions, the numerous dimensions assessed, the diverse instruments for measurement, the criticisms from other scholars, the great diversity of religious and cultural traditions and the growing number of ""spiritual but not religious"" individuals. This review supports that S/H studies may follow the high scientific standards, using consolidated research procedures and solid methods for both qualitative and quantitative research. Some peculiarities of the research methods for this field are discussed. S/H research is still under development, and there are several future directions for S/H studies, aiming to minimize previous criticisms and generating stronger evidence.
Association of holidays and the day of the week with suicide risk: multicounty, two stage, time series study
(2024) LEE, Whanhee; KANG, Cinoo; PARK, Chaerin; BELL, Michelle L.; ARMSTRONG, Ben; ROYE, Dominic; HASHIZUME, Masahiro; GASPARRINI, Antonio; TOBIAS, Aurelio; SERA, Francesco; HONDA, Yasushi; URBAN, Ales; KYSELY, Jan; INIGUEZ, Carmen; RYTI, Niilo; GUO, Yuming; TONG, Shilu; COELHO, Micheline de Sousa Zanotti Stagliorio; LAVIGNE, Eric; DE'DONATO, Francesca; GUO, Yue Leon; SCHWARTZ, Joel; SCHNEIDER, Alexandra; BREITNER, Susanne; CHUNG, Yeonseung; KIM, Sooin; HA, Eunhee; KIM, Ho; KIM, Yoonhee
OBJECTIVES To assess the short term temporal variations in suicide risk related to the day of the week and national holidays in multiple countries. DESIGN Multicountry, two stage, time series design. SETTING Data from 740 locations in 26 countries and territories, with overlapping periods between 1971 and 2019, collected from the Multi-city Multi-country Collaborative Research Network database. PARTICIPANTS All suicides were registered in these locations during the study period (overall 1 701 286 cases). MAIN OUTCOME MEASURES Daily suicide mortality. RESULTS Mondays had peak suicide risk during weekdays (Monday-Friday) across all countries, with relative risks (reference: Wednesday) ranging from 1.02 (95% confidence interval (CI) 0.95 to 1.10) in Costa Rica to 1.17 (1.09 to 1.25) in Chile. Suicide risks were lowest on Saturdays or Sundays in many countries in North America, Asia, and Europe. However, the risk increased during weekends in South and Central American countries, Finland, and South Africa. Additionally, evidence suggested strong increases in suicide risk on New Year's Day in most countries with relative risks ranging from 0.93 (95% CI 0.75 to 1.14) in Japan to 1.93 (1.31 to 2.85) in Chile, whereas the evidence on Christmas day was weak. Suicide risk was associated with a weak decrease on other national holidays, except for Central and South American countries, where the risk generally increased one or two days after these holidays. CONCLUSIONS Suicide riskwas highest on Mondays and increased on New Year's Day in most countries. However, the risk of suicide on weekends and Christmas varied by country and territory. The results of this study can help to better understand the short term variations in suicide risks and define suicide prevention action plans and awareness campaigns.
Rainfall events and daily mortality across 645 global locations: two stage time series analysis
(2024) HE, Cheng; BREITNER-BUSCH, Susanne; HUBER, Veronika; CHEN, Kai; ZHANG, Siqi; GASPARRINI, Antonio; BELL, Michelle; KAN, Haidong; ROYE, Dominic; ARMSTRONG, Ben; SCHWARTZ, Joel; SERA, Francesco; VICEDO-CABRERA, Ana Maria; HONDA, Yasushi; JAAKKOLA, Jouni J. K.; RYTI, Niilo; KYSELY, Jan; GUO, Yuming; TONG, Shilu; DE'DONATO, Francesca; MICHELOZZI, Paola; COELHO, Micheline de Sousa Zanotti Stagliorio; SALDIVA, Paulo Hilario Nascimento; LAVIGNE, Eric; ORRU, Hans; INDERMITTE, Ene; PASCAL, Mathilde; GOODMAN, Patrick; ZEKA, Ariana; KIM, Yoonhee; DIAZ, Magali Hurtado; ARELLANO, Eunice Elizabeth Felix; OVERCENCO, Ala; KLOMPMAKER, Jochem; RAO, Shilpa; PALOMARES, Alfonso Diz-Lois; CARRASCO, Gabriel; SEPOSO, Xerxes; SILVA, Susana das Neves Pereira da; MADUREIRA, Joana; HOLOBACA, Iulian-Horia; SCOVRONICK, Noah; ACQUAOTTA, Fiorella; KIM, Ho; LEE, Whanhee; HASHIZUME, Masahiro; TOBIAS, Aurelio; INIGUEZ, Carmen; FORSBERG, Bertil; RAGETTLI, Martina S.; GUO, Yue Leon; PAN, Shih-Chun; OSORIO, Samuel; LI, Shanshan; ZANOBETTI, Antonella; DANG, Tran Ngoc; DUNG, Do Van; SCHNEIDER, Alexandra
Objective: To examine the associations between characteristics of daily rainfall (intensity, duration, and frequency) and all cause, cardiovascular, and respiratory mortality. Design: Two stage time series analysis. Setting: 645 locations across 34 countries or regions. Population: Daily mortality data, comprising a total of 109 954 744 all cause, 31 164 161 cardiovascular, and 11 817 278 respiratory deaths from 1980 to 2020. Main outcome measure: Association between daily mortality and rainfall events with return periods (the expected average time between occurrences of an extreme event of a certain magnitude) of one year, two years, and five years, with a 14 day lag period. A continuous relative intensity index was used to generate intensity-response curves to estimate mortality risks at a global scale. Results: During the study period, a total of 50 913 rainfall events with a one year return period, 8362 events with a two year return period, and 3301 events with a five year return period were identified. A day of extreme rainfall with a five year return period was significantly associated with increased daily all cause, cardiovascular, and respiratory mortality, with cumulative relative risks across 0-14 lag days of 1.08 (95% confidence interval 1.05 to 1.11), 1.05 (1.02 to 1.08), and 1.29 (1.19 to 1.39), respectively. Rainfall events with a two year return period were associated with respiratory mortality only, whereas no significant associations were found for events with a one year return period. Non-linear analysis revealed protective effects (relative risk <1) with moderate-heavy rainfall events, shifting to adverse effects (relative risk >1) with extreme intensities. Additionally, mortality risks from extreme rainfall events appeared to be modified by climate type, baseline variability in rainfall, and vegetation coverage, whereas the moderating effects of population density and income level were not significant. Locations with lower variability of baseline rainfall or scarce vegetation coverage showed higher risks. Conclusion: Daily rainfall intensity is associated with varying health effects, with extreme events linked to an increasing relative risk for all cause, cardiovascular, and respiratory mortality. The observed associations varied with local climate and urban infrastructure.
2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
(2024) MARTIN, Seth S.; ADAY, Aaron W.; ALMARZOOQ, Zaid I.; ANDERSON, Cheryl A. M.; ARORA, Pankaj; AVERY, Christy L.; BAKER-SMITH, Carissa M.; GIBBS, Bethany Barone; BEATON, Andrea Z.; BOEHME, Amelia K.; COMMODORE-MENSAH, Yvonne; CURRIE, Maria E.; ELKIND, Mitchell S. V.; EVENSON, Kelly R.; GENEROSO, Giuliano; HEARD, Debra G.; HIREMATH, Swapnil; JOHANSEN, Michelle C.; KALANI, Rizwan; KAZI, Dhruv S.; KO, Darae; LIU, Junxiu; MAGNANI, Jared W.; MICHOS, Erin D.; MUSSOLINO, Michael E.; NAVANEETHAN, Sankar D.; PARIKH, Nisha I.; PERMAN, Sarah M.; POUDEL, Remy; REZK-HANNA, Mary; ROTH, Gregory A.; SHAH, Nilay S.; ST-ONGE, Marie-Pierre; THACKER, Evan L.; TSAO, Connie W.; URBUT, Sarah M.; SPALL, Harriette G. C. Van; VOEKS, Jenifer H.; WANG, Nae-Yuh; WONG, Nathan D.; WONG, Sally S.; YAFFE, Kristine; PALANIAPPAN, Latha P.
BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health. The AHA Heart Disease and Stroke Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, brain health, complications of pregnancy, kidney disease, congenital heart disease, rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary heart disease, cardiomyopathy, heart failure, valvular disease, venous thromboembolism, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2024 AHA Statistical Update is the product of a full year's worth of effort in 2023 by dedicated volunteer clinicians and scientists, committed government professionals, and AHA staff members. The AHA strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year's edition includes additional global data, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.