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Chemical compound
Lidoflazine![](//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Lidoflazine.png/220px-Lidoflazine.png) |
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AHFS/Drugs.com | International Drug Names |
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ATC code | |
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2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
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CAS Number | |
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PubChem CID | |
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ChemSpider | |
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UNII | |
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KEGG | |
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CompTox Dashboard (EPA) | |
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ECHA InfoCard | 100.020.285 ![Edit this at Wikidata](//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png) |
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Formula | C30H35F2N3O |
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Molar mass | 491.627 g·mol−1 |
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3D model (JSmol) | |
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Melting point | 159 to 161 °C (318 to 322 °F) |
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Solubility in water | Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C) |
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CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
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InChI=1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36) NKey:ZBIAKUMOEKILTF-UHFFFAOYSA-N N
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N Y (what is this?) (verify) |
Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.
Physical properties
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Solubility at room temperature
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Extracted from[1]
Solvent
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0.01
N
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0.1
N
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%
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pH
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%
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pH
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Hydrochloric Acid
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0.4
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3.0
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0.7
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1.9
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Tartaric Acid
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0.3
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3.1
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1.0
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2.5
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Citric Acid
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0.3
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3.1
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0.5
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2.5
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Lactic Acid
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0.2
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3.4
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0.7
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2.9
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Acetic Acid
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0.1
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3.5
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0.4
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3.8
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- Schaper WK, Xhonneux R, Jageneau AH (November 1965). "Stimulation of the coronary collateral circulation by lidoflazine (R 7904)". Naunyn-Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie. 252 (1): 1–8. doi:10.1007/bf00246424. PMID 4222721. S2CID 31959581.
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Calcium | VDCCsTooltip Voltage-dependent calcium channels | |
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Potassium | VGKCsTooltip Voltage-gated potassium channels | |
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IRKsTooltip Inwardly rectifying potassium channel | |
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KCaTooltip Calcium-activated potassium channel | |
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K2PsTooltip Tandem pore domain potassium channel | |
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Sodium | VGSCsTooltip Voltage-gated sodium channels | |
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ENaCTooltip Epithelial sodium channel | |
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ASICsTooltip Acid-sensing ion channel | |
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Chloride | CaCCsTooltip Calcium-activated chloride channel | |
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CFTRTooltip Cystic fibrosis transmembrane conductance regulator | |
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Unsorted | |
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Others | TRPsTooltip Transient receptor potential channels | |
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LGICsTooltip Ligand gated ion channels | |
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Simple piperazines (no additional rings) | |
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Phenylpiperazines |
- 2C-B-PP
- 3,4-CFP
- Acaprazine
- Antrafenine
- Aripiprazole
- Batoprazine
- Bifeprunox
- BRL-15,572
- Ciprofloxacin
- CSP-2503
- Dapiprazole
- DCPP
- DMPP
- Diphenylpiperazine
- Dropropizine
- EGIS-12,233
- Elopiprazole
- Eltoprazine
- Enpiprazole
- Ensaculin
- Etoperidone
- Flesinoxan
- Fluanisone
- Flibanserin
- Fluprazine
- Itraconazole
- Ketoconazole
- Levodropropizine
- Lorpiprazole
- mCPP
- Mefway
- MeOPP
- Mepiprazole
- Naftopidil
- Naluzotan
- Naphthylpiperazine
- Nefazodone
- Niaprazine
- Oxypertine
- Pardoprunox
- pCPP
- pFPP
- Posaconazole
- S-14,506
- S-14,671
- S-15,535
- SB-258,585
- SB-271,046
- SB-357,134
- SB-399,885
- Sonepiprazole
- TFMPP
- Tolpiprazole
- Trazodone
- Urapidil
- Vesnarinone
- Vilazodone
- Vortioxetine
- WAY-100,135
- WAY-100,635
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Benzylpiperazines | |
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Diphenylalkylpiperazines (benzhydrylalkylpiperazines) | |
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Pyrimidinylpiperazines | |
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Pyridinylpiperazines | |
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Benzo(iso)thiazolylpiperazines | |
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Tricyclics (piperazine attached via side chain) | |
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Others/Uncategorized | |
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[1]