Bencyclane
Appearance
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Names | |
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IUPAC name
3-[(1-benzylcycloheptyl)oxy]-N,N-dimethylpropan-1-amine
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.016.861 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C19H31NO | |
Molar mass | 289.45554 |
Pharmacology | |
C04AX11 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Bencyclane is an antispasmodic, vasodilator, and platelet aggregation inhibitor.[1]
Synthesis
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/b/b2/Bencyclane_synthesis.svg/500px-Bencyclane_synthesis.svg.png)
Grignard addition of benzylmagnesiumbromide to suberone would give 1-benzylcycloheptanol [4006-73-9] (1'). Williamson ether synthesis with 3-dimethylaminopropylchloride [109-54-6] (2) completed the synthesis of bencyclane (3).
See also
[edit]References
[edit]- ^ J. Elks, ed. (2014). The Dictionary of Drugs: Chemical Data, Structures and Bibliographies. Springer.
- ^ Pallos, L.; Budai, Z.; Zólyomi, G. (1972). "Basic ethers of 1-substituted cycloalkanols. 1". Arzneimittel-Forschung. 22 (9): 1502–1505. PMID 4678613.
- ^ Pallos, L.; Budai, Z.; Zólyomi, G. (1972). "Basic ethers of 1-substituted cycloalkanols. 2". Arzneimittel-Forschung. 22 (9): 1505–1509. PMID 4678614.
- ^ Anon., ES 376120 (1972-04-01 to Gallardo Antonio SA).
- ^ Spaeter Genannt Werden Wird, DE 2455051A1 (1975 to Andreu S A Lab).