MCF2

MCF2
식별자
에일리어스	MCF2, ARHGEF21, DBL, MCF.2 셀 회선 유도 변환 시퀀스
외부 ID	OMIM: 311030 MGI: 96932 HomoloGene: 3917 GeneCard: MCF2
유전자 위치(마우스)
크르.	X염색체(쥐)
끝.	59,224,449 bp
RNA발현패턴
	상단 표시 위치:
	정낭포; ; 내피 세포; ; 브로드만 23구역; ; 시상하부; ; 브로드만 9구역; ; 전전두피질; ; 흑색 실체; ; 핀; ; 중측두회; ; 핵액컴벤스;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	GO:0001948 단백질 결합; 구아닐-플루오르화물교환인자활성;
셀룰러 컴포넌트	세포질; 세포; 세포골격; 막;
생물학적 과정	Rho단백질신호전달조절; GO:0007243 세포내 신호 전달; 소량 GTPase 매개 신호 전달 조절; 아포토시스 과정의 양성 조절; G단백질결합수용체신호경로; 축삭 형성의 음성 조절; 수상돌기의 발달; 백혈병 억제 인자에 대한 세포 반응;
	출처:아미고 / QuickGO
맞춤법
	4168
	109904
	없음
	ENSMUSG000031139
	P10911
	없음
NM_001099855; NM_001171876; NM_001171877; NM_001171878; NM_001171879;
	NM_005369
NM_001289730; NM_001289731; NM_133197; NM_001358998; NM_001358999;
	NM_001359000; NM_001359001
NP_001093325; NP_001165347; NP_001165348; NP_001165349; NP_001165350;
	NP_005360
	없음
	위키데이터
인간 보기/편집	마우스 표시/편집

DBL 원종 유전자는 MCF2 유전자에 ^[4]^[5]^[6]의해 인간에게 암호화되는 단백질이다.

일반적으로 사용되는 DBL이라는 이름은 이 유전자가 종양 ^[7]유전자로 처음 확인된 암 유형인 "확산 B 세포 림프종"에서 유래한 것이며, MCF2라는 이름은 "MCF.2 세포주 유래 변환 배열"^[8]에서 유래했다.

DBL은 공통 DBL-호몰로지(DH) 도메인을 공유하는 구아닌 뉴클레오티드 교환 인자의 큰 패밀리의 창립 멤버이다. 따라서 DBL은 또한 ARHGEF21로 이 Rho 패밀리의 멤버로 명명된다. DH 도메인은 비활성 GDP로부터의 방출을 촉진하여 Rho 패밀리의 작은 GTPases를 활성화하는 기능을 한다.특히 DBL은 Rho 패밀리 멤버 Cdc42를 ^[9]활성화한다.

N 말단 영역의 손실을 초래하는 유전자 재조합은 발암 활성을 가진 MCF2 변형을 생성한다.[OMIM ^[6]제공]

레퍼런스

^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000031139 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D (December 1988). "Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences". Oncogene. 3 (6): 709–15. PMID 2577874.
^ Galland F, Stefanova M, Lafage M, Birnbaum D (Jul 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.
^ ^a ^b "Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence".
^ Eva A, Aaronson SA (1985-07-18). "Isolation of a new human oncogene from a diffuse B-cell lymphoma". Nature. 316 (6025): 273–5. Bibcode:1985Natur.316..273E. doi:10.1038/316273a0. PMID 3875039. S2CID 4268140.
^ Noguchi T, Mattei MG, Oberlè I, Planche J, Imbert J, Pelassy C, et al. (May 1987). "Localization of the mcf.2 transforming sequence to the X chromosome". The EMBO Journal. 6 (5): 1301–7. doi:10.1002/j.1460-2075.1987.tb02368.x. PMC 553933. PMID 3038515.
^ Fort P, Blangy A (June 2017). "The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals". Genome Biology and Evolution. 9 (6): 1471–1486. doi:10.1093/gbe/evx100. PMC 5499878. PMID 28541439.

추가 정보

Ron D, Zannini M, Lewis M, Wickner RB, Hunt LT, Graziani G, et al. (April 1991). "A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr". The New Biologist. 3 (4): 372–9. PMID 2065022.
Tronick SR, McBride OW, Popescu NC, Eva A (October 1989). "Chromosomal localization of DBL oncogene sequences". Genomics. 5 (3): 546–53. doi:10.1016/0888-7543(89)90022-0. PMID 2613238.
Ron D, Tronick SR, Aaronson SA, Eva A (August 1988). "Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells". The EMBO Journal. 7 (8): 2465–73. doi:10.1002/j.1460-2075.1988.tb03093.x. PMC 457116. PMID 3056717.
Eva A, Vecchio G, Rao CD, Tronick SR, Aaronson SA (April 1988). "The predicted DBL oncogene product defines a distinct class of transforming proteins". Proceedings of the National Academy of Sciences of the United States of America. 85 (7): 2061–5. Bibcode:1988PNAS...85.2061E. doi:10.1073/pnas.85.7.2061. PMC 279928. PMID 3281159.
Srivastava SK, Wheelock RH, Aaronson SA, Eva A (December 1986). "Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene". Proceedings of the National Academy of Sciences of the United States of America. 83 (23): 8868–72. Bibcode:1986PNAS...83.8868S. doi:10.1073/pnas.83.23.8868. PMC 387034. PMID 3491366.
Hart MJ, Eva A, Zangrilli D, Aaronson SA, Evans T, Cerione RA, Zheng Y (January 1994). "Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product". The Journal of Biological Chemistry. 269 (1): 62–5. doi:10.1016/S0021-9258(17)42313-1. PMID 8276860.
Nishida K, Kaziro Y, Satoh T (October 1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits". FEBS Letters. 459 (2): 186–90. doi:10.1016/S0014-5793(99)01244-2. PMID 10518015. S2CID 83524892.
Kato J, Kaziro Y, Satoh T (February 2000). "Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation". Biochemical and Biophysical Research Communications. 268 (1): 141–7. doi:10.1006/bbrc.2000.2106. PMID 10652228.
Zhu K, Debreceni B, Li R, Zheng Y (August 2000). "Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation". The Journal of Biological Chemistry. 275 (34): 25993–6001. doi:10.1074/jbc.M003780200. PMID 10854437.
Palmieri G, de Franciscis V, Casamassimi A, Romano G, Torino A, Pingitore P, et al. (July 2000). "Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site". Gene. 253 (1): 107–15. doi:10.1016/S0378-1119(00)00212-2. PMID 10925207.
Jin S, Exton JH (November 2000). "Activation of RhoA by association of Galpha(13) with Dbl". Biochemical and Biophysical Research Communications. 277 (3): 718–21. doi:10.1006/bbrc.2000.3744. PMID 11062019.
Zhu K, Debreceni B, Bi F, Zheng Y (January 2001). "Oligomerization of DH domain is essential for Dbl-induced transformation". Molecular and Cellular Biology. 21 (2): 425–37. doi:10.1128/MCB.21.2.425-437.2001. PMC 86589. PMID 11134331.
Vanni C, Mancini P, Gao Y, Ottaviano C, Guo F, Salani B, et al. (May 2002). "Regulation of proto-Dbl by intracellular membrane targeting and protein stability". The Journal of Biological Chemistry. 277 (22): 19745–53. doi:10.1074/jbc.M111025200. PMID 11907027.
Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (December 2002). "RhoG signals in parallel with Rac1 and Cdc42". The Journal of Biological Chemistry. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
Komai K, Okayama R, Kitagawa M, Yagi H, Chihara K, Shiozawa S (December 2002). "Alternative splicing variants of the human DBL (MCF-2) proto-oncogene". Biochemical and Biophysical Research Communications. 299 (3): 455–8. doi:10.1016/S0006-291X(02)02645-1. PMID 12445822.
Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S (October 2003). "Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene" (PDF). Biochemical and Biophysical Research Communications. 309 (4): 906–9. doi:10.1016/j.bbrc.2003.08.088. PMID 13679059.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

인간 X 염색체 및/또는 그와 관련된 단백질의 유전자에 대한 이 기사는 스텁이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCm38Ensembl-1] GRCm38: 앙상블 릴리즈 89: ENSMUSG000031139 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2577874-4] Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D (December 1988). "Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences". Oncogene. 3 (6): 709–15. PMID 2577874.

[pmid1611909-5] Galland F, Stefanova M, Lafage M, Birnbaum D (Jul 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.

[entrez-6] "Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence".

[pmid3875039-7] Eva A, Aaronson SA (1985-07-18). "Isolation of a new human oncogene from a diffuse B-cell lymphoma". Nature. 316 (6025): 273–5. Bibcode:1985Natur.316..273E. doi:10.1038/316273a0. PMID 3875039. S2CID 4268140.

[pmid3038515-8] Noguchi T, Mattei MG, Oberlè I, Planche J, Imbert J, Pelassy C, et al. (May 1987). "Localization of the mcf.2 transforming sequence to the X chromosome". The EMBO Journal. 6 (5): 1301–7. doi:10.1002/j.1460-2075.1987.tb02368.x. PMC 553933. PMID 3038515.

[pmid28541439-9] Fort P, Blangy A (June 2017). "The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals". Genome Biology and Evolution. 9 (6): 1471–1486. doi:10.1093/gbe/evx100. PMC 5499878. PMID 28541439.

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