Transient receptor potential cation channel subfamily M member 2 (Q7671477)

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mammalian protein found in Homo sapiens

transient receptor potential cation channel subfamily M member 2
TRPM2
long transient receptor potential channel 2
transient receptor potential channel 7
LTrpC2
LTrpC-2
transient receptor potential melastatin 2
TrpC7
estrogen-responsive element-associated gene 1 protein

Language	Label	Description	Also known as
English	Transient receptor potential cation channel subfamily M member 2	mammalian protein found in Homo sapiens	transient receptor potential cation channel subfamily M member 2 TRPM2 long transient receptor potential channel 2 transient receptor potential channel 7 LTrpC2 LTrpC-2 transient receptor potential melastatin 2 TrpC7 estrogen-responsive element-associated gene 1 protein

Statements

1 reference

13 November 2019

UniProt protein ID

NUDIX hydrolase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O94759

Transient receptor potential cation channel subfamily M member 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O94759

transient receptor potential channel

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

NUDIX hydrolase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ion transport domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

sodium channel activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

ion channel activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

calcium ion binding

determination method or standard

1 reference

16 July 2018

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O94759&geneProductId=UniProtKB:O94759

determination method or standard

calcium-release channel activity

determination method or standard

1 reference

8 April 2019

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

ligand-gated calcium channel activity

determination method or standard

6 references

8 April 2019

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Structures and gating mechanism of human TRPM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Functional characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

calcium ion binding

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

ADP-ribose diphosphatase activity

determination method or standard

1 reference

8 April 2019

Structures and gating mechanism of human TRPM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

mono-ADP-D-ribose binding

determination method or standard

1 reference

8 April 2019

Structures and gating mechanism of human TRPM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

lysosomal membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

integral component of plasma membrane

determination method or standard

3 references

16 July 2018

Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain

http://www.ebi.ac.uk/QuickGO/annotations?protein=O94759&geneProductId=UniProtKB:O94759

determination method or standard

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O94759&geneProductId=UniProtKB:O94759

determination method or standard

16 July 2018

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O94759&geneProductId=UniProtKB:O94759

determination method or standard

cytoplasmic vesicle membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

cytoplasmic vesicle

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

specific granule membrane

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

cell projection

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

tertiary granule membrane

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

ficolin-1-rich granule membrane

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

plasma membrane

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

integral component of plasma membrane

determination method or standard

4 references

8 April 2019

Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Structures and gating mechanism of human TRPM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

biological process

sodium ion transmembrane transport

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

sodium ion transport

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

cation transport

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

response to oxidative stress

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

ion transmembrane transport

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

transmembrane transport

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

temperature homeostasis

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

dendritic cell chemotaxis

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

response to purine-containing compound

determination method or standard

1 reference

8 April 2019

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

calcium-mediated signaling using intracellular calcium source

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

neutrophil degranulation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

release of sequestered calcium ion into cytosol

determination method or standard

regulation of filopodium assembly

determination method or standard

1 reference

8 April 2019

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

cellular response to hydrogen peroxide

determination method or standard

1 reference

8 April 2019

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

cellular response to calcium ion

determination method or standard

1 reference

8 April 2019

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

cellular response to purine-containing compound

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

cellular response to temperature stimulus

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

zinc ion transmembrane transport

determination method or standard

1 reference

8 April 2019

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

dendritic cell differentiation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

calcium ion transmembrane import into cytosol

determination method or standard

2 references

8 April 2019

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

regulation of actin cytoskeleton reorganization

determination method or standard

1 reference

8 April 2019

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

calcium ion import across plasma membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

protein homotetramerization

determination method or standard

1 reference

8 April 2019

Structures and gating mechanism of human TRPM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

calcium ion transmembrane transport

determination method or standard

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Structures and gating mechanism of human TRPM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

8 April 2019

Functional characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

determination method or standard

physically interacts with

cyclic ADP-ribose

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

hydrogen peroxide

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

arachidonic acid

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

2-aminoethoxydiphenylborate

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

flufenamic acid

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Ion transport domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O94759

NUDIX hydrolase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O94759

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000300481

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000300481

ENSP00000300482

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000300482

ENSP00000381023

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000381023

ENSP00000381026

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000381026

ENSP00000393982

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000393982

ENSP00000477514

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477514

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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