Transient receptor potential cation channel subfamily C member 6 (Q7671469)

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mammalian protein found in Homo sapiens

focal segmental glomerulosclerosis 2
transient receptor protein 6
short transient receptor potential channel 6
TRP-6
TRPC6

Language	Label	Description	Also known as
English	Transient receptor potential cation channel subfamily C member 6	mammalian protein found in Homo sapiens	focal segmental glomerulosclerosis 2 transient receptor protein 6 short transient receptor potential channel 6 TRP-6 TRPC6

Statements

1 reference

13 November 2019

UniProt protein ID

transient receptor potential channel

1 reference

Transporter Classification Database ID

30 September 2019

based on heuristic

hierarchical database ID heuristic

Ankyrin repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y210

transient receptor potential channel, canonical 6

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y210

transient receptor potential channel

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Ion transport domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

actinin binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

clathrin binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

inositol 1,4,5 trisphosphate binding

determination method or standard

1 reference

24 April 2018

Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y210&geneProductId=UniProtKB:Q9Y210

determination method or standard

protein binding

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

calcium channel activity

determination method or standard

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y210&geneProductId=UniProtKB:Q9Y210

determination method or standard

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y210&geneProductId=UniProtKB:Q9Y210

determination method or standard

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y210&geneProductId=UniProtKB:Q9Y210

determination method or standard

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y210&geneProductId=UniProtKB:Q9Y210

determination method or standard

cation channel activity

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

A novel TRPC6 mutation that causes childhood FSGS.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

protein homodimerization activity

determination method or standard

1 reference

8 April 2019

New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

inositol 1,4,5 trisphosphate binding

determination method or standard

calcium channel activity

determination method or standard

3 references

determination method or standard

1 reference

8 April 2019

SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

plasma membrane

determination method or standard

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

cation channel complex

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

biological process

regulation of cytosolic calcium ion concentration

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

positive regulation of cytosolic calcium ion concentration

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

cation transport

determination method or standard

1 reference

8 April 2019

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

single fertilization

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

platelet activation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

positive regulation of ion transmembrane transporter activity

determination method or standard

1 reference

8 April 2019

Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

negative regulation of dendrite morphogenesis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

positive regulation of peptidyl-threonine phosphorylation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

calcium ion transmembrane transport

determination method or standard

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y210&geneProductId=UniProtKB:Q9Y210

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y210&geneProductId=UniProtKB:Q9Y210

determination method or standard

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y210&geneProductId=UniProtKB:Q9Y210

determination method or standard

positive regulation of neuron differentiation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

neuron differentiation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

manganese ion transport

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

cellular response to hypoxia

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

calcium ion transport

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

cellular response to hydrogen peroxide

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

positive regulation of calcium ion transport

determination method or standard

1 reference

8 April 2019

Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

transmembrane transport

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

calcium ion transmembrane transport

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y210

determination method or standard

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

arachidonic acid

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

2-aminoethoxydiphenylborate

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000353687

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353687

ENSP00000340913

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000340913

ENSP00000343672

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000343672

ENSP00000435574

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435574

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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