The DNA damage response: putting checkpoints in perspective (Q28131713)

Radiosensitivity in ataxia-telangiectasia: a new explanation

Europe PubMed Central

title

The DNA damage response: putting checkpoints in perspective (English)

0 references

0 references

B B Zhou

1

0 references

S J Elledge

series ordinal

2

0 references

language of work or name

English

0 references

publication date

23 November 2000

0 references

published in

Nature

0 references

volume

408

0 references

issue

6811

0 references

page(s)

433-9

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

ATM-dependent phosphorylation of nibrin in response to radiation exposure

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Cell cycle checkpoints: preventing an identity crisis

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Circular chromosome formation in a fission yeast mutant defective in two ATM homologues

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Hypothesis: Ataxia‐telangiectasia: Is ATM a sensor of oxidative damage and stress?

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

MEC1-dependent phosphorylation of Rad9p in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

The FHA domain is a modular phosphopeptide recognition motif.

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Structure and function of a new phosphopeptide-binding domain containing the FHA2 of Rad53

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

The G2-phase DNA-damage checkpoint

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Rfc5, a Replication Factor C Component, Is Required for Regulation of Rad53 Protein Kinase in the Yeast Checkpoint Pathway

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

A novel Rad24 checkpoint protein complex closely related to replication factor C.

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Substrate specificities and identification of putative substrates of ATM kinase family members

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Atm-deficient mice: a paradigm of ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

ATM associates with and phosphorylates p53: mapping the region of interaction

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Regulation of p53 function and stability by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Checkpoint Pathways Come of Age

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Principles of CDK regulation

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Global response of Saccharomyces cerevisiae to an alkylating agent

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Brca1 controls homology-directed DNA repair

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

Yeast checkpoint genes in DNA damage processing: implications for repair and arrest

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

1 reference

https://api.crossref.org/works/10.1038%2F35044005

7 January 2021

https://api.crossref.org/works/10.1038%2F35044005

1 reference

7 January 2021