The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement (Q24683336)

4

object named as

Parviz Minoo

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author name string

Keziban Unsal-Kaçmaz

1

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Paul D Chastain

2

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Ping-Ping Qu

3

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Marila Cordeiro-Stone

5

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William K Kaufmann

Molecular and Cellular Biology

7

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language of work or name

English

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publication date

April 2007

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published in

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volume

27

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issue

8

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page(s)

3131-42

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cites work

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Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint

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Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

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Coupling of human circadian and cell cycles by the timeless protein

7 April 2017

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Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

7 April 2017

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Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

7 April 2017

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hRAD30 mutations in the variant form of xeroderma pigmentosum

7 April 2017

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RPA involvement in the damage-recognition and incision steps of nucleotide excision repair

7 April 2017

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Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA

7 April 2017

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The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae

7 April 2017

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Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.

7 April 2017

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Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.

7 April 2017

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Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.

7 April 2017

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Identification of protein complexes required for efficient sister chromatid cohesion

7 April 2017

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The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

7 April 2017

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Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

7 April 2017

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

7 April 2017

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Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation

7 April 2017

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Human claspin is required for replication checkpoint control

7 April 2017

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An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

7 April 2017

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Regulation of cellular and SV40 virus origins of replication by Chk1-dependent intrinsic and UVC radiation-induced checkpoints

7 April 2017

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Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae

7 April 2017

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Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors

7 April 2017

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Timeless in lung morphogenesis

7 April 2017

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Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association

7 April 2017

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TopBP1 activates the ATR-ATRIP complex

7 April 2017

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The DNA replication checkpoint response stabilizes stalled replication forks

7 April 2017

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Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

7 April 2017

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The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism

7 April 2017

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Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis

28 September 2017

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Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

28 September 2017

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Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences

28 September 2017

1 reference

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Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties

28 September 2017

1 reference

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Spatio-temporal organization of DNA replication in murine embryonic stem, primary, and immortalized cells.

28 September 2017

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swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe

28 September 2017

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Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.

28 September 2017

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Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage

28 September 2017

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Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1.

28 September 2017

1 reference

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An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage

28 September 2017

1 reference

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Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

28 September 2017

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

28 September 2017

1 reference

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Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells

28 September 2017

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Overexpression and purification of human XPA using a baculovirus expression system

28 September 2017

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Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand

28 September 2017

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Spatial distributions of early and late replicating chromatin in interphase chromosome territories

28 September 2017

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Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

28 September 2017

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DNA damage and cell cycle checkpoints

28 September 2017

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Differential replication of a single, UV-induced lesion in the leading or lagging strand by a human cell extract: fork uncoupling or gap formation

28 September 2017

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Cell cycle control, DNA repair and initiation of carcinogenesis.

28 September 2017

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The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm

28 September 2017

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Radiosensitivity in ataxia-telangiectasia: a new explanation

28 September 2017

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Structure of the replication fork in ultraviolet light-irradiated human cells

28 September 2017

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G1 arrest and cell-cycle-dependent clastogenesis in UV-irradiated human fibroblasts.

28 September 2017

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Excision repair of UV- or benzo[a]pyrene diol epoxide-induced lesions in xeroderma pigmentosum variant cells is 'error free'.

30 May 2018

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Checkpoint regulation of replication dynamics in UV-irradiated human cells.

30 May 2018

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Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex

28 November 2018

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The role of DNA polymerase eta in translesion synthesis past platinum-DNA adducts in human fibroblasts

28 November 2018

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Visualization of altered replication dynamics after DNA damage in human cells

28 November 2018

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Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage

28 November 2018

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Enhanced expression of X-ray- and UV-induced chromosome aberrations by cytosine arabinoside in ataxia telangiectasia cells

28 November 2018

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12 December 2020

DNA double labelling with IdUrd and CldUrd for spatial and temporal analysis of cell proliferation and DNA replication

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12 December 2020

Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV Lesions

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12 December 2020

Mechanisms of inhibition of DNA replication by ultraviolet light in normal human and xeroderma pigmentosum fibroblasts

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12 December 2020