Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 (Q15317485)

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mammalian protein found in Mus musculus
  • DNA-binding factor KBF1
  • nuclear factor NF-kappa-B p105 subunit
  • NF-kappa-B1 p84/NF-kappa-B1 p98
  • Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • p50 subunit of NF kappaB
  • EBP-1
  • NF-kappaB p50
  • nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
  • NF kappaB1
  • Nfkb1
  • nuclear factor kappaB p50
edit
Language Label Description Also known as
English
Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
mammalian protein found in Mus musculus
  • DNA-binding factor KBF1
  • nuclear factor NF-kappa-B p105 subunit
  • NF-kappa-B1 p84/NF-kappa-B1 p98
  • Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • p50 subunit of NF kappaB
  • EBP-1
  • NF-kappaB p50
  • nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
  • NF kappaB1
  • Nfkb1
  • nuclear factor kappaB p50

Statements

part of
molecular function
protein binding
determination method or standard
IPI
7 references
retrieved
14 February 2019
stated in
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IPI
retrieved
14 February 2019
stated in
IkappaBeta, a nuclear IkappaB protein, positively regulates the NF-kappaB-mediated expression of proinflammatory cytokines
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IPI
retrieved
14 February 2019
stated in
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IPI
retrieved
14 February 2019
stated in
Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IPI
retrieved
14 February 2019
stated in
Consequences of IkappaB alpha hydroxylation by the factor inhibiting HIF (FIH)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IPI
retrieved
14 February 2019
stated in
Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IPI
retrieved
14 February 2019
stated in
Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IPI
DNA binding
determination method or standard
IDA
IEA
ISO
11 references
retrieved
14 February 2019
stated in
JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IEA
retrieved
14 February 2019
stated in
Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
cell component
nucleus
determination method or standard
IDA
IEA
ISO
14 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IEA
retrieved
14 February 2019
stated in
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Regulation of mature T lymphocyte proliferation and differentiation by Par-4
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
biological process
positive regulation of transcription by RNA polymerase II
determination method or standard
IDA
IEA
IMP
ISO
5 references
retrieved
14 February 2019
stated in
The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
ISO
retrieved
14 February 2019
stated in
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IMP
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IEA
retrieved
14 February 2019
stated in
Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA
retrieved
14 February 2019
stated in
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25799
determination method or standard
IDA

Identifiers

PDB structure ID
 
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