Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A γδ T cell–IL-3 signalling axis is defined that controls the allergen responsiveness of cutaneous sensory neurons, leading to evidence for an immune rheostat that governs sensory neuronal responses to allergens on first exposure.
Precision functional mapping shows that the frontostriatal salience network occupies nearly twice as much of the cortex in people with depression, and this was unaffected by mood changes and detected in children before onset of symptoms.
A global macroplastic pollution emissions inventory and methodology is developed using machine learning and probabilistic material flow analysis, to identify hotspots across more than 50,000 municipalities worldwide from five land-based plastic waste emission sources.
Rapid ocean deoxygenation during the Early Cretaceous OAE1a is shown to provide evidence for a strong link between volcanic CO2 emissions, weathering and ocean oxygen content that is characterized by a climate threshold.
Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses in cisgender individuals.
Signatures of magnetism control by the flow of angular momentum are observed in Pt/Al/Fe/GaAs(001) multilayers by the application of an in-plane charge current in Pt.
A vacuum ultraviolet frequency comb is used to directly excite the narrow 229Th nuclear clock transition in a solid-state CaF2 host material, marking the start of nuclear-based solid-state optical clocks.
Observations of gravitational instability in the disk around AB Aurigae using deep observations of 13CO and C18O line emission provide evidence that giant protoplanets can be formed from collapsing fragments of vast spiral arms.
CD8+ T cell–macrophage interactions have a central role in impairing alveolar regeneration and driving fibrotic sequelae after acute viral pneumonia in a mouse model of long COVID.
A polymer-like ultrahigh-strength TiNi alloy was fabricated by a simple three-step process to give a combination of a polymer-like ultralow elastic modulus and a steel-like ultrahigh yield strength over a wide temperature range, and such exotic properties arise from a unique strain glass state.
Single-cell analysis of the transcriptome, chromatin accessibility and methylome of adult neural stem cells and astrocytes demonstrates that stemness is driven by methylation profiles distinct from those of astrocytes.
Analysis of 43,191 genomes obtained from publicly available marine bacterial and archaeal metagenome data provides insights into marine bacterial evolution, CRISPR–Cas defence and antibiotic resistance genes, and demonstrates the potential of marine metagenomes for biotechnological applications.
Re-exposure to a high-fat diet in mice led to emergency myelopoiesis and increased neutrophils in the blood, which infiltrated plaques and released neutrophil extracellular traps, exacerbating atherosclerosis.
The authors use lineage tracing to map the fate of wild-type and Brca1−/−;Trp53−/− cells in the adult mouse mammary gland, identifying three layers of protection that limit the spread of mutant cells at the expense of allowing a minority of mutant cells to expand, which leads to field cancerization.
Structural studies of a homodimeric arrangement of hepatitis C virus envelope E1/E2 heterodimers reveals the molecular basis of intracomplex interactions and provides mechanistic insights into neutralizing antibody evasion and membrane fusion with host cells.