Search Results (6,126)

As the world pivots to a greener paradigm, Shanghai emerges as an archetype in the sustainable urban transit narrative, particularly through the aggressive expansion and refinement of its electric vehicle (EV) charging infrastructure. This scholarly article provides a comprehensive examination of the current state of charging infrastructure in Shanghai, highlighting the challenges that the existing infrastructure may face in light of the burgeoning electric vehicle market. This paper delves into the strategic development approaches adopted by Shanghai to address these challenges, particularly emphasizing the expansion of high-power charging infrastructure to meet the anticipated increase in future electric vehicle charging demands. It also discusses the implementation of co-construction and sharing models, the enhancement of interconnectivity and standardized management of charging facilities, and the continuous improvement and strengthening of infrastructure construction and operations. Furthermore, this article explores the implementation of time-of-use electricity pricing policies and the ongoing conduct of demand response activities, which are instrumental in creating conditions for vehicle-to-grid interaction. The aim of our presentation is to foster a keen understanding among policymakers, industry stakeholders, and urban planners of the mechanisms necessary to effectively navigate the emerging electric vehicle market, thereby encouraging harmonious development between metropolises and transportation systems. Future research endeavors should delve into the realms of fast-charging technologies, intelligent operation and maintenance of charging infrastructure, and vehicle-to-grid interaction technologies. These areas of study are pivotal in fostering the harmonious development of electric vehicles (EVs) and their charging infrastructure, thereby aligning with the dual objectives of advancing urban transportation systems and sustainable green city development. The findings presented herein offer valuable insights for policymakers, urban planners, and industry leaders, guiding them in crafting informed strategies that not only address the immediate needs of the EV market but also lay the groundwork for a scalable and resilient charging infrastructure, poised to support the long-term vision of sustainable urban mobility. Full article

Thirty-seven steroid drugs of different types were investigated in silico for their environmental and pharmacokinetic properties (partition between soil and water, bioaccumulation in aquatic organisms, ability to be absorbed from the gastrointestinal tract and to cross biological barriers—skin, blood–brain barrier and placenta) using on-line tools and novel QSAR models. The same drugs were studied by Molecular Docking in the context of their ability to interact with two enzymes—glutathione S-transferase (GST) and human N-acetyltransferase 2 (NAT2), which are involved in the placenta’s protective system against harmful xenobiotics. Steroid drugs are released to the environment from households, hospitals, manufacturing plants and farms (e.g., with natural fertilizers) and they can affect the aquatic life (reproduction and development of aquatic organisms), even at sub-ng/L concentrations. It was established that the majority of studied drugs are mobile in soil, so they may reach surface waters far from point of discharge, e.g., from farming; however, only a few of them are likely to bioaccumulate. All of them can be absorbed orally or through skin, and they are also expected to cross the placenta. Over 30% of studied compounds are likely to pass through the blood–brain barrier (although five compounds in this group are likely P-gp substrates, which may reduce their activity in the central nervous systems); they have also very high affinity for both studied enzymes. Full article

Background: Sprengel’s Deformity (SD) is a rare condition of the shoulder girdle, appearing as the principal congenital anomaly of the shoulder in paediatric patients. The aim of this study is to document the combined experience of two paediatric orthopaedic departments in managing SD using the modified Green Procedure, with a specific emphasis on the clinical and functional outcomes reported by patients; Methods: from June 2010 to February 2023, 42 shoulders in 40 paediatric patients were surgically treated for SD at two paediatric orthopaedic departments. All patients were treated using the modified Green Procedure with or without clavicle osteotomy. To better evaluate the deformity, the Cavendish’s classification for aesthetic appearance and the Rigault’s classification for radiological aspect were used, while movements of abduction and flexion were quantified to assess shoulder mobility. Several dedicated questionnaires such as QuickDASH, the Shoulder Pain Index and the Shoulder Disability Index (SPADI) and finally the UCLA Shoulder Scale were submitted to assess the quality of life of the subjects and the ability to practice certain activities, including work and sports. Complications were evaluated according to the modified Clavien–Dindo–Sink classification; Results: The mean follow-up was 5 years (range, 1.0–13.6). Clavicular osteotomy, performed in 15 patients, improved post-operative abduction by a mean of 25° (95% CI: 11–39°; p = 0.001). Three patients had complications (7.1%), with two requiring re-operation. At follow-up, 67.5% of patients had a qDASH score < 7, highlighting excellent functional outcomes. Shoulder function showed moderate correlation with pre- and post-operative flexion. The SPADI and UCLASS scores indicated significant improvement, with 70.0% reporting high satisfaction. Factors like sex, associated anomalies, and surgical technique did not impact patient-reported outcomes or satisfaction; Conclusions: The modified Green’s technique has proven to be a safe procedure with a low rate of complications and satisfactory clinical and functional patient-reported outcomes. Full article

Objectives: To summarize the impact of various telerehabilitation interventions on motor function, balance, gait, activities of daily living (ADLs), and quality of life (QoL) among patients with stroke and to determine the existing telerehabilitation interventions for delivering physiotherapy sessions in clinical practice. Methods: Six electronic databases were searched to identify relevant quantitative systematic reviews (SRs). Due to substantial heterogeneity, the data were analysed narratively. Results: A total of 28 systematic reviews (n = 245 primary studies) were included that examined various telerehabilitation interventions after stroke. Motor function was the most studied outcome domain across the reviews (20 SRs), followed by ADL (18 SRs), and balance (14 SRs) domains. For primary outcomes, our findings highlight moderate- to high-quality evidence showing either a significant effect or no significant difference between telerehabilitation and other interventions. There was insufficient evidence to draw a conclusion regarding feasibility outcomes, including participant satisfaction, adherence to treatment, and cost. Most reviews under this umbrella included patients with stroke in the subacute or chronic phase (12 SRs). Simple and complex telerehabilitation interventions such as telephone calls, videoconferencing, smartphone- or tablet-based mobile health applications, messaging, virtual reality, robot-assisted devices, and 3D animation videos, either alone or in combination with other interventions, were included across reviews. Conclusions: Various telerehabilitation interventions have shown either a significant effect or no significant difference compared to other interventions in improving upper and lower limb motor function, balance, gait, ADLs, and QoL, regardless of whether simple or complex approaches were used. Further research is needed to support the delivery of rehabilitation services through telerehabilitation intervention following a stroke. Full article

Synthetic peptides are commonly obtained by means of solid-phase peptide synthesis (SPPS), in which separation of the peptide from the solid support requires treatment with 92.5% v/v trifluoroacetic acid (TFA); therefore, peptides are obtained as trifluoroacetate salts. For promising anticancer/antibacterial peptides it is essential to exchange the counterion from trifluoroacetate to hydrochloride or acetate, since the former are more widely studied in biological activity assays. In this research, RP-SPE-based methodologies were designed, developed, and implemented for simultaneous counterion exchange and peptide purification. Critical process steps were identified and parameters such as mobile phase composition, elution, and program were optimized. Analysis of the counterion exchange reaction and characterization of the final products was performed using high-performance liquid chromatography, attenuated total reflectance, nuclear magnetic resonance, and mass spectrometry. Peptides with purities between 82–97% and a trifluoroacetate ion content less than 0.36% were obtained. This novel counterion exchange proved efficient for peptides with different characteristics such as length, polarity, polyvalency, and presence of non-natural amino acids or non-protein molecules, therefore showing a wide range of applications in the field of therapeutic peptides. The methods developed are fast, efficient, low-cost, and do not require robust instrumentation and can be routinely implemented in SPPS. Full article

In recent years, research on older prisoners in England and Wales has expanded significantly, and the term “older prisoner” is now well entrenched in the prison-based literature. Those prisoners who are over the age of 50 are now the fastest growing demographic in the prison system and they present with a wide range of specific health and social care needs. This paper provides an overview of the main challenges facing older prisoners in the context of their health and social care needs, including the development of mental health problems such as Alzheimer’s and dementia, as well as challenges related to mobility and engaging in structured activities in prison. This paper also considers the issue of dying in prison for older prisoners as well as the challenges of resettlement and reintegration post-release. Full article

Accurate localisation is key for the autonomy of mobile robots. Fiducial localisation utilises relative positions of markers physically deployed across an environment to determine a localisation estimate for a robot. Fiducial markers are strictly designed, with very limited flexibility in appearance. This often results in a “trade-off” between visual customisation, library size, and occlusion resilience. Many fiducial localisation approaches vary in their position estimation over time, leading to instability. The Stable Fiducial Marker System (STag) was designed to address this limitation with the use of a two-stage homography detection. Through its combined square and circle detection phases, it can refine detection stability. In this work, we explore the utility of STag as a basis for a stable mobile robot localisation system. Key marker restrictions are addressed in this work through contributions of three new chromatic STag marker types. The hue/greyscale STag marker set addresses constraints in customisability, the high-capacity STag marker set addresses limitations in library size, and the high-occlusion STag marker set improves resilience to occlusions. These are designed with compatibility with the STag detection system, requiring only preprocessing steps for enhanced detection. They are assessed against the existing STag markers and each shows clear improvements. Further, we explore the viability of various materials for marker fabrication, for use in outdoor and low-light conditions. This includes the exploration of “active” materials which induce effects such as retro-reflectance and photo-luminescence. Detection rates are experimentally assessed across lighting conditions, with “active” markers assessed on the practicality of their effects. To encapsulate this work, we have developed a full end-to-end deployment for fiducial localisation under the STag system. It is shown to function for both on-board and off-board localisation, with deployment in practical robot trials. As a part of this contribution, the associated software for marker set generation/detection, physical marker fabrication, and end-to-end localisation has been released as an open source distribution. Full article

Risk communication from the perspective of Extreme Event Attribution (EEA), which assesses the extent to which climate change influences various extreme weather events, has significant potential for climate change communication due to its ability to make the phenomenon more relatable to citizens. This study examines the digital conversation generated following the wave of wildfires in Spain in 2022, which was declared the worst year of the 21st century in terms of hectares burned. By using the Social Network Analysis (SNA) methodology, 145,081 tweets were analyzed to construct a mention network, capturing the digital clusters formed around this discussion and highlighting the predominant tones in the debate. The findings reveal that the conversation predominantly adopted a tone of outrage and assigned responsibility. This research study offers a renewed perspective on risk communication, highlighting significant challenges faced by environmental activism on social media and underscoring the need to improve communication strategies to increase awareness and mobilization around climate change. Full article

Mobility digital twins (MDTs), which utilize multi-modal microscopic (micro) traffic simulations and an activity-based demand generation, are envisioned as flexible and reliable planning tools for addressing today’s increasingly complex and diverse transport scenarios. Hybrid models may become a resource-efficient solution for building MDTs by creating large-scale, mesoscopic (meso) traffic simulations, using simplified, queue-based network-link models, in combination with more detailed local micro-traffic simulations focused on areas of interest. The overall objective of this paper is to develop an efficient toolchain capable of automatically generating, calibrating, and validating hybrid scenarios, with the following specific goals: (i) an automated and seamless merge of the meso- and micro-networks and demand; (ii) a validation procedure that incorporates real-world data into the hybrid model, enabling the meso- and micro-sub-models to be validated separately and compared to determine which simulation, micro- or meso-, more accurately reflects reality. The developed toolchain is implemented and applied to a case study of Munich, Germany, with the micro-simulation focusing on the city quarter of Schwabing, using real-word traffic flow and floating car data for validation. When validating the simulated flows with the detected flows, the regression curve shows acceptable values. The speed validation with floating car data reveals significant differences; however, it demonstrates that the micro-simulation achieves considerably better agreement with real speeds compared to the meso-model, as expected. Full article

Diabetes mellitus (DM) is a global health concern with a rising incidence, particularly in aging populations and those with a genetic predisposition. Over time, DM contributes to various complications, including nephropathy, retinopathy, peripheral arterial disease (PAD), and neuropathy. Among these, diabetic neuropathy and PAD stand out due to their high prevalence and significant impact on patients’ quality of life. Diabetic distal symmetric polyneuropathy, the most common form of diabetic neuropathy, is driven by neuroinflammation stemming from prolonged hyperglycemia. Simultaneously, hyperglycemia significantly increases the risk of PAD, a condition further exacerbated by factors like smoking, age, and sedentary lifestyles. PAD frequently manifests as claudication, a debilitating symptom marked by pain and cramping during physical activity, which limits mobility and worsens patients’ outcomes. Cilostazol, a phosphodiesterase-3 inhibitor, has proven effective in managing intermittent claudication in PAD by improving walking distances and enhancing blood flow. Recent studies have also explored its potential benefits for diabetic neuropathy. Cilostazol’s mechanisms include vasodilation, platelet inhibition, and increased cyclic adenosine monophosphate (cAMP) levels, which may contribute to improved neurological outcomes. However, variability in the clinical evidence due to inconsistent treatment protocols highlights the need for further investigation. This review explores cilostazol’s mechanisms of action and therapeutic applications for managing neuropathy and PAD in diabetic patients, aiming to provide insights into its potential as a dual-purpose pharmacological agent in this high-risk population. Full article

The self-contained breathing apparatus (SCBA) is an integral part of the structural firefighting personal protective equipment (PPE) ensemble. However, when donned, it adds significant weight and restriction, interfering with the fit of the turnout suit and the ventilation within the clothing system. This may result in a reduction of air gaps within the clothing microclimate, quickening the onset of heat strain. Therefore, the purpose of this study was to assess the impact of the SCBA on air gaps in structural firefighting turnout suits. Nine active-duty male firefighter participants were scanned in a three-dimensional body scanner in four garment configurations (compression, base layers, turnout suit, and turnout with SCBA). Torso volume, surface area, and air gaps were calculated alongside ease measurements. Findings demonstrated a 59% increase in torso volume when donning the turnout suit over base layers compared to a 1.2% reduction in torso volume when donning the SCBA. The change in torso air gap volume and distance were also found to be negligible when donning the SCBA. This study lays the foundation for full systems ensemble research needed to better understand how the design, weight, and fit of the SCBA impacts the thermal comfort, mobility, and protection of structural firefighters. Full article

Colorectal cancer (CRC) is often associated with metastasis and recurrence and is the leading cause of cancer-related mortality. In the progression of CRC, recent studies have highlighted the critical role of neutrophils, particularly tumor-associated neutrophils (TANs). TANs have both tumor-promoting and tumor-suppressing activities, contributing to metastasis, immunosuppression, angiogenesis, and epithelial-to-mesenchymal transition. Tumor-promoting TANs promote tumor growth by releasing proteases, reactive oxygen species, and cytokines, whereas tumor-suppressing TANs enhance immune responses by activating T cells and natural killer cells. Understanding the mechanisms underlying TAN mobilization, plasticity, and their role in the tumor microenvironment has revealed potential therapeutic targets. This review provides a comprehensive overview of TAN biology in CRC and discusses both the tumor-promoting and tumor-suppressing functions of neutrophils. Novel therapeutic approaches targeting TANs, such as chemokine receptor antagonists, aim to modulate neutrophil reprogramming and offer promising avenues for improving treatment outcomes of CRC. Full article

This study focuses on understanding the health impacts of hazardous air pollutant (HAP) emissions from the Kaohsiung Coastal Industrial Park and port areas in southern Taiwan on neighboring communities. Six important HAPs (formaldehyde, benzene, arsenic, vinyl chloride, 1,3-butadiene, and diesel particulate matter (DPM)) were identified in this area. By considering the impact of emissions from stationary sources, mobile sources, and port activities, the relative importance of each emission source was assessed. In addition, the AERMOD (AMS (American Meteorological Society)/EPA (U.S. Environmental Protection Agency)) diffusion model was employed to simulate the increases in target pollutant concentrations and to analyze the influence and spatial distribution of various emission sources on atmospheric HAP concentrations in nearby communities. This study further evaluated the exposure risks of composite HAP sources, to understand their impacts and to determine their control priorities. The findings revealed that emissions and carcinogenic weighting from composite sources, particularly DPM emissions from port activities, including from ocean-going vessels and heavy-duty vehicles, had a significant impact. The maximum incremental concentration for DPM in the study area occurred around the port area, whereas the maxima for formaldehyde, benzene, arsenic, vinyl chloride, and 1,3-butadiene were all observed within the industrial complex. DPM emissions from port activities, 1,3-butadiene emissions from mobile sources, and benzene emissions from stationary sources were the composite sources with the greatest potential impacts. Over 90% of health risks were due to DPM, and the remaining health risks were due to 1,3-butadiene (6%), benzene (2%), arsenic (1%), and other species (less than 1%). DPM emissions were primarily influenced by port activities (77%), 1,3-butadiene emissions by mobile sources (45%), and benzene emissions by stationary sources (41%). A total of 25% of the area had risk values greater than 10⁻³, and 75% of the area had risk values between 10⁻³ and 10⁻⁴. The risk values in the densely populated areas were all greater than 10⁻⁴. The potential risk hotspots with risk values greater than 10⁻³ were located on the northwest side of the port and downwind of the industrial park. The key pollutants contributing to these hotspots were, in order, DPM (up to 80% cancer risk), formaldehyde, and 1,3-butadiene, all of which were significantly influenced by port activities. This indicates that the control of, and reduction in, HAP emissions from port activities should be prioritized. Full article

The increasing use of unmanned aerial vehicles (UAVs) in the commercial and recreational sectors has led to a heightened demand for effective recovery solutions after a crash, particularly for lightweight drones. This paper presents the development of a long-range and low-cost emergency radio beacon designed specifically for small UAVs. Unlike traditional emergency locator transmitters (ELTs), our proposed beacon addresses the unique needs of UAVs by reducing size, weight, and cost, while maximizing range and power efficiency. The device utilizes a global system for mobile (GSM)-based communication module to transmit location data via short message service (SMS), eliminating the need for specialized receivers and expanding the operational range even in obstacle-rich environments. Additionally, a built-in global navigation satellite system (GNSS) receiver provides precise coordinates, activated only upon impact detection through an accelerometer, thereby saving power during normal operations. Experimental tests confirm the extended range, high precision, and compatibility of the prototype with common mobile networks. Cost-effective and easy to use, this beacon improves UAV recovery efforts by providing reliable localization data to users in real time, thus safeguarding the UAV investment. Full article

The solvent-free hydrogenolysis (HDL) of benzyl phenyl ether (BPE), a model for the C–O (α-O-4) linkage in lignin, was investigated using NiMo-pillared clay catalysts in their reduced (NiMoPR) and sulfided (NiMoPS) forms. NiMoPS show higher activity and selectivity to give an equimolar mixture of toluene and phenol, demonstrating selective cleavage of the C_aliphatic–O of BPE, while non-equimolar amounts were found for NiMoPR. Strong acid sites are dominant in NiMoPS, giving a higher total acidity compared to NiMoPR, which explains the higher selectivity of the sulfided catalyst towards the HDL products and monomeric aromatics. To understand the interaction of BPE on the catalyst surface, we carried out a comprehensive investigation of the 2D potential energy surface (PES) of BPE and the vibrational spectra using neutron scattering and computational studies. The results suggest that BPE is weakly adsorbed on NiMoPS and the pillared clay support (PILC) via a van der Waals or H-bonding interaction, but they are strongly chemisorbed on the NiMoPR due to covalent bonding. Weakly adsorbed BPE allows higher mobility during diffusion to the catalytic site, which promotes the higher activity of NiMoPS for the HDL. This work demonstrates the potential use of clay-supported NiMo catalysts for lignin valorization and the future circular economy. Full article