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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Treatment Strategies for Prostate Cancer: An Update submission deadline 25 Sep 2025 | Viewed by 12 | Submission Open
Keywords: prostate cancer; robotic surgery; uro-oncology; focal therapy; single-port; radiotherapy
(This special issue belongs to the Section Nephrology & Urology)
Clinical Developments of Oral and Maxillofacial Surgery submission deadline 25 Sep 2025 | Viewed by 12 | Submission Open
Keywords: oral surgery; maxillofacial surgery; bone resorption; implant surgery; oral rehabilitation
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Diagnosis and Surgical Treatment for Colorectal Cancer
edited by Nidal Issa, Wisam Khoury and Rachel Gingold-Belfer
submission deadline 25 Sep 2025 | Viewed by 8 | Submission Open
Keywords: colorectal cancer; laparoscopy; colonoscopy; colectomy; diagnosis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Post-Return of Spontaneous Circulation (Post-ROSC) Management for Out-of-Hospital Cardiac Arrest (OHCA) Patients: What We Can Do to Improve Survival and Return to Work and Participation in Society?
edited by
submission deadline 25 Sep 2025 | Viewed by 3 | Submission Open
Keywords: return of spontaneous circulation (ROSC); quality of life; psychological distress; post-ROSC management; return to society
(This special issue belongs to the Section Cardiology)
Cardiac Surgery: Clinical Advances
edited by Carmelo Dominici, Giovanni Casali and
submission deadline 25 Sep 2025 | Viewed by 3 | Submission Open
Keywords: cardiac surgery; surgical innovation; minimally invasive techniques; robotic surgery; personalized medicine; advanced surgical technologies
(This special issue belongs to the Section Cardiology)
Clinical Application of Artificial Intelligence in Vascular Surgery
edited by
submission deadline 25 Sep 2025 | Submission Open
Keywords: artificial intelligence; machine learning; vision; vascular imaging; natural language processing; innovation; vascular surgery; vascular diseases; endovascular; aortic disease; carotid disease; peripheral artery disease; venous disease
(This special issue belongs to the Section Vascular Medicine)
Clinical Progress in Microsurgical Reconstruction: 2nd Edition
edited by
submission deadline 25 Sep 2025 | Submission Open
Keywords: microsurgery; supermicrosurgery; microvascular anastomosis; head and neck reconstruction; oro-maxillofacial re-construction; plastic and reconstructive surgery; limb reconstruction; breast reconstruction; genital reconstruc-tion; lymphedema; lymph nodes transfer; facial reanimation
(This special issue belongs to the Section General Surgery)
Clinical Advances and Challenges in Laparoscopic Surgery
edited by Leonid Barkhatov
submission deadline 25 Sep 2025 | Submission Open
Keywords: laparoscopic surgery; minimally invasive surgery; surgical outcomes; oncologic surgery; general surgery; learning curve
(This special issue belongs to the Section General Surgery)
Current Progress in the Treatment of Cornea and Ocular Surface Diseases
edited by Marco Messina and
submission deadline 28 Sep 2025 | Viewed by 37 | Submission Open
Keywords: dry eye disease; meibomian gland dysfunction; microbial keratitis; auto-immune keratitis; peripheral ulcerative keratitis; neurotrophic keratopathy; corneal dystrophies; corneal degenerations; mucous membrane pemphigoid; ocular cicatricial disease; Stevens– Johnson syndrome; pterygium; ocular graft-versus-host disease; limbal stem cell deficiency; keratoplasty; amniotic membrane transplantation; keratoconus; corneal collagen cross-linking; antimicrobial therapy; corneal neurotization; vernal keratoconjunctivitis; atopic keratoconjunctivitis
(This special issue belongs to the Section Ophthalmology)
New Advances in COVID-19 and Pregnancy
edited by
submission deadline 30 Sep 2025 | 10 articles | Viewed by 13298 | Submission Open
Keywords: COVID-19 and pregnancy; SARS-CoV-2 infection; maternal mortality and morbidity; pregnancy complication; management protocol; maternal comorbidities; severe disease; prevention; diagnosis; treatment; management
(This special issue belongs to the Section Obstetrics & Gynecology)
Gynecological Cancers: Surgical Treatment and Novel Radiotherapy
edited by
submission deadline 30 Sep 2025 | 5 articles | Viewed by 9267 | Submission Open
Keywords: gynecological cancers; uterine cancer; cervical cancer; vulvar cancer; biomarkers; fertility preservation; sentinel lymph node evaluation; fertility-sparing treatment; novel treatment strategies
(This special issue belongs to the Section Obstetrics & Gynecology)
Experience and New Application in Otolaryngology and Maxillofacial Surgery
edited by Riccardo Nocini
submission deadline 30 Sep 2025 | 1 articles | Viewed by 460 | Submission Open
Keywords: new surgical techniques; robotics; endoscopy; revascularized free flaps; innovation; 3D surgical planning.
(This special issue belongs to the Section Otolaryngology)
Improving Diagnosis and Treatment of Vestibular Disorder: Latest Advances and Challenges
edited by , and Athanasia Korda
submission deadline 30 Sep 2025 | Viewed by 368 | Submission Open
Keywords: vestibular system; balance disorders; dizziness; vertigo; vestibular testing; videonystagmography; video head impulse test; vestibular evoked myogenic potentials; vestibular rehabilitation therapy
(This special issue belongs to the Section Otolaryngology)
Multiple Sclerosis and Demyelinating Diseases: Diagnosis, Treatment and Prognosis
edited by Alberto Gajofatto
submission deadline 30 Sep 2025 | Viewed by 167 | Submission Open
Keywords: multiple sclerosis; neuromyelitis optica; MOG-antibody disease; diagnosis; prognosis; treatment
(This special issue belongs to the Section Clinical Neurology)
Hepatobiliary and Pancreatic (HPB) Surgery: Current Status and Future Perspectives
edited by Andrea Benedetti Cacciaguerra and Paolo Vincenzi
submission deadline 30 Sep 2025 | Viewed by 52 | Submission Open
Keywords: hepatobiliary and pancreatic surgery; laparoscopic surgery; robot-assisted surgery; artificial intelligence; augmented reality; indocyanine green; liver tumors; pancreatic tumors
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Modern Approaches to the Management of Orthopedic Injuries
edited by
submission deadline 30 Sep 2025 | Viewed by 37 | Submission Open
Keywords: orthopedic trauma; surgical integration; trauma management; modern approaches; rehabilitation advances
(This special issue belongs to the Section Orthopedics)
Management of Inflammatory Bowel Disease: A Multidisciplinary Perspective submission deadline 30 Sep 2025 | Viewed by 32 | Submission Open
Keywords: inflammatory bowel disease management; Crohn's disease; ulcerative colitis; patient-centered care; multidisciplinary management; personalized treatment
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
COVID-19 and Endocrine Complications
edited by
submission deadline 30 Sep 2025 | Viewed by 30 | Submission Open
Keywords: adrenal; ACE2; diabetes; gonads; pituitary; SARS-CoV-2; thyroid
(This special issue belongs to the Section Endocrinology & Metabolism)
Advancements in Venous Disease Management: From Conservative to Interventional Treatments
edited by and Chiara Lomazzi
submission deadline 30 Sep 2025 | Viewed by 29 | Submission Open
Keywords: chronic venous disease; varicose veins; venoactive drugs; saphenous vein; venous stent; iliac vein; compression therapy; venous insufficiency
(This special issue belongs to the Section Vascular Medicine)
Targeted Diagnosis and Treatment of Coronary Artery Disease: 2nd Edition
edited by
submission deadline 30 Sep 2025 | Viewed by 28 | Submission Open
Keywords: coronary artery disease; myocardial revascularization; percutaneous coronary intervention; cardiac surgery; coronary artery bypass graft; intravascular ultrasound; fractional flow reserve; instantaneous wave-free ratio; angiogenesis
(This special issue belongs to the Section Cardiology)
Innovative Approaches to Upper Limb Rehabilitation in Orthopaedics: Advances in Functional Recovery and Pain Management
edited by and Danilo Donati
submission deadline 30 Sep 2025 | Viewed by 27 | Submission Open
Keywords: upper limb rehabilitation; orthopaedics; musculoskeletal disorders; functional recovery; pain management
(This special issue belongs to the Section Orthopedics)
Thrombosis and Haemostasis: Clinical Advances
edited by Hui Yin Lim
submission deadline 30 Sep 2025 | Viewed by 25 | Submission Open
Keywords: venous thrombosis; biomarkers; bleeding; direct oral anticoagulants; pulmonary embolism; factor XI inhibitors; factor XII inhibitors; endovascular treatment
(This special issue belongs to the Section Vascular Medicine)
Esophageal and Upper Interventional Endoscopy and Surgery: Latest Advances and Prospects
edited by Giulia Gibiino
submission deadline 30 Sep 2025 | Viewed by 24 | Submission Open
Keywords: gastric preneoplastic and neoplastic lesions; endoscopic submucosal dissection (ESD); endoscopic full-thickness resection (EFTR); subepithelial upper GI lesions; duodenal adenomas; esophageal stenting
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Multidisciplinary Approach to the Diagnosis and Treatment of Temporomandibular Disorders: Patient Care Challenges—2nd Edition submission deadline 30 Sep 2025 | Viewed by 19 | Submission Open
Keywords: multidisciplinary approach; mental health; bruxism; masticatory muscles; temporomandibular joint; orofacial pain; temporomandibular disorders
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Innovations in Head and Neck Surgery
edited by and Giovanni Badiali
submission deadline 30 Sep 2025 | Viewed by 14 | Submission Open
Keywords: reconstructive surgery; head and neck surgery; 3D printing; new technologies; virtual surgical planning; computer-assisted surgery; personalized reconstructive surgery; patient-specific implants; augmented reality; artificial intelligence; robotic surgery; surgical navigation
(This special issue belongs to the Section Otolaryngology)
Clinical Diagnosis and Therapeutic Approaches for Acute and Chronic Coronary Syndromes
edited by Rocco Antonio Montone
submission deadline 30 Sep 2025 | Viewed by 14 | Submission Open
Keywords: coronary artery disease; clinical diagnosis; therapeutic approaches; atherosclerosis; risk factors; percutaneous cor-onary intervention; acute coronary syndrome; MINOCA; INOCA
(This special issue belongs to the Section Cardiology)
Minimally Invasive Evolutions in Advanced Oncologic Visceral Surgery
edited by
submission deadline 30 Sep 2025 | Viewed by 12 | Submission Open
Keywords: minimally invasive; oncologic surgery; robotic; laparoscopic; outcome
(This special issue belongs to the Section Oncology)
Pediatric Sleep-Disordered Breathing
edited by Audrey Yoon
submission deadline 30 Sep 2025 | Viewed by 10 | Submission Open
Keywords: pediatric sleep-disordered breathing; growth modification; pediatric obstructive sleep apnea; interdisciplinary management; craniofacial development; obstructive sleep disorders; cognitive behavioral sleep medicine; pediatric dental sleep medicine; pediatric sleep surgery
(This special issue belongs to the Section Clinical Pediatrics)
Modern Concepts on Acoustic Neuroma
edited by Alessia Rubini and Davide Soloperto
submission deadline 30 Sep 2025 | Viewed by 9 | Submission Open
Keywords: neurotology; neurosurgery; vestibular schwannoma; acoustic neuroma; middle cranial fossa approach; retrosigmoid approach; translabirynthine approach; gammaknife; wait and scan policy
(This special issue belongs to the Section Otolaryngology)
Breast Cancer: Advances in Clinical and Personalized Practices
edited by Massimo Lodi and Sébastien Molière
submission deadline 30 Sep 2025 | Viewed by 9 | Submission Open
Keywords: breast cancer; radiology; surgical oncology; breast reconstruction; personalized medicine; quality of life; multidisci-plinary approach; new technologies
(This special issue belongs to the Section Oncology)
New Progress in Pediatric Orthopedics and Pediatric Spine Surgery
edited by
submission deadline 30 Sep 2025 | Submission Open
Keywords: pediatric spine; scoliosis; clubfoot; flatfoot; developmental dysplasia of the hip; rare diseases
(This special issue belongs to the Section Clinical Pediatrics)
Systemic Autoimmune Disorder with Pulmonary Involvement: Novel Insights from Underlying Mechanisms of Drug Development and Intervention
edited by
submission deadline 30 Sep 2025 | Submission Open
Keywords: rheumatic diseases; pulmonary involvement; connective tissue disorders; systemic autoimmune disorders (SARDs); diagnosis; innovative treatments
(This special issue belongs to the Section Pulmonology)
Latest Advances in Thoracic Surgery: 2nd Edition
edited by
submission deadline 30 Sep 2025 | Submission Open
Keywords: lung cancer; surgical oncology; robotic surgery; thoracic surgery; lung diseases; minimally invasive surgery
(This special issue belongs to the Section Pulmonology)
New Advances in Musculoskeletal Physiotherapy: Exercise, Manual Therapy and Invasive Physiotherapy
edited by and Ignacio Cancela-Cilleruelo
submission deadline 30 Sep 2025 | Submission Open
Keywords: musculoskeletal disorders; exercise therapy; manual therapy; invasive physical therapy; rehabilitation
(This special issue belongs to the Section Orthopedics)
Endovascular Surgery: State of the Art and Clinical Perspectives
edited by Andrea Xodo and Francesco Squizzato
submission deadline 9 Oct 2025 | Viewed by 11 | Submission Open
Keywords: complex aortic endovascular repair; aortic arch endovascular surgery; endoleaks; PMEG; spinal cord ischemia; endograft-related adverse events
(This special issue belongs to the Section Vascular Medicine)
Chronic Kidney Disease Management: Integrating Pharmacotherapy, Biomarkers, and Lifestyle Interventions for Improved Outcomes
edited by
submission deadline 15 Oct 2025 | Viewed by 31 | Submission Open
Keywords: nephrology; chronic kidney disease; cardiovascular risk; risk stratification; biomarkers; evidence-based treatment
(This special issue belongs to the Section Nephrology & Urology)
Testicular Cancer: Clinical Advances in Diagnosis and Treatment
edited by , Andreas Maxeiner and
submission deadline 25 Oct 2025 | Viewed by 27 | Submission Open
Keywords: testicular cancer; ultrasound imaging; computed tomography; new imaging modalities; personalized medicine; oncology; surgical treatment
(This special issue belongs to the Section Oncology)
Clinical Update on Thoracic Trauma
edited by
submission deadline 30 Oct 2025 | Submission Open
Keywords: flail chest; isolated sternal fractures; manubrio-sternal dislocation; pneumothorax; hemothorax; thoracic aortic injury; heart and pulmonary vessels lesion; intercostal artery injury; diaphragm rupture; thoracoabdominal hernia; chylothorax; esophageal perforation
Advances in the Diagnosis and Treatment of Skin Cancer submission deadline 31 Oct 2025 | Viewed by 44 | Submission Open
Keywords: skin cancer; melanoma; keratinocyte carcinoma; basal cell carcinoma; squamous cell carcinoma; biomarkers; immuno-therapy; prognosis
(This special issue belongs to the Section Oncology)
Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care
edited by
submission deadline 30 Nov 2025 | Viewed by 12 | Submission Open
Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging
(This special issue belongs to the Section Cardiology)
Cerebral Palsy: Recent Advances in Clinical Management
edited by Laurie J. Glader and M. Wade Shrader
submission deadline 30 Dec 2025 | Viewed by 241 | Submission Open
Keywords: cerebral palsy; pediatric; neurology; complex care; clinical management
(This special issue belongs to the Section Clinical Pediatrics)
Interdisciplinary Approach on the Oral Cavity Management Due to Musculoskeletal Conditions
edited by Cosmin Sinescu, and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 6426 | Submission Open
Keywords: rehabilitation medicine; biomechanics; bruxism assessment; general medicine; dental medicine; biomedical imaging; musculoskeletal disorders; shoulder girdle; cervical region; physical therapy; therapeutic exercise; postural correction; dynamic balance; pediatric rehabilitation; sports medicine; quality of life research; general conditions with resonance in the oro-maxillo-facial sphere
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
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