TUBGCP2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | TUBGCP2 , GCP-2, GCP2, Grip103, SPBC97, Spc97p, h103p, hGCP2, hSpc97, tubulin gamma complex associated protein 2, ALP4, SPC97, PAMDDFS | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 617817 MGI: 1921487 HomoloGene: 55980 GeneCards: TUBGCP2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene. [5] [6] It is part of the gamma-tubulin complex, which is required for microtubule nucleation at the centrosome.
Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily. α- and β-tubulins polymerize into microtubules, a major component of the eukaryotic cytoskeleton. Microtubules function in many essential cellular processes, including mitosis. Tubulin-binding drugs kill cancerous cells by inhibiting microtubule dynamics, which are required for DNA segregation and therefore cell division.
Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.
Tubulin beta-4B chain formerly known as tubulin beta-2C chain is a protein that in humans is encoded by the TUBB4B gene.
Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.
Tubulin alpha-8 chain is a protein that in humans is encoded by the TUBA8 gene.
Tubulin alpha-1C chain is a protein that in humans is encoded by the TUBA1C gene.
Tubulin-folding cofactor B is a protein that in humans is encoded by the TBCB gene.
Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene.
Gamma-tubulin complex component 3 is a protein that in humans is encoded by the TUBGCP3 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.
Gamma-tubulin complex component 5 is a protein that in humans is encoded by the TUBGCP5 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.
Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene. The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.
Gamma-tubulin complex component 6 is a protein that in humans is encoded by the TUBGCP6 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.
Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene and encodes the protein NEDD1.
Dystrobrevin beta is a protein which in humans is encoded by the DTNB gene.
Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. It is the homolog of the C. elegans and D. melanogaster gene SPD-2.
Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene. Its function appears two be twofold: CEP164 is required for primary cilium formation. Furthermore, it is an important component in the response to DNA damage by UV light.
Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene.
Centrosomal protein of 78 kDa, also known as Cep78, is a protein that in humans is encoded by the CEP78 gene.
Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene. It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.
Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.