TNP2

TNP2
Identifiers
Aliases	TNP2 , TP2, transition protein 2 (during histone to protamine replacement), transition protein 2
External IDs	OMIM: 190232 HomoloGene: 3958 GeneCards: TNP2
Gene location (Human)
Chr.	Chromosome 16 (human)
End	11,269,533 bp
RNA expression pattern
	Top expressed in
	sperm; ; right coronary artery; ; human musculoskeletal system; ; muscular system; ; muscle; ; muscle; ; prefrontal cortex; ; male reproductive gland; ; prostate; ; connective tissue;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding ; metal ion binding ; zinc ion binding ;
Cellular component	male germ cell nucleus ; nucleosome ; nucleus ; chromosome ;
Biological process	multicellular organism development ; cell differentiation ; spermatogenesis ; acrosome reaction ; penetration of zona pellucida ; positive regulation of protein processing ;
	Sources:Amigo / QuickGO
Orthologs
	7142
	n/a
	ENSG00000178279
	n/a
	Q05952
	n/a
	NM_005425
	n/a
	NP_005416
	n/a
	Wikidata
View/Edit Human

Last updated December 04, 2023

Nuclear transition protein 2 is a protein that in humans is encoded by the TNP2 gene.^[3]^[4]^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178279 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Engel W, Keime S, Kremling H, Hameister H, Schluter G (Nov 1992). "The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome". Cytogenet Cell Genet. 61 (2): 158–9. doi:10.1159/000133397. PMID 1395729.
↑ Baskaran R, Rao MR (Jan 1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1". J Biol Chem. 265 (34): 21039–47. doi: 10.1016/S0021-9258(17)45324-5 . PMID 2250010.
↑ "Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement)".

Schlüter G, Kremling H, Engel W (1992). "The gene for human transition protein 2: nucleotide sequence, assignment to the protamine gene cluster, and evidence for its low expression". Genomics. 14 (2): 377–83. doi:10.1016/S0888-7543(05)80229-0. PMID 1385303.
Kundu TK, Rao MR (1995). "DNA condensation by the rat spermatidal protein TP2 shows GC-rich sequence preference and is zinc dependent". Biochemistry. 34 (15): 5143–50. doi:10.1021/bi00015a027. PMID 7711033.
Nelson JE, Krawetz SA (1995). "Characterization of a human locus in transition". J. Biol. Chem. 269 (49): 31067–73. doi: 10.1016/S0021-9258(18)47391-7 . PMID 7983046.
Nelson JE, Krawetz SA (1993). "Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the P1-->P2-->TP2 locus". J. Biol. Chem. 268 (4): 2932–6. doi: 10.1016/S0021-9258(18)53863-1 . PMID 8428967.
Kundu TK, Rao MR (1997). "Zinc dependent recognition of a human CpG island sequence by the mammalian spermatidal protein TP2". Biochemistry. 35 (49): 15626–32. doi:10.1021/bi961271i. PMID 8961924.
Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
Wyckoff GJ, Wang W, Wu CI (2000). "Rapid evolution of male reproductive genes in the descent of man". Nature. 403 (6767): 304–9. Bibcode:2000Natur.403..304W. doi:10.1038/35002070. PMID 10659848. S2CID 3136139.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Wykes SM, Krawetz SA (2003). "The structural organization of sperm chromatin". J. Biol. Chem. 278 (32): 29471–7. doi: 10.1074/jbc.M304545200 . PMID 12775710.
Miyagawa Y, Nishimura H, Tsujimura A, et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations". J. Androl. 26 (6): 779–86. doi: 10.2164/jandrol.05069 . PMID 16291974.
Jedrzejczak P, Kempisty B, Bryja A, et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044. S2CID 21999596.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000178279 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1395729-3] Engel W, Keime S, Kremling H, Hameister H, Schluter G (Nov 1992). "The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome". Cytogenet Cell Genet. 61 (2): 158–9. doi:10.1159/000133397. PMID 1395729.

[pmid2250010-4] Baskaran R, Rao MR (Jan 1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1". J Biol Chem. 265 (34): 21039–47. doi: 10.1016/S0021-9258(17)45324-5 . PMID 2250010.

[entrez-5] "Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement)".

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TNP2

Related Research Articles

References

Further reading