SPRY1

Last updated
SPRY1
Identifiers
Aliases SPRY1 , hsprouty RTK signaling antagonist 1
External IDs OMIM: 602465 MGI: 1345139 HomoloGene: 4266 GeneCards: SPRY1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001258038
NM_001258039
NM_005841
NM_199327
NM_001375410

Contents

NM_011896
NM_001305440
NM_001305441
NM_001305442

RefSeq (protein)

NP_001244967
NP_001244968
NP_005832
NP_955359
NP_001362339

NP_001292369
NP_001292370
NP_001292371
NP_036026

Location (UCSC) Chr 4: 123.4 – 123.4 Mb Chr 3: 37.69 – 37.7 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene. [5] [6] [7]


See also

Related Research Articles

FGF3 Protein-coding gene in humans

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

SOS1 Protein-coding gene in the species Homo sapiens

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.

SPRY2

Sprouty homolog 2 (Drosophila), also known as SPRY2, is a protein which in humans is encoded by the SPRY2 gene.

CELSR3

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

CELSR2

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.

FGF10

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.

ASCL1 Protein-coding gene in the species Homo sapiens

Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene. Because it was discovered subsequent to studies on its homolog in Drosophila, the Achaete-scute complex, it was originally named MASH-1 for mammalian achaete scute homolog-1.

GCM1

Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene.

SPRED2

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.

CBLC Protein-coding gene in the species Homo sapiens

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

RhoD

RhoD is a small signaling G protein, and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOD.

ARIH2 Gene of the species Homo sapiens

Protein ariadne-2 homolog is a protein that in humans is encoded by the ARIH2 gene.

ARIH1

Protein ariadne-1 homolog is a protein that in humans is encoded by the ARIH1 gene.

ASCL2 Protein-coding gene in the species Homo sapiens

Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene.

SPRY3 Protein-coding gene in the species Homo sapiens

Protein sprouty homolog 3 is a protein that in humans is encoded by the SPRY3 gene.

CNKSR2 Protein-coding gene in the species Homo sapiens

Connector enhancer of kinase suppressor of ras 2, also known as CNK homolog protein 2 (CNK2) or maguin, is an enzyme that in humans is encoded by the CNKSR2 gene.

SPRY4

Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.

CNIH Protein-coding gene in the species Homo sapiens

Protein cornichon homolog is a protein that in humans is encoded by the CNIH gene.

SPRED1

Sprouty-related, EVH1 domain-containing protein 1 (Spread-1) is a protein that in humans is encoded by the SPRED1 gene located on chromosome 15q13.2 and has seven coding exons.

In molecular biology, the protein Sprouty is a developmental protein involved in cell signalling. It works by inhibiting the MAPK/ERK pathway.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000164056 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037211 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA (January 1998). "sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways". Cell. 92 (2): 253–63. doi: 10.1016/S0092-8674(00)80919-8 . PMID   9458049. S2CID   498977.
  6. Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I (July 2005). "Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation". EMBO Reports. 6 (7): 635–41. doi:10.1038/sj.embor.7400453. PMC   1369112 . PMID   15962011.
  7. "Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)".

Further reading